Academic Journal
Transcriptomic changes in the jerboa supraoptic nucleus during osmotic stress: PCSK1 and PTPRN changes are conserved across desert and mesic species.
| Τίτλος: | Transcriptomic changes in the jerboa supraoptic nucleus during osmotic stress: PCSK1 and PTPRN changes are conserved across desert and mesic species. |
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| Συγγραφείς: | Gillard BT; Molecular Neuroendocrinology Research Group, Bristol Medical School, Translational Health Sciences, Dorothy Hodgkin Building, University of Bristol, Bristol, UK., Amor N; LR22ES04, Research Laboratory of Bioresources, Environment and Biotechnology (BeB), University of Tunis El Manar, Tunis, Tunisia., Greenwood MP; School of Psychology and Neuroscience, University of Bristol, Bristol, UK., Alagaili AN; Department of Zoology, King Saud University, Riyadh, Kingdom of Saudi Arabia., Murphy D; School of Psychology and Neuroscience, University of Bristol, Bristol, UK. |
| Πηγή: | Journal of neuroendocrinology [J Neuroendocrinol] 2026 Aug; Vol. 38 (8), pp. e70233. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley & Sons Country of Publication: United States NLM ID: 8913461 Publication Model: Print Cited Medium: Internet ISSN: 1365-2826 (Electronic) Linking ISSN: 09538194 NLM ISO Abbreviation: J Neuroendocrinol Subsets: MEDLINE |
| Imprint Name(s): | Publication: <2010->: Malden, MA : Wiley & Sons Original Publication: Eynsham, Oxon, UK : Oxford University Press, c1989- |
| Ιατρικοί όροι (MeSH): | Supraoptic Nucleus*/metabolism , Osmotic Pressure*/physiology , Proprotein Convertase 1*/metabolism , Proprotein Convertase 1*/genetics , Transcriptome*, Dehydration/metabolism ; Dehydration/genetics ; Osmoregulation/genetics ; Animals ; Male ; Female ; Species Specificity ; Desert Climate |
| Περίληψη: | The supraoptic nucleus (SON) is a hypothalamic region essential for the orchestration of osmoregulation in mammals. We sought to understand how gene expression in the SON is orchestrated in a rodent species adapted for survival in arid desert conditions. After an acclimatisation period, we compared the male and female trancriptomes of the Lesser Egyptian jerboa (Jaculus jaculus) SON under euhydrated, dehydrated, and rehydrated conditions. Gene expression in the jerboa SON was remarkably stable across the conditions with only 46 differentially expressed genes (DEGs) after dehydration and 4 DEGs after rehydration compared to controls; far fewer than previously shown to respond in the jerboa kidney and in the SON of mesic species. When comparing across species (jerboa, camel, and rat), the genes PCSK1 and PTPRN were consistently regulated under conditions of osmotic stress suggesting they have important conserved functions. The dehydration response in jerboa SON is tightly regulated. PCSK1 and PTPRN are identified as conserved components of the response, indicating their importance. (© 2026 The Author(s). Journal of Neuroendocrinology published by John Wiley & Sons Ltd on behalf of British Society for Neuroendocrinology.) |
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| Grant Information: | RPG-2017287 Leverhulme Trust; BB/R016879/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; BB/M009122/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; EP/K008250/1 Engineering and Physical Sciences Research Council; ORF-2025-602 Ongoing Research Funding Program |
| Contributed Indexing: | Keywords: Jaculus jaculus; WGCNA; cross species comparison; osmoregulation; supraoptic nucleus |
| Substance Nomenclature: | EC 3.4.21.93 (Proprotein Convertase 1) |
| Entry Date(s): | Date Created: 20260726 Date Completed: 20260726 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13402333 |
| DOI: | 10.1111/jne.70233 |
| PMID: | 42503567 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1365-2826 |
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| DOI: | 10.1111/jne.70233 |