Academic Journal
An astro-neural-field model with application to cortical spreading depolarization.
| Τίτλος: | An astro-neural-field model with application to cortical spreading depolarization. |
|---|---|
| Συγγραφείς: | Baspinar E; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France. emre.baspinar@inria.fr., Avitabile D; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France.; Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience - System and Network Neuroscience, Amsterdam, The Netherlands., Nouveau C; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France., Desroches M; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France., Campillo F; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France. fabien.campillo@inria.fr., Mantegazza M; Université Côte d'Azur, Valbonne-Sophia Antipolis, France.; CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France.; Inserm U1323, Valbonne-Sophia Antipolis, France. |
| Πηγή: | Journal of computational neuroscience [J Comput Neurosci] 2026 Sep; Vol. 54 (3), pp. 559-576. Date of Electronic Publication: 2026 Jul 28. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer US Country of Publication: United States NLM ID: 9439510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6873 (Electronic) Linking ISSN: 09295313 NLM ISO Abbreviation: J Comput Neurosci Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York : Springer US Original Publication: Boston : Kluwer Academic Publishers, 1994- |
| Ιατρικοί όροι (MeSH): | Cortical Spreading Depression*/physiology , Astrocytes*/physiology , Neurons*/physiology , Models, Neurological* , Cerebral Cortex*, Potassium/metabolism ; Membrane Potentials/physiology ; Migraine Disorders/physiopathology ; Humans ; Animals ; Nonlinear Dynamics |
| Περίληψη: | We present a novel astro-neural-field population model with application to migraine-related cortical spreading depolarization. The model is composed of four spatio-temporal state variables: excitatory and inhibitory membrane potentials, astrocytic potassium uptake recruitment, and extracellular potassium concentration. Extending a previous neural field model, we incorporate activity-dependent astrocytic potassium clearance via a nonlinear term coupled to astrocyte dynamics. The astrocyte transfer function, like its neural counterpart, exhibits three regimes governed by extracellular potassium, capturing its effect on clearance. This yields a more comprehensive framework, better fits experimental data, and provides new insights into the mechanisms of cortical spreading depolarization. (© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. |
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| Grant Information: | ANR-15-IDEX-01 Agence Nationale de la Recherche; LabEx ICST ANR- &&-LABX-0015-01 Laboratory of Excellence "Ion Channel Science and Therapeutics |
| Contributed Indexing: | Keywords: Astrocyte; Migraine; Neural field; Spreading depolarization |
| Substance Nomenclature: | RWP5GA015D (Potassium) |
| Entry Date(s): | Date Created: 20260728 Date Completed: 20260918 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s10827-026-00948-3 |
| PMID: | 42518050 |
| Βάση Δεδομένων: | MEDLINE |
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