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An astro-neural-field model with application to cortical spreading depolarization.

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Τίτλος: An astro-neural-field model with application to cortical spreading depolarization.
Συγγραφείς: Baspinar E; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France. emre.baspinar@inria.fr., Avitabile D; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France.; Department of Mathematics, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.; Amsterdam Neuroscience - System and Network Neuroscience, Amsterdam, The Netherlands., Nouveau C; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France., Desroches M; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France., Campillo F; MathNeuro Team, Inria Branch of the University of Montpellier, Montpellier, France. fabien.campillo@inria.fr., Mantegazza M; Université Côte d'Azur, Valbonne-Sophia Antipolis, France.; CNRS UMR7275, Institute of Molecular and Cellular Pharmacology (IPMC), Valbonne-Sophia Antipolis, France.; Inserm U1323, Valbonne-Sophia Antipolis, France.
Πηγή: Journal of computational neuroscience [J Comput Neurosci] 2026 Sep; Vol. 54 (3), pp. 559-576. Date of Electronic Publication: 2026 Jul 28.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer US Country of Publication: United States NLM ID: 9439510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-6873 (Electronic) Linking ISSN: 09295313 NLM ISO Abbreviation: J Comput Neurosci Subsets: MEDLINE
Imprint Name(s): Publication: New York : Springer US
Original Publication: Boston : Kluwer Academic Publishers, 1994-
Ιατρικοί όροι (MeSH): Cortical Spreading Depression*/physiology , Astrocytes*/physiology , Neurons*/physiology , Models, Neurological* , Cerebral Cortex*, Potassium/metabolism ; Membrane Potentials/physiology ; Migraine Disorders/physiopathology ; Humans ; Animals ; Nonlinear Dynamics
Περίληψη: We present a novel astro-neural-field population model with application to migraine-related cortical spreading depolarization. The model is composed of four spatio-temporal state variables: excitatory and inhibitory membrane potentials, astrocytic potassium uptake recruitment, and extracellular potassium concentration. Extending a previous neural field model, we incorporate activity-dependent astrocytic potassium clearance via a nonlinear term coupled to astrocyte dynamics. The astrocyte transfer function, like its neural counterpart, exhibits three regimes governed by extracellular potassium, capturing its effect on clearance. This yields a more comprehensive framework, better fits experimental data, and provides new insights into the mechanisms of cortical spreading depolarization.
(© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Conflict of interest: The authors declare no competing interests.
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Grant Information: ANR-15-IDEX-01 Agence Nationale de la Recherche; LabEx ICST ANR- &&-LABX-0015-01 Laboratory of Excellence "Ion Channel Science and Therapeutics
Contributed Indexing: Keywords: Astrocyte; Migraine; Neural field; Spreading depolarization
Substance Nomenclature: RWP5GA015D (Potassium)
Entry Date(s): Date Created: 20260728 Date Completed: 20260918 Latest Revision: 20261008
Update Code: 20261008
DOI: 10.1007/s10827-026-00948-3
PMID: 42518050
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1573-6873
DOI:10.1007/s10827-026-00948-3