Academic Journal
Accuracy of multimodal intravascular imaging in evaluating neointimal tissue in a swine femoropopliteal artery stent model.
| Τίτλος: | Accuracy of multimodal intravascular imaging in evaluating neointimal tissue in a swine femoropopliteal artery stent model. |
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| Συγγραφείς: | Aihara K; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan., Torii S; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan. shoz3333@gmail.com., Nakamura N; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan., Shiozaki M; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan., Sato Y; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan., Kato T; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan., Matsumoto Y; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan., Ikari Y; Department of Cardiology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Kanagawa, Japan., Nakazawa G; Department of Cardiology, Kindai University Faculty of Medicine, Sakai, Japan. |
| Πηγή: | Cardiovascular intervention and therapeutics [Cardiovasc Interv Ther] 2026 Oct; Vol. 41 (4), pp. 1077-1086. Date of Electronic Publication: 2026 Jul 29. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Country of Publication: Japan NLM ID: 101522043 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1868-4297 (Electronic) Linking ISSN: 18684297 NLM ISO Abbreviation: Cardiovasc Interv Ther Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Tokyo : Springer |
| Ιατρικοί όροι (MeSH): | Popliteal Artery*/diagnostic imaging , Popliteal Artery*/surgery , Popliteal Artery*/pathology , Femoral Artery*/diagnostic imaging , Femoral Artery*/pathology , Femoral Artery*/surgery , Neointima*/diagnostic imaging , Neointima*/pathology , Ultrasonography, Interventional*/methods , Stents*/adverse effects , Multimodal Imaging*/methods, Angioscopy/methods ; Animals ; Swine ; Disease Models, Animal |
| Περίληψη: | Stent failure, including in-stent restenosis (ISR) and occlusion, remains a major challenge in femoropopliteal arteries. Since the underlying cause of stent failure, such as fibrin-rich thrombus versus organized fibrous plaque, likely dictates the optimal treatment strategy, accurate characterization of neointimal tissue is crucial. However, pathological validation for key intravascular imaging modalities in this setting is lacking. A total of 22 femoral arteries with an in-stent restenosis model in healthy swine after stent implantation were evaluated. One month later, intravascular imaging using intravascular ultrasound (IVUS), optical frequency domain imaging (OFDI), and angioscopy was performed. Diagnostic accuracy for characterizing neointimal tissue ≥ 1000 μm (thick neointima) was assessed using histology as the gold standard. For detecting fibrin/organizing thrombus, IVUS showed high specificity (96%) but poor sensitivity (13%), leading to underestimation. Conversely, OFDI offered relatively high sensitivity (60%) but a modest positive predictive value (PPV, 50%), risking overestimation. A paired use of IVUS and OFDI approach overcame these limitations, yielding significantly improved diagnostic accuracy (sensitivity 50%, specificity 96%, PPV 83%). While angioscopy showed excellent specificity (100%), its utility was limited by very low sensitivity (24%). Paired use of IVUS and OFDI may improve diagnostic confidence for neointimal tissue characterization. In contrast, the utility of angioscopy appears limited due to low sensitivity. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflicting Interests: Sho Torii received research grants from Abbot Vascular Japan, Boston Scientific Japan, and Medtronic, and received honoraria from Boston Scientific Japan. Gaku Nakazawa is a consultant for Boston Scientific, Abbott Vascular, Terumo Corp., and Japan Medical Device Technology Co., Ltd, and received research grants from Boston Scientific, Abbott Vascular, Terumo Corp., and Japan Medical Device Technology Co., Ltd. The remaining authors have nothing to disclose. IRB Information: The Japanese Association for Laboratory Animal Science (Reference no. IVT22-90, S23-058). |
| References: | Circulation. 2024 Jun 11;149(24):e1313-e1410. (PMID: 38743805) Cardiovasc Interv Ther. 2025 Apr;40(2):226-233. (PMID: 39873844) Eur J Vasc Endovasc Surg. 2021 Jan;61(1):146-154. (PMID: 33187923) J Vasc Interv Radiol. 2021 Jun;32(6):792-801.e5. (PMID: 33677117) J Cardiol. 2021 May;77(5):435-443. (PMID: 33158714) Cardiovasc Interv Ther. 2022 Oct;37(4):597-612. (PMID: 35852760) Front Cardiovasc Med. 2020 Jul 31;7:119. (PMID: 32850981) Circ Cardiovasc Interv. 2020 May;13(5):e008869. (PMID: 32338525) Cardiovasc Interv Ther. 2026 Jul;41(3):680-689. (PMID: 42177329) JACC Cardiovasc Interv. 2015 Jan;8(1 Pt A):92-101. (PMID: 25499305) Eur Heart J. 2024 Sep 29;45(36):3538-3700. (PMID: 39210722) Eur J Prev Cardiol. 2024 May 11;31(7):803-811. (PMID: 38079162) J Vasc Interv Radiol. 2019 Jan;30(1):103-109. (PMID: 30527654) Circ J. 2015;79(12):2641-7. (PMID: 26489454) J Vasc Surg. 2024 Mar;79(3):584-592.e5. (PMID: 37931885) Nat Rev Cardiol. 2018 Jun;15(6):332-350. (PMID: 29679023) J Endovasc Ther. 2018 Feb;25(1):118-126. (PMID: 29161933) N Engl J Med. 2020 May 21;382(21):1994-2004. (PMID: 32222135) J Interv Cardiol. 2021 Jul 28;2021:5590109. (PMID: 34393666) Eur J Vasc Endovasc Surg. 2023 Nov;66(5):722-729. (PMID: 37516380) Lancet. 2019 Jun 22;393(10190):2503-2510. (PMID: 31056295) Cardiovasc Interv Ther. 2021 Jul;36(3):321-329. (PMID: 32601825) Circ J. 2018 Jul 25;82(8):2032-2040. (PMID: 29910223) Atherosclerosis. 2015 Nov;243(1):242-7. (PMID: 26408928) |
| Contributed Indexing: | Keywords: Drug-eluting stents; Endovascular treatment; Intravascular imaging; Peripheral artery disease; Stent failure |
| Entry Date(s): | Date Created: 20260729 Date Completed: 20260917 Latest Revision: 20260919 |
| Update Code: | 20260919 |
| PubMed Central ID: | PMC13582157 |
| DOI: | 10.1007/s12928-026-01321-y |
| PMID: | 42525227 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1868-4297 |
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| DOI: | 10.1007/s12928-026-01321-y |