Academic Journal
Visual performance of a non-diffractive extended depth of focus IOL in stable early-stage Keratoconus: prospective pilot study.
| Τίτλος: | Visual performance of a non-diffractive extended depth of focus IOL in stable early-stage Keratoconus: prospective pilot study. |
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| Συγγραφείς: | Bonacci E; Ophthalmology Clinic, Department of Engineering for Innovation Medicine, University of Verona, Verona, Italy., Pagnacco C; Ophthalmology Clinic, Department of Surgery, Dentistry, Maternity and Infant, University of Verona, Verona, Italy. camilla.pagnacco@univr.it., Fasolo A; Research Unit, The Veneto Eye Bank Foundation, Venice, Italy., Barzaghi F; Ophthalmology Clinic, Department of Surgery, Dentistry, Maternity and Infant, University of Verona, Verona, Italy., Bonato A; Ophthalmology Clinic, Department of Surgery, Dentistry, Maternity and Infant, University of Verona, Verona, Italy., Idrizi I; Ophthalmology Clinic, Department of Surgery, Dentistry, Maternity and Infant, University of Verona, Verona, Italy., Anastasi M; Ophthalmology Clinic, Department of Surgery, Dentistry, Maternity and Infant, University of Verona, Verona, Italy., Pedrotti E; Ophthalmology Clinic, Department of Surgery, Dentistry, Maternity and Infant, University of Verona, Verona, Italy. |
| Πηγή: | International ophthalmology [Int Ophthalmol] 2026 Aug 04; Vol. 46 (1). Date of Electronic Publication: 2026 Aug 04. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Kluwer Country of Publication: Netherlands NLM ID: 7904294 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-2630 (Electronic) Linking ISSN: 01655701 NLM ISO Abbreviation: Int Ophthalmol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Dordrecht : Kluwer Original Publication: The Hague, Junk. |
| Ιατρικοί όροι (MeSH): | Keratoconus*/physiopathology , Keratoconus*/surgery , Keratoconus*/complications , Visual Acuity*/physiology , Contrast Sensitivity*/physiology , Lens Implantation, Intraocular*/methods , Refraction, Ocular*/physiology , Lenses, Intraocular*, Humans ; Prospective Studies ; Pilot Projects ; Female ; Adult ; Male ; Prosthesis Design ; Follow-Up Studies ; Middle Aged ; Young Adult |
| Περίληψη: | Aims: To evaluate visual performance, contrast sensitivity (CS), optical quality, and subjective satisfaction of Vivity extended depth-of-focus (EDOF) premium intraocular lens (pIOL) in early keratoconus (KC). Methods: In this prospective, interventional, single-center clinical study, ten patients with mild bilateral KC and cataract received AcrySof IQ Vivity pIOL. Pre- and postoperative assessments included monocular and binocular uncorrected and distance-corrected visual acuities at 4 m (UDVA, DCVA), uncorrected and distance-corrected intermediate and near visual acuities at 66 cm (UI66VA, DCI66VA) and 40 cm (UNVA, DCNVA), defocus curve, CS, wavefront aberrometry (RMS, PSF, Strehl ratio), halometry, and subjective outcomes. Results: At 3 months, mean ± SD monocular DCVA in the dominant eyes (primary endpoint) was 0.06 ± 0.13 logMAR. A statistically significant improvement was observed between preoperative and postoperative monocular and binocular UDVA, UNVA, DCNVA (p < 0.001), and DCVA (p = 0.03). Binocular DCI66VA and UI66VA were 0.10 ± 0.15 and 0.14 ± 0.16 logMAR, respectively. The defocus curve was ≤ 0.20 logMAR from + 0.50 D to - 2.00 D. CS peaked under scotopic conditions at 6 cpd, total ocular RMS improved from 2.15 ± 1.98 to 1.09 ± 0.77 (p = 0.09). NEI-RQL-42 scores indicated favourable patient-reported outcomes, particularly for glare, clarity of vision, and satisfaction with correction. Conclusion: In this small prospective pilot study, bilateral implantation of a non-diffractive EDOF IOL was associated with favourable short-term visual outcomes in highly selected patients with stable early keratoconus. These preliminary findings suggest that early stable KC may not represent an absolute contraindication to non-diffractive EDOF IOL implantation, but larger comparative studies with longer follow-up are required. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no conflict of interest. |
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| Grant Information: | IIT#87282333 Alcon |
| Contributed Indexing: | Keywords: Early-stage Keratoconus; Keratoconus; Non-diffractive EDOF IOL; Premium IOL; Visual outcomes |
| Entry Date(s): | Date Created: 20260804 Date Completed: 20260804 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13437671 |
| DOI: | 10.1007/s10792-026-04186-5 |
| PMID: | 42550346 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1573-2630 |
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| DOI: | 10.1007/s10792-026-04186-5 |