Novel Proactive Speech-Language Intervention Is More Effective Than Usual Care: Randomized Controlled Trial of Babble Boot Camp for Infants With Classic Galactosemia.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Novel Proactive Speech-Language Intervention Is More Effective Than Usual Care: Randomized Controlled Trial of Babble Boot Camp for Infants With Classic Galactosemia.
Συγγραφείς:	Potter N; Department of Speech and Hearing Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane., Choi M; College of Health Solutions, Arizona State University, Phoenix., Schrock C; Department of Speech and Hearing Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane., Heinlen V; Department of Speech and Hearing Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane., Bruce L; College of Health Solutions, Arizona State University, Phoenix., Davis J; College of Health Solutions, Arizona State University, Phoenix., Scherer N; College of Health Solutions, Arizona State University, Phoenix., Eng L; College of Health Solutions, Arizona State University, Phoenix., Finestack L; Department of Speech-Language-Hearing Sciences, University of Minnesota, Minneapolis., Stoel-Gammon C; Department of Speech & Hearing Sciences, University of Washington, Seattle., VanDam M; Department of Speech and Hearing Sciences, Elson S. Floyd College of Medicine, Washington State University, Spokane., Raaz C; Department of Communication Sciences and Disorders, University of Northern Colorado, Greeley., Armstrong-Heimsoth A; Department of Occupational Therapy, Northern Arizona University, Phoenix., Kim Y; College of Health Solutions, Arizona State University, Phoenix., Peter B; College of Health Solutions, Arizona State University, Phoenix.
Πηγή:	Journal of speech, language, and hearing research : JSLHR [J Speech Lang Hear Res] 2026 Sep 10; Vol. 69 (9), pp. 4405-4426. Date of Electronic Publication: 2026 Jul 30.
Τύπος έκδοσης:	Journal Article; Randomized Controlled Trial
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: American Speech-Language-Hearing Association Country of Publication: United States NLM ID: 9705610 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1558-9102 (Electronic) Linking ISSN: 10924388 NLM ISO Abbreviation: J Speech Lang Hear Res Subsets: MEDLINE
Imprint Name(s):	Original Publication: Rockville, MD : American Speech-Language-Hearing Association, c1997-
Ιατρικοί όροι (MeSH):	Galactosemias/complications , Galactosemias/therapy , Speech Therapy/methods , Speech Disorders/prevention & control , Speech Disorders/etiology , Speech Disorders/therapy , Language Therapy/methods , Language Development Disorders/etiology , Language Development Disorders/prevention & control , Language Development Disorders/therapy, Humans ; Infant ; Male ; Female ; Child, Preschool ; Treatment Outcome
Περίληψη:	Purpose: Speech and language disorders cannot be diagnosed and treated until children are approximately 2-4 years old. To investigate whether these disorders can be prevented, we developed and trialed Babble Boot Camp (BBC), the first proactive sustained intervention starting with precursor skills including cooing and babbling. Method: Participants were two randomly assigned groups of 22 infants with classic galactosemia, a metabolic disease with known risks for severe speech and language disorders. One group started BBC at under 6 months of age, and the other started at 15 months of age, both completing BBC at 24 months of age. Coached by a speech-language pathologist in weekly telehealth sessions, caregivers implemented BBC activities and routines daily at home. A typical control group and a group of children with classic galactosemia who received usual care participated as well. All children completed standardized assessments of speech and language at postintervention. Results: Assessment scores showed that BBC was more effective than usual care for both intervention groups. Greatest benefits were seen in the group that started at or before 6 months of age, with a proportion of clinically concerning scores equal to that in the typically developing peers. No effects of sex, genotype, or milk consumption were evident in the outcomes. Conclusions: Findings motivate a paradigm shift from deficit-based to proactive approaches for infants with classic galactosemia. BBC is extensible to many other disorders, with trials currently underway for infants with Down syndrome and infants born preterm.
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Grant Information:	P30 DC004662 United States DC NIDCD NIH HHS; R01 HD098253 United States HD NICHD NIH HHS
Entry Date(s):	Date Created: 20260730 Date Completed: 20260910 Latest Revision: 20260922
Update Code:	20260923
PubMed Central ID:	PMC13577952
DOI:	10.1044/2026_JSLHR-25-00579
PMID:	42531571
Βάση Δεδομένων:	MEDLINE

Περιγραφή
ISSN:	1558-9102
DOI:	10.1044/2026_JSLHR-25-00579