Academic Journal
Synthesis and characterization of menthol- and thymol-loaded nanoliposomes with potent antibacterial, antifungal, antioxidant, and anticancer properties.
| Τίτλος: | Synthesis and characterization of menthol- and thymol-loaded nanoliposomes with potent antibacterial, antifungal, antioxidant, and anticancer properties. |
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| Συγγραφείς: | Davoudi Y; Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 81746-73441, Iran., Aryanmanesh A; Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 81746-73441, Iran., Fazayel-Hosseini SE; Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 81746-73441, Iran., Kajani AA; Department of Biotechnology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan 81746-73441, Iran. Electronic address: agh.abbasi@bio.ui.ac.ir. |
| Πηγή: | Food chemistry [Food Chem] 2026 Oct 01; Vol. 525 (Pt 3), pp. 150568. Date of Electronic Publication: 2026 Jul 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Barking : Elsevier Applied Science Publishers Original Publication: Barking, Eng., Applied Science Publishers. |
| Ιατρικοί όροι (MeSH): | Thymol*/chemistry , Thymol*/pharmacology , Thymol*/chemical synthesis , Antioxidants*/pharmacology , Antioxidants*/chemistry , Antioxidants*/chemical synthesis , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/chemical synthesis , Menthol*/chemistry , Menthol*/pharmacology , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry , Antineoplastic Agents*/chemical synthesis , Antifungal Agents*/pharmacology , Antifungal Agents*/chemistry , Antifungal Agents*/chemical synthesis, Liposomes/chemistry ; Liposomes/pharmacology ; Nanoparticles/chemistry ; Humans ; Microbial Sensitivity Tests |
| Περίληψη: | High colloidal and monodispersed nanoliposomes (NLPs) loaded with menthol (M-NLPs), thymol (T-NLPs) and their combination (MT-NLPs) were synthesized by the simple and efficient method of ethanol injection. HPLC studies clarified maximum loading concentrations of 13.7 and 11.3 mg mL-1 followed by zero-order kinetic model of 60.5% release and first-order kinetic model of 64.6% release of menthol and thymol, respectively. MTT assay revealed high biocompatibility of all NLPs and their significant anticancer activity, in vitro. ABTS and DPPH assays showed high antioxidant activity of 93.2% for M-NLPs after 5 months. The sustained and prominent antibacterial activity with MIC value of 0.312 mg mL-1 obtained against E. coli and S. aureus using M-NLPs, T-NLPs, and MT-NLPs. Complete growth inhibition of A. niger, A. flavus, and A. terreus obtained at 0.25 mg mL-1 of MT-NLPs. Overall results indicated high potential of the liposomal formulations for food and agricultural applications, especially as food additive. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Antibacterial; Anticancer; Antifungal; Antioxidant; Food additive; Liposomes; Menthol; Thymol |
| Substance Nomenclature: | 3J50XA376E (Thymol) 0 (Antioxidants) 0 (Liposomes) 0 (Anti-Bacterial Agents) 1490-04-6 (Menthol) 0 (Antineoplastic Agents) 0 (Antifungal Agents) |
| Entry Date(s): | Date Created: 20260731 Date Completed: 20260906 Latest Revision: 20260906 |
| Update Code: | 20260906 |
| DOI: | 10.1016/j.foodchem.2026.150568 |
| PMID: | 42537538 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-7072 |
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| DOI: | 10.1016/j.foodchem.2026.150568 |