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Antibacterial Properties of Origanum vulgare and Eucalyptus staigeriana Essential Oils Single or in Combination With Cloxacillin Against Corynebacterium pseudotuberculosis.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Antibacterial Properties of Origanum vulgare and Eucalyptus staigeriana Essential Oils Single or in Combination With Cloxacillin Against Corynebacterium pseudotuberculosis.
Συγγραφείς: de Aguiar Policarpo W; Ceará State University, Post-Graduate Program in Veterinary Sciences (PPGCV), Fortaleza, Ceará, Brazil.; Center For Bioprospecting and Applied Molecular Experimentation (NUBEM), Center on Health Science at INTA University Center - UNINTA, Sobral, Brazil., de Carvalho FJN; Center For Bioprospecting and Applied Molecular Experimentation (NUBEM), Center on Health Science at INTA University Center - UNINTA, Sobral, Brazil., da Silva BF; Center For Bioprospecting and Applied Molecular Experimentation (NUBEM), Center on Health Science at INTA University Center - UNINTA, Sobral, Brazil.; Northeast Network of Biotechnology Program (RENORBIO), State University of Ceará, Fortaleza, Brazil., da Silva WMB; Chemistry Program, State University Vale Do Acaraú, Sobral Campus. Graduate Program in Biotechnology, Federal University of Ceará, Sobral, Brazil., Carneiro VA; Center For Bioprospecting and Applied Molecular Experimentation (NUBEM), Center on Health Science at INTA University Center - UNINTA, Sobral, Brazil.; Laboratory of Biofilms and Antimicrobial Agents (LaBAM), Faculty of Medicine at INTA University Center - UNINTA, Fortaleza, Brazil., Costa RA; Center For Bioprospecting and Applied Molecular Experimentation (NUBEM), Center on Health Science at INTA University Center - UNINTA, Sobral, Brazil., Faccioli-Martins PY; Brazilian Agricultural Research Corporation - Embrapa Goats and Sheep, Km 4 Rodovia Moésio Loiola De Melo Júnior, Sobral, Ceará, Brazil., de Morais SM; Ceará State University, Post-Graduate Program in Veterinary Sciences (PPGCV), Fortaleza, Ceará, Brazil.
Πηγή: Chemistry & biodiversity [Chem Biodivers] 2026 Aug; Vol. 23 (8), pp. e71523.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
Imprint Name(s): Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-
Ιατρικοί όροι (MeSH): Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/chemistry , Anti-Bacterial Agents*/isolation & purification , Origanum*/chemistry , Oils, Volatile*/pharmacology , Oils, Volatile*/chemistry , Oils, Volatile*/isolation & purification , Cloxacillin*/pharmacology , Cloxacillin*/chemistry , Eucalyptus*/chemistry , Corynebacterium pseudotuberculosis*/drug effects, Antioxidants/pharmacology ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Microbial Sensitivity Tests
Περίληψη: Caseous lymphadenitis is a chronic infectious disease caused by Corynebacterium pseudotuberculosis that affects small ruminants, resulting in significant economic losses. In response, essential oils (EO) have emerged as promising natural alternatives for disease control. The present study evaluated the chemical composition, antioxidant capacity, and antibacterial activity of EO from Origanum vulgare (OVEO) and Eucalyptus staigeriana (ESEO) against C. pseudotuberculosis isolated from Northeastern Brazil. The antibacterial effect was assessed by disk diffusion, minimum inhibitory concentration (MIC), Minimum Bactericidal Concentration, time-kill assays, and combination tests with cloxacillin. Gas chromatography analysis identified carvacrol as the major compound in OVEO, and D-limonene in ESEO. OVEO demonstrated strong antibacterial efficacy, exhibiting inhibition zones of up to 74 mm and MICs ranging from 31.2 to 250 µg/mL. Both EOs demonstrated bactericidal properties and exhibited additive interactions with cloxacillin (FICi 0.56-1.03). Furthermore, OVEO exhibited strong antioxidant activity (IC50 = 6.89 ± 0.58 µg/mL). These findings underscore the significance of bioactive compounds with antibacterial potential, although further studies are necessary to evaluate their applicability for managing caseous lymphadenitis.
(© 2026 Wiley‐VHCA AG.)
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Grant Information: 001 Coordination for the Improvement of Higher Education Personnel (CAPES); 20.20.03.002.00.00 Brazilian Agricultural Research Corporation (EMBRAPA); BP6-0241-00292.01.00/25 Cearense Foundation for Scientific and Technological Development (FUNCAP); 312597/2023-1 National Council for Scientific and Technological Development (CNPq)
Contributed Indexing: Keywords: Caseous lymphadenitis; antimicrobial activity; antioxidants; biological activity; essential oils
Substance Nomenclature: 0 (Anti-Bacterial Agents)
0 (Oils, Volatile)
O6X5QGC2VB (Cloxacillin)
0 (Antioxidants)
Entry Date(s): Date Created: 20260731 Date Completed: 20260731 Latest Revision: 20260802
Update Code: 20260802
PubMed Central ID: PMC13424972
DOI: 10.1002/cbdv.71523
PMID: 42533565
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1612-1880
DOI:10.1002/cbdv.71523