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The Ion Permeability of DNA Nanotube Channels.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The Ion Permeability of DNA Nanotube Channels.
Συγγραφείς: Dhanasekar NN; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Li Y; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA., Schulman R; Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Computer Science, Johns Hopkins University, Baltimore, Maryland, USA.; Department of Chemistry, Johns Hopkins University, Baltimore, Maryland, USA.
Πηγή: Small (Weinheim an der Bergstrasse, Germany) [Small] 2026 Sep; Vol. 22 (51), pp. e74625. Date of Electronic Publication: 2026 Aug 03.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101235338 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1613-6829 (Electronic) Linking ISSN: 16136810 NLM ISO Abbreviation: Small Subsets: MEDLINE
Imprint Name(s): Original Publication: Weinheim, Germany : Wiley-VCH, c2005-
Ιατρικοί όροι (MeSH): Nanotubes*/chemistry , DNA*/chemistry , Ions*/chemistry, Nanotechnology/methods ; DNA Nanostructures ; Permeability
Περίληψη: Techniques from structural DNA nanotechnology make it possible to assemble complex 3-dimensional nanostructures with virtually arbitrary control over their sizes, shapes, and features at length scales of 3-100 nm, providing a flexible means for constructing nanoscale devices and machines. Here, we assemble micrometer-long DNA nanotubes and assess their performance as pipes for controlled ion transport. DNA nanotubes grow via assembly of DNA tiles from a seed pore, a 12-helix DNA origami cylinder functionalized with 18 cholesterol anchors, to generate a DNA nanotube channel. The central channel of a nanotube can be obstructed via Watson-Crick hybridization of a channel cap, a second DNA origami structure, clamped to its end. The single-channel electrical recordings show that both nanotube seed pores and nanotube channels display ohmic ion conductance consistent with their central channels' diameters. Binding of the channel cap reduces the conductances of both DNA nanotube channels and seed pores, indicating that ion transport can be modulated and measuring the resulting residual transport through DNA-wall gaps or DNA-lipid interfacial pathways. Our findings help design self-assembling nanofluidic devices and circuits in which transport may be regulated via dynamic biomolecular interactions, since these channels could be constructed into branched topologies or routed between specific molecular terminals.
(© 2026 Wiley‐VCH GmbH.)
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Grant Information: D16AP00147 DARPA
Contributed Indexing: Keywords: DNA nanopores; DNA nanotubes; channel cap; droplet‐interface bilayer; single‐channel conductance
Substance Nomenclature: 9007-49-2 (DNA)
0 (Ions)
Entry Date(s): Date Created: 20260803 Date Completed: 20260911 Latest Revision: 20260913
Update Code: 20260913
PubMed Central ID: PMC13569080
DOI: 10.1002/smll.74625
PMID: 42544780
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1613-6829
DOI:10.1002/smll.74625