Academic Journal
Phytochemical Characterisation and Skin-Relevant In Vitro Biological Activity of Leaf Extracts from Selected Geranium Species.
| Τίτλος: | Phytochemical Characterisation and Skin-Relevant In Vitro Biological Activity of Leaf Extracts from Selected Geranium Species. |
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| Συγγραφείς: | Książkiewicz M; Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, 3 Rokietnicka Str., 60-806 Poznan, Poland., Paluch E; Department of Microbiology, Faculty of Medicine, Wroclaw Medical University, 4 T. Chałubinskiego Str., 50-376 Wroclaw, Poland., Widelski J; Department of Pharmacognosy with Medicinal Plants Garden, Lublin Medical University, 20-093 Lublin, Poland., Stefanowicz-Hajduk J; Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, 107 Al. Gen. J. Hallera Str., 80-416 Gdańsk, Poland., Kochan-Jamrozy K; Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, 107 Al. Gen. J. Hallera Str., 80-416 Gdańsk, Poland., Bortkiewicz O; Department of Microbiology, Faculty of Medicine, Wroclaw Medical University, 4 T. Chałubinskiego Str., 50-376 Wroclaw, Poland., Wojtanowski KK; Department of Pharmacognosy with Medicinal Plants Garden, Lublin Medical University, 20-093 Lublin, Poland., Gucwa M; Department of Biology and Pharmaceutical Botany, Medical University of Gdańsk, 107 Al. Gen. J. Hallera Str., 80-416 Gdańsk, Poland., Cielecka-Piontek J; Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, 3 Rokietnicka Str., 60-806 Poznan, Poland., Studzińska-Sroka E; Department of Pharmacognosy and Biomaterials, Poznan University of Medical Sciences, 3 Rokietnicka Str., 60-806 Poznan, Poland. |
| Πηγή: | Molecules (Basel, Switzerland) [Molecules] 2026 Jul 08; Vol. 31 (14). Date of Electronic Publication: 2026 Jul 08. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, c1995- |
| Ιατρικοί όροι (MeSH): | Geranium*/chemistry , Plant Leaves*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/chemistry , Skin*/drug effects, Antioxidants/pharmacology ; Antioxidants/chemistry ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Anti-Infective Agents/pharmacology ; Anti-Infective Agents/chemistry ; Polyphenols/chemistry ; Polyphenols/pharmacology ; Fibroblasts/drug effects ; Humans ; Microbial Sensitivity Tests ; Cell Line |
| Περίληψη: | In the search for natural compounds with skin-relevant biological activity, the leaves from three species of the Geraniaceae family (Geranium phaeum, Geranium sanguineum, and Geranium macrorrhizum) were investigated. The study combined phytochemical characterisation with a broad evaluation of biological activity. The bioactivity of the tested extracts was assessed using antioxidant assays (DPPH, ABTS, and CUPRAC), metal-chelating tests, and inhibition assays of hyaluronidase, elastase, and tyrosinase. In addition, antimicrobial activity was evaluated against selected Gram-positive and Gram-negative bacteria and Candida spp., while cytocompatibility was assessed using HaCaT keratinocytes and HFF-1 fibroblasts. To support the interpretation of the observed biological effects, qualitative phytochemical profiling of the extracts was performed by LC-MS; selected compounds were quantified by HPLC; and total polyphenol and flavonoid contents (TPC and TFC) were determined. Overall, the extracts exhibited notable antioxidant, antimicrobial, and enzyme-inhibitory activities, while maintaining good cytocompatibility at lower concentrations. Among the tested species, G. sanguineum and G. macrorrhizum showed the most pronounced overall activity, likely associated with their high polyphenol content. These results indicate that selected Geraniaceae species represent promising sources of bioactive compounds with combined antioxidant, antimicrobial, and skin-compatible properties, supporting their further investigation in skin-relevant in vitro and formulation-oriented studies. |
| Contributed Indexing: | Keywords: Geranium leaves; antimicrobial activity; antioxidant activity; cytocompatibility; plant extracts; skin-related enzyme inhibition |
| Substance Nomenclature: | 0 (Plant Extracts) 0 (Antioxidants) 0 (Phytochemicals) 0 (Flavonoids) 0 (Anti-Infective Agents) 0 (Polyphenols) |
| Entry Date(s): | Date Created: 20260728 Date Completed: 20260729 Latest Revision: 20260731 |
| Update Code: | 20260731 |
| PubMed Central ID: | PMC13416177 |
| DOI: | 10.3390/molecules31142406 |
| PMID: | 42513091 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1420-3049 |
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| DOI: | 10.3390/molecules31142406 |