Academic Journal
Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms.
| Τίτλος: | Exploring the Relationship Between Hearing Loss and Cognitive Dysfunction from the Perspective of Molecular Mechanisms. |
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| Συγγραφείς: | Wang L; Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Clinical Medical Research Center of Deafness and Vertigo in Hubei Province, Wuhan 430022, China., Zhou Z; Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Clinical Medical Research Center of Deafness and Vertigo in Hubei Province, Wuhan 430022, China., Shen X; Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Clinical Medical Research Center of Deafness and Vertigo in Hubei Province, Wuhan 430022, China., Wu G; Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Clinical Medical Research Center of Deafness and Vertigo in Hubei Province, Wuhan 430022, China., Chen X; Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Clinical Medical Research Center of Deafness and Vertigo in Hubei Province, Wuhan 430022, China., Liu B; Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Clinical Medical Research Center of Deafness and Vertigo in Hubei Province, Wuhan 430022, China., Xiao H; Department of Otorhinolaryngology-Head and Neck Surgery, ENT Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; Clinical Medical Research Center of Deafness and Vertigo in Hubei Province, Wuhan 430022, China. |
| Πηγή: | Biomolecules [Biomolecules] 2026 Jul 04; Vol. 16 (7). Date of Electronic Publication: 2026 Jul 04. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101596414 Publication Model: Electronic Cited Medium: Internet ISSN: 2218-273X (Electronic) Linking ISSN: 2218273X NLM ISO Abbreviation: Biomolecules Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Basel, Switzerland : MDPI, 2011- |
| Ιατρικοί όροι (MeSH): | Hearing Loss*/metabolism , Hearing Loss*/complications , Hearing Loss*/pathology , Cognitive Dysfunction*/metabolism , Cognitive Dysfunction*/complications , Cognitive Dysfunction*/pathology, tau Proteins/metabolism ; Amyloid beta-Peptides/metabolism ; Reactive Oxygen Species/metabolism ; Brain-Derived Neurotrophic Factor/metabolism ; gamma-Aminobutyric Acid/metabolism ; Glutamic Acid/metabolism ; Humans ; Animals |
| Περίληψη: | Dementia is primarily characterized by cognitive dysfunction, which is one of the major causes of disability. As hearing loss has been identified as the largest modifiable risk factor for dementia, understanding the intrinsic relationship between the two is crucial for preventing and mitigating the progression of dementia. A body of research has demonstrated a close association between hearing loss and morphological changes in the brain; however, the underlying molecular mechanisms require further elucidation. This review synthesizes current evidence on tau protein, amyloid beta protein, glutamate, gamma-aminobutyric acid, reactive oxygen species, and brain-derived neurotrophic factor to clarify potential molecular pathways linking hearing loss with cognitive dysfunction and to identify candidate targets for future mechanistic and translational studies. |
| Grant Information: | Nos. 2023YFC2508400, 2023YFC2508000, and 2023YFC2508001 National Key Research and Development Program of China; No. 2021CFB547 Natural Science Foundation of Hubei Province |
| Contributed Indexing: | Keywords: cognitive dysfunction; hearing loss; molecular mechanism; tau protein |
| Substance Nomenclature: | 0 (tau Proteins) 0 (Amyloid beta-Peptides) 0 (Reactive Oxygen Species) 0 (Brain-Derived Neurotrophic Factor) 56-12-2 (gamma-Aminobutyric Acid) 3KX376GY7L (Glutamic Acid) |
| Entry Date(s): | Date Created: 20260728 Date Completed: 20260729 Latest Revision: 20260730 |
| Update Code: | 20260730 |
| PubMed Central ID: | PMC13406282 |
| DOI: | 10.3390/biom16070986 |
| PMID: | 42509780 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2218-273X |
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| DOI: | 10.3390/biom16070986 |