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A review of animal models of vascular dementia.

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Title: A review of animal models of vascular dementia.
Authors: Song Y; Heilongjiang University of Chinese Medicine, Harbin, 150006, China., Chen Y; Department of Acupuncture Fifth, The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 26, Heping Road, Xiangfang District, Harbin, 150006, Heilongjiang, China. chyh9000@163.com.
Source: Molecular biology reports [Mol Biol Rep] 2026 Jul 30; Vol. 53 (1). Date of Electronic Publication: 2026 Jul 30.
Publication Type: Journal Article; Review
Language: English
Journal Info: Publisher: Reidel Country of Publication: Netherlands NLM ID: 0403234 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-4978 (Electronic) Linking ISSN: 03014851 NLM ISO Abbreviation: Mol Biol Rep Subsets: MEDLINE
Imprint Name(s): Original Publication: Dordrecht, Boston, Reidel.
MeSH Terms: Dementia, Vascular*/pathology , Dementia, Vascular*/physiopathology , Dementia, Vascular*/metabolism , Dementia, Vascular*/etiology , Disease Models, Animal*, Brain/pathology ; Animals ; Humans
Abstract: Vascular dementia (VD) is characterized by the presence of cerebrovascular lesions, specifically hemorrhagic or ischemic lesions within the brain parenchyma, with ischemic lesions being more prevalent. The resultant progressive decline in cognitive abilities and memory poses a significant challenge to public health and quality of life. Consequently, a growing number of researchers have focused on exploring the pathogenesis, prevention, and treatment strategies for VD. The establishment of suitable animal models for investigating the underlying mechanisms of VD treatment and assessing therapeutic efficacy has emerged as a focal point in this area of research. This review systematically compares the construction methods, pathological features, and behavioral phenotypes of classical and modified VD animal models, while analyzing their respective advantages and limitations. Key obstacles to clinical translation presented by the existing models are highlighted, including species differences, behavioral confounding factors, and issues related to methodological reproducibility. Furthermore, this article offers a reference framework for model selection based on various research objectives, aimed at enhancing the translational value of preclinical VD investigations.
(© 2026. The Author(s), under exclusive licence to Springer Nature B.V.)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable.
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Contributed Indexing: Keywords: Animal model; Research review; Vascular dementia
Entry Date(s): Date Created: 20260730 Date Completed: 20260730 Latest Revision: 20261010
Update Code: 20261010
DOI: 10.1007/s11033-026-12401-w
PMID: 42530688
Database: MEDLINE
Description
ISSN:1573-4978
DOI:10.1007/s11033-026-12401-w