Academic Journal
A facile synthesis, biological evaluation, ADMET profiling and computational insights of novel triazole-linked tetrahydrobenzo[b]thiophenes: A sonochemical click synthetic strategy in recyclable ionic liquid medium.
| Τίτλος: | A facile synthesis, biological evaluation, ADMET profiling and computational insights of novel triazole-linked tetrahydrobenzo[b]thiophenes: A sonochemical click synthetic strategy in recyclable ionic liquid medium. |
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| Συγγραφείς: | Kurahatti S; Department of Chemistry, Karnatak University's Karnatak Science College, Dharwad, Karnataka 580001, India., Kalkhambkar RG; Department of Chemistry, Karnatak University's Karnatak Science College, Dharwad, Karnataka 580001, India. Electronic address: rgkalkhambkar2020@gmail.com., Dalbanjan NP; Dr. Prabhakar Kore Basic Science Research Centre, KLE Academy of Higher Education and Research (Deemed to be University), Nehru Nagar, Belagavi, Karnataka 590010, India. |
| Πηγή: | Bioorganic chemistry [Bioorg Chem] 2026 Oct 05; Vol. 181, pp. 110286. Date of Electronic Publication: 2026 Jul 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| Ιατρικοί όροι (MeSH): | Ionic Liquids*/chemistry , Triazoles*/chemistry , Triazoles*/pharmacology , Thiophenes*/pharmacology , Thiophenes*/chemistry , Thiophenes*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemical synthesis , Anti-Bacterial Agents*/chemistry , Antifungal Agents*/pharmacology , Antifungal Agents*/chemical synthesis , Antifungal Agents*/chemistry , Antioxidants*/pharmacology , Antioxidants*/chemical synthesis , Antioxidants*/chemistry, Staphylococcus aureus/drug effects ; Candida albicans/drug effects ; Escherichia coli/drug effects ; Candida glabrata/drug effects ; Biphenyl Compounds/antagonists & inhibitors ; Microbial Sensitivity Tests ; Molecular Structure ; Click Chemistry ; Structure-Activity Relationship ; Molecular Docking Simulation ; Dose-Response Relationship, Drug |
| Περίληψη: | A series of novel 1,2,3-triazole-linked tetrahydrobenzo[b]thiophene derivatives were synthesized through a Green and sustainable sonochemical protocol by employing copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) in a recyclable [BMIM][BF (Copyright © 2026 Elsevier Inc. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Click chemistry; Green chemistry; Ionic liquids; Sonochemistry; Thiophenes; Triazoles; Ultrasonication |
| Substance Nomenclature: | 0 (Ionic Liquids) 0 (Triazoles) 0 (Thiophenes) 0 (Anti-Bacterial Agents) 0 (Antifungal Agents) 0 (Antioxidants) 0 (Biphenyl Compounds) |
| Entry Date(s): | Date Created: 20260801 Date Completed: 20260909 Latest Revision: 20260909 |
| Update Code: | 20260909 |
| DOI: | 10.1016/j.bioorg.2026.110286 |
| PMID: | 42542009 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2026.110286 |