Academic Journal
Medium-sized follicle proportion on the trigger day may be associated with higher live birth rate in fresh embryo transfer cycles among low-prognosis patients: a retrospective cohort study.
| Τίτλος: | Medium-sized follicle proportion on the trigger day may be associated with higher live birth rate in fresh embryo transfer cycles among low-prognosis patients: a retrospective cohort study. |
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| Συγγραφείς: | Yin H; Reproductive Medicine Center, Anhui No.2 Provincial People's Hospital, Hefei, China.; Anhui Institute of Medicine, Hefei, China., Zhu J; Reproductive Medicine Center, The 901st Hospital of PLA Joint Logistics Support Force, Hefei, China., Wang C; Reproductive Medicine Center, The 901st Hospital of PLA Joint Logistics Support Force, Hefei, China., Luan K; Reproductive Medicine Center, The 901st Hospital of PLA Joint Logistics Support Force, Hefei, China., Wu Y; Reproductive Medicine Center, The 901st Hospital of PLA Joint Logistics Support Force, Hefei, China., Ni F; Reproductive Medicine Center, The 901st Hospital of PLA Joint Logistics Support Force, Hefei, China. |
| Πηγή: | Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2026 Jul 15; Vol. 17, pp. 1888870. Date of Electronic Publication: 2026 Jul 15 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101555782 Publication Model: eCollection Cited Medium: Print ISSN: 1664-2392 (Print) Linking ISSN: 16642392 NLM ISO Abbreviation: Front Endocrinol (Lausanne) Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Lausanne : Frontiers Research Foundation] |
| Ιατρικοί όροι (MeSH): | Embryo Transfer*/methods , Live Birth*/epidemiology , Ovulation Induction*/methods , Ovarian Follicle* , Birth Rate*, Gonadotropin-Releasing Hormone/antagonists & inhibitors ; Oocyte Retrieval/methods ; Fertilization in Vitro/methods ; Humans ; Female ; Retrospective Studies ; Pregnancy ; Prognosis ; Adult ; Pregnancy Rate ; Pregnancy Outcome |
| Περίληψη: | Objective: To investigate the association of medium-size follicle proportions (MFP) on the trigger day with the pregnancy outcomes in low prognosis patients undergoing GnRH antagonist protocol. Materials and Methods: A total of 1084 oocyte-retrieval cycles from 765 patients diagnosed with low prognosis according to POSEIDON criteria were enrolled in this retrospective study between January 2017 and December 2023. MFP was defined as ratio of the number of follicles sized 13-18 mm to the number of follicles ≥ 12 mm on trigger day. According to the value of MFP, cycles were divided into MFP < 70% and MFP ≥ 70% groups. Cycle characteristics, laboratory data and pregnancy outcomes were compared between the two groups. Multivariate logistic regression analysis was used to identify whether the value of MFP was independent predictor of live birth. Results: The live birth rate (LBR) (20.75% vs 31.88%, P = 0.003) in fresh embryo transfer cycles was significantly lower in the MFP < 70% group than in the MFP ≥ 70% group. This difference was observed both in patients aged ≤ 35 years (28.18% vs 43.28%, P = 0.0148) and > 35 years (14.50% vs 23.66%, P = 0.0444). A significant increase in GnRH-antagonist dose (0.91 ± 0.44 mg vs 0.78 ± 0.43 mg, P < 0.0001) and duration (3.61 ± 1.57 days vs 3.11 ± 1.55 days, P < 0.0001) was observed in MFP < 70% group. No significant difference was observed in the LBR between groups in frozen-thawed embryo transfer (FET) cycles. Multivariate logistic regression analysis showed that the value of MFP was positively associated with live births in fresh transfers whether MFP was modeled as a continuous variable (per 1% increase) or as a binary threshold (≥ 70% vs. < 70%). Conclusions: These findings highlight the significant association of MFP with LBR in fresh transfer cycles, suggesting that more attention should be paid to medium-sized follicle development when determining the timing of trigger and embryo transfer strategies for low prognosis patients. No significant association was observed in FET cycles, suggesting that the benefit of higher MFP may be specific to fresh transfer. (Copyright © 2026 Yin, Zhu, Wang, Luan, Wu and Ni.) |
| Competing Interests: | The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. |
| Contributed Indexing: | Keywords: GnRH antagonist protocol; POSEIDON criteria; follicle size; live birth rate; low prognosis |
| Substance Nomenclature: | 33515-09-2 (Gonadotropin-Releasing Hormone) |
| Entry Date(s): | Date Created: 20260730 Date Completed: 20260730 Latest Revision: 20260730 |
| Update Code: | 20260730 |
| PubMed Central ID: | PMC13417633 |
| DOI: | 10.3389/fendo.2026.1888870 |
| PMID: | 42529482 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1664-2392 |
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| DOI: | 10.3389/fendo.2026.1888870 |