Academic Journal
Blood viscosity is associated with smoking status rather than the presence of chronic obstructive pulmonary disease: findings from the Korea COPD Subgroup Study (KOCOSS).
| Τίτλος: | Blood viscosity is associated with smoking status rather than the presence of chronic obstructive pulmonary disease: findings from the Korea COPD Subgroup Study (KOCOSS). |
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| Συγγραφείς: | Lee YJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea., Kang HR; Division of Pulmonary and Allergy, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Republic of Korea., Kim SH; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, Seoul, Republic of Korea., Kim HJ; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Keimyung University Dongsan Hospital, Keimyung University School of Medicine, Daegu, Republic of Korea., Lee JS; Division of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea., Lee CH; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea., Kim SK; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, Republic of Korea., Kim YI; Division of Pulmonology, Department of Internal Medicine, Chonnam National University Hospital, Chonnam National University Medical School, Gwangju, Republic of Korea., Yoo KH; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea., Kim Y; Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea. weilin810707@gmail.com. |
| Πηγή: | Respiratory research [Respir Res] 2026 Aug 04; Vol. 27 (1). Date of Electronic Publication: 2026 Aug 04. |
| Τύπος έκδοσης: | Journal Article; Multicenter Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2001- : London : BioMed Central Ltd. Original Publication: London : Current Science Ltd., c2000- |
| Ιατρικοί όροι (MeSH): | Pulmonary Disease, Chronic Obstructive*/blood , Pulmonary Disease, Chronic Obstructive*/epidemiology , Pulmonary Disease, Chronic Obstructive*/diagnosis , Pulmonary Disease, Chronic Obstructive*/physiopathology , Blood Viscosity*/physiology , Smoking*/blood , Smoking*/epidemiology , Smoking*/adverse effects , Smoking*/physiopathology, Republic of Korea/epidemiology ; Forced Expiratory Volume/physiology ; Humans ; Male ; Female ; Prospective Studies ; Aged ; Middle Aged ; Cohort Studies |
| Περίληψη: | Background: The relationship between smoking and blood viscosity is well established. However, the role of blood viscosity in the development of chronic obstructive pulmonary disease (COPD) and its impact on lung function decline remains unclear. Therefore, we aimed to investigate the association of blood viscosity with COPD and lung function decline, independent of smoking status. Methods: Data from 292 participants in the Korea COPD Subgroup Study (KOCOSS), a multicenter prospective cohort, were analyzed. Subjects were classified into four groups based on smoking history and COPD status. Multiple linear regression analysis was performed to determine the association between baseline viscosity and lung function decline after adjusting for age, sex, smoking status, and COPD status. Results: Of the 292 participants, 93 (31.8%) patients had COPD. Ever smokers with or without COPD were older than never smokers and predominantly male. Never smokers with COPD reported the highest scores for the Modified Medical Research Council Dyspnea Scale. Blood viscosity was significantly higher in ever smokers (with COPD: 9.0 ± 1.4; without COPD 9.2 ± 1.5) than in never smokers (with COPD: 8.7 ± 1.8; without COPD: 8.4 ± 1.5). Viscosity did not differ significantly with the presence of COPD within the same smoking category. Adjusted multiple linear regression revealed that baseline blood viscosity was not associated with 2-year declines in forced expiratory volume in 1 s (p = 0.557), forced vital capacity (p = 0.686), or diffusing capacity of the lung for carbon monoxide (p = 0.947). Conclusion: Blood viscosity appeared to be more closely associated with smoking-related hemorheological changes than with COPD. Its potential as a predictive biomarker for lung function decline appears to be limited, necessitating further long-term investigation. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board of Konkuk University Hospital (IRB number: KUH1010338), which served as the main participating center, and by the Ethics Committee of each participating medical center. All participants provided written informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. |
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| Grant Information: | 06-2023-0016 Seoul National University Bundang Hospital; 2016ER670100, 2016ER670101, 2016ER670102, 2018ER67100, 2018ER67101, 2018ER67102, 2021ER120500, 2021ER120501, 2021ER120502, 2024ER120500, and 2024ER120501). the Korea National Institute of Health-Funded Research Program |
| Contributed Indexing: | Keywords: Blood viscosity; Chronic obstructive pulmonary disease; Lung function decline; Smoking |
| Entry Date(s): | Date Created: 20260805 Date Completed: 20260805 Latest Revision: 20260827 |
| Update Code: | 20260827 |
| PubMed Central ID: | PMC13435482 |
| DOI: | 10.1186/s12931-026-03827-8 |
| PMID: | 42552534 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1465-993X |
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| DOI: | 10.1186/s12931-026-03827-8 |