Academic Journal
Myco-assisted zinc oxide nanoparticles by Aspergillus sp. SA18: Chemical profiling, antimicrobial, anticancer, and computational insights into GyrA and GyrB inhibition with ADME physicochemical properties.
| Τίτλος: | Myco-assisted zinc oxide nanoparticles by Aspergillus sp. SA18: Chemical profiling, antimicrobial, anticancer, and computational insights into GyrA and GyrB inhibition with ADME physicochemical properties. |
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| Συγγραφείς: | El Hawary S; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Giza, Egypt., El-Sayyad GS; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia. Electronic address: gelsayyd@imamu.edu.sa., El Raey MA; Department of Phytochemistry and Plant Systematics, Pharmaceutical Division, National Research Centre, 33 El Bohouth Street, P.O. Box 12622, Dokki, Cairo, 12622, Egypt., Abdelrahman SESAH; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Giza, Egypt., Mohsen E; Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Giza, Egypt., Bendif H; Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, 11623, Saudi Arabia., Hamed AA; Microbial Chemistry Department, National Research Centre, 33 El-Buhouth Street, Dokki, Giza, 12622, Egypt., Ghareeb MA; Medicinal Chemistry Department, Theodor Bilharz Research Institute, Kornish El-Nile, Warrak El-Hadar, Imbaba, Giza, 12411, Egypt. Electronic address: m.ghareeb@tbri.gov.eg. |
| Πηγή: | Archives of biochemistry and biophysics [Arch Biochem Biophys] 2026 Nov; Vol. 785, pp. 110952. Date of Electronic Publication: 2026 Aug 01. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2000- > : San Diego, CA : Elsevier Original Publication: New York, NY : Academic Press |
| Ιατρικοί όροι (MeSH): | Aspergillus*/chemistry , Aspergillus*/metabolism , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/metabolism , Zinc Oxide*/chemistry , Zinc Oxide*/pharmacology , Zinc Oxide*/metabolism , DNA Gyrase*/metabolism , DNA Gyrase*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Anti-Infective Agents*/metabolism , Metal Nanoparticles*/chemistry, Candida albicans/drug effects ; Pseudomonas aeruginosa/drug effects ; Nanoparticles/chemistry ; Humans ; MCF-7 Cells ; Molecular Docking Simulation ; Hep G2 Cells |
| Περίληψη: | This study aimed to biosynthesize zinc oxide nanoparticles (ZnONPs) using a marine-derived Aspergillus sp. SA18 fungal extract and assess their antimicrobial and anticancer properties. ZnONPs were characterized by UV-Vis. spectroscopy, FTIR, XRD, TEM, SEM, and zeta potential analyses. Characterization approved successful nanoparticle synthesis, with a crystalline structure and an average particle size of 75 nm based on XRD analysis, while TEM and SEM exposed polydisperse spherical particles ranging from 80 to 96 nm. The synthesized ZnONPs showed a zeta potential of -21.03 mV, demonstrating good colloidal stability. Antimicrobial test demonstrated prominent activity, with the fungal extract displaying the highest inhibition zones against Pseudomonas aeruginosa and Candida albicans (16 mm each). Cytotoxicity assessment disclosed strong anticancer activity of the fungal extract against MCF-7 and HepG2 cell lines, with IC (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Competing interests No conflict of interests. |
| Contributed Indexing: | Keywords: Antimicrobial; Aspergillus sp. SA18; DNA gyrase-ADME-Toxicity prediction; Good health and well-being; ZnONPs |
| Substance Nomenclature: | 0 (Antineoplastic Agents) SOI2LOH54Z (Zinc Oxide) EC 5.99.1.3 (DNA Gyrase) 0 (Anti-Infective Agents) |
| Entry Date(s): | Date Created: 20260801 Date Completed: 20260905 Latest Revision: 20260905 |
| Update Code: | 20260906 |
| DOI: | 10.1016/j.abb.2026.110952 |
| PMID: | 42542237 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1096-0384 |
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| DOI: | 10.1016/j.abb.2026.110952 |