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Nature's Hidden Arsenal: Unveiling the Anticancer Potential of Eugenia Species.

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Τίτλος: Nature's Hidden Arsenal: Unveiling the Anticancer Potential of Eugenia Species.
Συγγραφείς: Pereira MTM; Research Laboratory on Natural Products and Bioactive Molecules, Health Institute, Federal Fluminense University, Nova Friburgo, Rio de Janeiro, Brazil., Charret TS; Research Laboratory on Natural Products and Bioactive Molecules, Health Institute, Federal Fluminense University, Nova Friburgo, Rio de Janeiro, Brazil., Thurler-Júnior JC; Research Laboratory on Natural Products and Bioactive Molecules, Health Institute, Federal Fluminense University, Nova Friburgo, Rio de Janeiro, Brazil., Severino P; Biotechnological Postgraduate Program, Tiradentes University, Aracaju, Sergipe, Brazil., Souto EB; UCD School of Chemical and Bioprocess Engineering, University College Dublin, Belfield, Ireland., Pascoal VDB; Research Laboratory on Natural Products and Bioactive Molecules, Health Institute, Federal Fluminense University, Nova Friburgo, Rio de Janeiro, Brazil., Pascoal ACRF; Research Laboratory on Natural Products and Bioactive Molecules, Health Institute, Federal Fluminense University, Nova Friburgo, Rio de Janeiro, Brazil.
Πηγή: Chemistry & biodiversity [Chem Biodivers] 2026 Jul; Vol. 23 (7), pp. e71517.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Verlag Helvetica Chimica Acta Country of Publication: Switzerland NLM ID: 101197449 Publication Model: Print Cited Medium: Internet ISSN: 1612-1880 (Electronic) Linking ISSN: 16121872 NLM ISO Abbreviation: Chem Biodivers Subsets: MEDLINE
Imprint Name(s): Original Publication: Zürich, Switzerland : Hoboken, NJ : Verlag Helvetica Chimica Acta ; Distributed in the USA by Wiley, c2004-
Ιατρικοί όροι (MeSH): Antineoplastic Agents, Phytogenic*/chemistry , Antineoplastic Agents, Phytogenic*/pharmacology , Antineoplastic Agents, Phytogenic*/isolation & purification , Eugenia*/chemistry , Neoplasms*/drug therapy , Neoplasms*/pathology , Neoplasms*/metabolism , Phytochemicals*/chemistry , Phytochemicals*/pharmacology , Phytochemicals*/isolation & purification , Plant Extracts*/chemistry , Plant Extracts*/pharmacology , Plant Extracts*/isolation & purification , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/chemistry, Apoptosis/drug effects ; Cell Proliferation/drug effects ; Humans ; Animals
Περίληψη: The genus Eugenia comprises approximately 1050 species widely used in traditional medicine and human nutrition due to their diverse pharmacological properties. This review aimed to critically summarize the anticancer potential of Eugenia species and to correlate their biological activities with the presence of bioactive phytochemicals. Literature published between 2013 and 2025 was retrieved from PubMed, SciELO, and Google Scholar databases using terms related to Eugenia, cancer, antiproliferative, and cytotoxic activities. Increasing evidence has demonstrated the anticancer effects of selected Eugenia species in in silico, in vitro, and in vivo models against different cancer types. These effects are associated with multiple mechanisms, including apoptosis induction via caspase-3/7 activation and Fas receptor upregulation, inhibition of tumor cell migration and invasion through suppression of MMP-2 and MMP-9, and cell cycle arrest. The observed activities are closely related to the presence of flavonoids, phenolic acids, carotenoids, monoterpenes, triterpenes, and sesquiterpenes. Despite promising preclinical findings, limitations such as the scarcity of in vivo studies, lack of extract standardization, and absence of clinical trials still hinder the translational application of Eugenia-derived compounds in oncology. Future studies focusing on mechanistic elucidation, bioavailability, toxicity, and clinical validation are essential for the development of Eugenia-based anticancer therapies.
(© 2026 Wiley‐VHCA AG.)
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Contributed Indexing: Keywords: anticancer activity; bioactive compounds; eugenia; myrtaceae; phytochemistry; plant extracts
Substance Nomenclature: 0 (Antineoplastic Agents, Phytogenic)
0 (Phytochemicals)
0 (Plant Extracts)
0 (Antineoplastic Agents)
Entry Date(s): Date Created: 20260726 Date Completed: 20260726 Latest Revision: 20260729
Update Code: 20260729
PubMed Central ID: PMC13401969
DOI: 10.1002/cbdv.71517
PMID: 42503199
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1612-1880
DOI:10.1002/cbdv.71517