Academic Journal
MOF-SERS hybrid architecture integrated on Fiber-Optic probes for quantification of plasma dopamine in human blood.
| Τίτλος: | MOF-SERS hybrid architecture integrated on Fiber-Optic probes for quantification of plasma dopamine in human blood. |
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| Συγγραφείς: | Vo TBN; Department of Chemical and Biological Engineering, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si, 13120, South Korea., Kim JH; Department of Psychiatry, Gachon University College of Medicine, Gil Medical Center, Neuroscience Research Institute, Gachon University, Incheon, 21565, South Korea. Electronic address: jhnp@gachon.ac.kr., Lee SW; Department of Chemical and Biological Engineering, Gachon University, 1342 Seongnamdaero, Sujeong-gu, Seongnam-si, 13120, South Korea. Electronic address: lswha@gachon.ac.kr. |
| Πηγή: | Biosensors & bioelectronics [Biosens Bioelectron] 2026 Nov 15; Vol. 312, pp. 119068. Date of Electronic Publication: 2026 Jul 24. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Advanced Technology Country of Publication: England NLM ID: 9001289 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4235 (Electronic) Linking ISSN: 09565663 NLM ISO Abbreviation: Biosens Bioelectron Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Elsevier Advanced Technology Original Publication: [Barking, Essex, England] : Elsevier Applied Science, 1989- |
| Ιατρικοί όροι (MeSH): | Dopamine*/blood , Biosensing Techniques*/instrumentation , Fiber Optic Technology*/instrumentation, Gold/chemistry ; Silver/chemistry ; Spectrum Analysis, Raman/methods ; Metal Nanoparticles/chemistry ; Humans ; Limit of Detection ; Optical Fibers |
| Περίληψη: | Dopamine (DA) is an essential neurochemical marker, yet its reliable quantification in complex biofluids remains challenging for fiber-based sensors due to limited signal return and bio-interference. Here, we present a MOF-SERS hybrid architecture integrated onto a fiber-optic probe for DA detection in human plasma. The platform employs polyhedral Au@Ag nanostars coated with an ultrathin MIL-100(Fe) shell, enabling synergistic plasmonic amplification and molecular enrichment at the sensing interface. This engineered interface delivers a high SERS enhancement factor of 3.2 × 108, an ultralow detection limit of 1.22 × 10-10 M, and excellent linearity (R2 = 0.988), while maintaining selectivity against competing neurotransmitters. Importantly, this system enables direct, quantification of DA in human plasma, demonstrating practical applicability in real samples, not previously reported, yielding physiologically relevant concentrations (1.43 × 10-9 M). These results establish the MOF-SERS-integrated fiber probe as a potential powerful platform for remote and flexible neurochemical sensing in complex biological matrices, with strong promising for clinically relevant bioanalysis. (Copyright © 2026 Elsevier B.V. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Dopamine; Metal-organic frameworks; Optical fiber; Surface-enhanced Raman scattering; Ultrasensitive detection |
| Substance Nomenclature: | VTD58H1Z2X (Dopamine) 7440-57-5 (Gold) 3M4G523W1G (Silver) |
| Entry Date(s): | Date Created: 20260725 Date Completed: 20260812 Latest Revision: 20260812 |
| Update Code: | 20260813 |
| DOI: | 10.1016/j.bios.2026.119068 |
| PMID: | 42501482 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-4235 |
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| DOI: | 10.1016/j.bios.2026.119068 |