Academic Journal
From psoriatic plaque to synovium: decoding the skin-joint axis in psoriatic arthritis.
| Τίτλος: | From psoriatic plaque to synovium: decoding the skin-joint axis in psoriatic arthritis. |
|---|---|
| Συγγραφείς: | Raimondo MG; Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany., Gandolfo S; Department of Precision Medicine, Rheumatology Section, University of Campania L. Vanvitelli, Naples, Italy.; Rheumatology Unit, Ospedale del Mare, Naples, Italy., Gensler LS; Department of Medicine/Rheumatology, University of California, San Francisco, CA, USA., Thomas R; Frazer Institute, The University of Queensland, Brisbane, Queensland, Australia., Schett G; Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany., Ramming A; Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany. andreas.ramming@uk-erlangen.de.; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany. andreas.ramming@uk-erlangen.de., Ciccia F; Department of Precision Medicine, Rheumatology Section, University of Campania L. Vanvitelli, Naples, Italy. francesco.ciccia@unicampania.it. |
| Πηγή: | Nature reviews. Rheumatology [Nat Rev Rheumatol] 2026 Oct; Vol. 22 (10), pp. 615-625. Date of Electronic Publication: 2026 Jul 31. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101500080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1759-4804 (Electronic) Linking ISSN: 17594790 NLM ISO Abbreviation: Nat Rev Rheumatol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: New York, NY : Nature Pub. Group |
| Ιατρικοί όροι (MeSH): | Arthritis, Psoriatic*/immunology , Arthritis, Psoriatic*/pathology , Synovial Membrane*/pathology , Synovial Membrane*/immunology , Skin*/pathology , Skin*/immunology , Joints*/pathology , Joints*/immunology, T-Lymphocytes/immunology ; Humans |
| Περίληψη: | Psoriatic arthritis (PsA) develops in up to 30% of individuals with psoriasis, but the mechanisms that drive progression from skin-limited disease to musculoskeletal disease remain incompletely understood. Emerging evidence supports a functional skin-joint axis in which psoriatic plaques function not only as sites of local inflammation but also as sources of immune cells capable of shaping musculoskeletal pathology. Myeloid progenitors that reside in the inflamed skin can migrate to synovial compartments; however, cell trafficking alone is insufficient to induce arthritis, as the fate of these cells is dictated by the stromal microenvironment of the musculoskeletal niche. Data from single-cell RNA sequencing, imaging mass cytometry and mitochondrial DNA lineage tracing now provide direct evidence that skin-derived myeloid precursors populate synovial tissue in people with early PsA. In parallel, T cell receptor analyses indicate that clonally related T cells are shared between psoriatic skin and inflamed joints, indicating that skin-derived T cells migrate between tissues. Together, these findings fuel a model in which PsA emerges through the convergence of high-risk skin lesions, a systemic milieu permissive to immune cell trafficking and a receptive joint stromal niche, with implications for biomarker discovery, risk stratification and disease interception. (© 2026. Springer Nature Limited.) |
| Competing Interests: | Competing interests: The authors declare no competing interests. |
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| Entry Date(s): | Date Created: 20260731 Date Completed: 20260922 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1038/s41584-026-01412-3 |
| PMID: | 42538408 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1759-4804 |
|---|---|
| DOI: | 10.1038/s41584-026-01412-3 |