Academic Journal
From rheumatology to dermatology: cytokine signaling pathways as therapeutic targets at the skin-joint interface in inflammatory diseases: a narrative review.
| Title: | From rheumatology to dermatology: cytokine signaling pathways as therapeutic targets at the skin-joint interface in inflammatory diseases: a narrative review. |
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| Authors: | Cattalini M; Pediatric Clinic University of Brescia and ASST Spedali Civili di Brescia, Brescia, Italy. Electronic address: marco.cattalini@unibs.it., Amerio P; Section of Dermatology, Department of Medicine and Aging Science, G. D'Annunzio University, Chieti, Italy., Bertolla D; Dermatologic Clinic AOC Ospedale Maggiore Parma, Parma, Italy; Section of Dermatology and Infectious Diseases, Department of Medical Sciences, University of Ferrara, Ferrara, Italy., Ruperto N; Università degli Studi Milano-Bicocca, Dipartimento di Medicina e Chirurgia, Monza, Italy; Fondazione IRCCS San Gerardo dei Tintori, Reumatologia Pediatrica, Fondazione PRINTO, Monza, Italy., Gualdi G; Dermatologic Clinic AOC Ospedale Maggiore Parma, Parma, Italy. |
| Corporate Authors: | Paediatric Rheumatology International Trials Organisation (PRINTO) and the Pediatric Rheumatology of the Milan and Lombardy Area (PRAGMA) |
| Source: | Current opinion in immunology [Curr Opin Immunol] 2026 Oct; Vol. 102, pp. 102830. Date of Electronic Publication: 2026 Jul 28. |
| Publication Type: | Journal Article; Review |
| Language: | English |
| Journal Info: | Publisher: Elsevier Country of Publication: England NLM ID: 8900118 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0372 (Electronic) Linking ISSN: 09527915 NLM ISO Abbreviation: Curr Opin Immunol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 1999- : London : Elsevier Original Publication: Philadelphia, PA, USA : Current Science, c1988- |
| MeSH Terms: | Cytokines*/metabolism , Skin*/immunology , Skin*/pathology , Skin*/metabolism , Inflammation*/immunology , Joints*/immunology , Joints*/pathology , Skin Diseases*, Signal Transduction/drug effects ; Humans ; Animals ; Molecular Targeted Therapy |
| Abstract: | Over the last two years, inflammatory dermatology has undergone a transition from morphology-based classification toward pathway-driven immune endotyping. Atopic dermatitis, psoriatic disease, and hidradenitis suppurativa have emerged as paradigmatic models of this transition, illustrating how epithelial dysfunction, involving autoinflammation and adaptive immunity, may lead to systemic inflammatory crosstalks, connecting cutaneous and musculoskeletal manifestations. Recent studies have refined the understanding of progressive immune maturation in atopic dermatitis, while psoriasis and juvenile psoriatic arthritis support skin-to-joint inflammatory models involving IL-23/IL-17 signaling. Hidradenitis suppurativa is increasingly recognized as a systemic autoinflammatory disease within a broader neutrophilic inflammatory spectrum. Parallel therapeutic advances involving IL-17, IL-23, TNF, and JAK inhibition reinforced the translational importance of these discoveries and accelerated the development of precision dermatology strategies. (Copyright © 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Substance Nomenclature: | 0 (Cytokines) |
| Entry Date(s): | Date Created: 20260728 Date Completed: 20260903 Latest Revision: 20260903 |
| Update Code: | 20260904 |
| DOI: | 10.1016/j.coi.2026.102830 |
| PMID: | 42520363 |
| Database: | MEDLINE |
| ISSN: | 1879-0372 |
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| DOI: | 10.1016/j.coi.2026.102830 |