Academic Journal
Inflammatory factor transport drives macrophage aggregation in an in silico aneurysm inflammation model.
| Τίτλος: | Inflammatory factor transport drives macrophage aggregation in an in silico aneurysm inflammation model. |
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| Συγγραφείς: | Shi ZR; Department of Biomedical Engineering, University of Minnesota Twin Cities , Minneapolis, MN, USA., Wiputra H; Department of Biomedical Engineering, University of Minnesota Twin Cities , Minneapolis, MN, USA., Williams JW; Department of Integrative Biology & Physiology, University of Minnesota Medical School , Minneapolis, MN, USA., Barocas VH; Department of Biomedical Engineering, University of Minnesota Twin Cities , Minneapolis, MN, USA. |
| Πηγή: | Journal of the Royal Society, Interface [J R Soc Interface] 2026 Aug 05; Vol. 23 (241). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Royal Society Country of Publication: England NLM ID: 101217269 Publication Model: Print Cited Medium: Internet ISSN: 1742-5662 (Electronic) Linking ISSN: 17425662 NLM ISO Abbreviation: J R Soc Interface Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : Royal Society, [2004]- |
| Ιατρικοί όροι (MeSH): | Macrophages*/metabolism , Macrophages*/pathology , Inflammation*/metabolism , Inflammation*/pathology , Intracranial Aneurysm*/metabolism , Intracranial Aneurysm*/pathology , Computer Simulation* , Models, Cardiovascular* , Models, Biological*, Humans |
| Περίληψη: | Inflammation plays an important role in the pathological remodelling and rupture of intracranial aneurysms. One of the challenges in predicting the prognosis of intracranial aneurysms lies in the variation of the inflammatory state in aneurysm tissues from patient to patient. The connection between aneurysm biophysical environment and inflammation is largely unexplored by predictive computational models. In this study, a computational model based on a positive feedback mechanism driven by paracrine signalling between monocytes, macrophages and soluble inflammatory factors was proposed. Based on this model, three inflammatory factor transport regimes characterized by the dominance of (i) diffusion, (ii) production, or (iii) removal that drove at distinctive inflammatory dynamics were identified. A dimensionless group, production-to-transport ratio, strongly correlated with the simulated macrophage count (R2=0.97). The theoretical model in this work was simplified, but it demonstrated that inflammatory factor transport could have a profound impact on the inflammation process. This study suggests that haemodynamics may indirectly influence the state of inflammation, beyond the well-documented mechanosensory response of the vascular endothelium, by modulating the transport conditions for inflammatory factors. (© 2026 The Authors.) |
| Grant Information: | R01-NS126762 United States NH NIH HHS; Minnesota Supercomputing Institute |
| Contributed Indexing: | Keywords: atherosclerosis; blood vessel; cerebral artery; chemotaxis; computational; diffusion; intramural; monocyte; plaque; theoretical |
| Entry Date(s): | Date Created: 20260805 Date Completed: 20260805 Latest Revision: 20260805 |
| Update Code: | 20260805 |
| DOI: | 10.1098/rsif.2025.0535 |
| PMID: | 42552991 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1742-5662 |
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| DOI: | 10.1098/rsif.2025.0535 |