Academic Journal
Solitary fibrous tumour of the conjunctiva: a rare presentation.
| Τίτλος: | Solitary fibrous tumour of the conjunctiva: a rare presentation. |
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| Συγγραφείς: | Sreekumar SR; Ocular Oncology Service, Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India., Vempuluru VS; Ocular Oncology Service, Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India., Jakati S; Ophthalmic Pathology Department, LV Prasad Eye Institute, Hyderabad, India., Kaliki S; Ocular Oncology Service, Operation Eyesight Universal Institute for Eye Cancer, LV Prasad Eye Institute, Hyderabad, India kalikiswathi@yahoo.com. |
| Πηγή: | BMJ case reports [BMJ Case Rep] 2026 Aug 04; Vol. 19 (8). Date of Electronic Publication: 2026 Aug 04. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: BMJ Pub. Group Country of Publication: England NLM ID: 101526291 Publication Model: Electronic Cited Medium: Internet ISSN: 1757-790X (Electronic) Linking ISSN: 1757790X NLM ISO Abbreviation: BMJ Case Rep Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: London : BMJ Pub. Group |
| Ιατρικοί όροι (MeSH): | Solitary Fibrous Tumors*/radiotherapy , Solitary Fibrous Tumors*/pathology , Solitary Fibrous Tumors*/diagnosis , Solitary Fibrous Tumors*/diagnostic imaging , Conjunctival Neoplasms*/radiotherapy , Conjunctival Neoplasms*/pathology , Conjunctival Neoplasms*/diagnostic imaging , Conjunctival Neoplasms*/diagnosis , Conjunctiva*/pathology , Conjunctiva*/diagnostic imaging, STAT6 Transcription Factor/metabolism ; Brachytherapy/methods ; Humans ; Male ; Middle Aged ; Tomography, Optical Coherence ; Diagnosis, Differential |
| Περίληψη: | A man in his early 50s presented with complaints of a painless, slow-growing mass in his right eye (OD) for 4 months. Examination of OD showed a well-demarcated, firm, subepithelial lesion on the temporal bulbar conjunctiva. Anterior segment optical coherence tomography (AS-OCT) revealed a compact-appearing, mildly reflective subepithelial lesion with back shadowing. Clinical differentials of benign reactive lymphoid hyperplasia and conjunctival lymphoma were considered and an excisional biopsy was performed. Histopathology revealed a cellular stromal tumour comprising spindle cells arranged in short fascicles. The Ki-67 index was 6%. Immunohistochemistry with signal transducer and activator of transcription 6 (STAT-6) showed moderate nuclear expression in lesional cells and giant cells. Correlating the histomorphology and STAT-6 positivity, a final diagnosis of conjunctival solitary fibrous tumour was made. Subsequent Ru-106 plaque radiotherapy was administered at a dose of 50 Gy to the site of the lesion. The patient was doing well with no signs of tumour recurrence at the 18-month follow-up. The novelty of this report lies in the illustration of AS-OCT findings, CD34-negative phenotype and the use of adjuvant Ru-106 plaque brachytherapy. (© BMJ Publishing Group Limited 2026. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Competing Interests: | Competing interests: None declared. |
| Contributed Indexing: | Keywords: Conjunctiva; Oncology; Ophthalmology |
| Substance Nomenclature: | 0 (STAT6 Transcription Factor) |
| Entry Date(s): | Date Created: 20260804 Date Completed: 20260804 Latest Revision: 20260804 |
| Update Code: | 20260810 |
| DOI: | 10.1136/bcr-2025-267268 |
| PMID: | 42552073 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1757-790X |
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| DOI: | 10.1136/bcr-2025-267268 |