Academic Journal
Perioperative Systemic Treatment Patterns and Postoperative Mortality Among Patients With Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy in Japan: WAKKA-MIBC Study.
| Τίτλος: | Perioperative Systemic Treatment Patterns and Postoperative Mortality Among Patients With Muscle-Invasive Bladder Cancer Undergoing Radical Cystectomy in Japan: WAKKA-MIBC Study. |
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| Συγγραφείς: | Kikuchi E; Department of Urology, St. Marianna University School of Medicine, Kawasaki, Kanagawa, Japan., Tokumaru J; Medical Department, Astra Zeneca K.K., Tokyo, Japan., Kawai D; Medical Department, Astra Zeneca K.K., Tokyo, Japan., Ide R; Medical Department, Astra Zeneca K.K., Tokyo, Japan., Komazaki H; Medical Department, Astra Zeneca K.K., Tokyo, Japan., Kitagawa H; Medical Department, Astra Zeneca K.K., Tokyo, Japan., Inokuchi J; Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan. |
| Πηγή: | International journal of urology : official journal of the Japanese Urological Association [Int J Urol] 2026 Jul; Vol. 33 (7), pp. e70565. |
| Τύπος έκδοσης: | Journal Article; Observational Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Science Asia Country of Publication: Australia NLM ID: 9440237 Publication Model: Print Cited Medium: Internet ISSN: 1442-2042 (Electronic) Linking ISSN: 09198172 NLM ISO Abbreviation: Int J Urol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Carlton South, Vic. : Blackwell Science Asia Original Publication: Tokyo ; New York : Churchill Livingstone, c1994- |
| Ιατρικοί όροι (MeSH): | Urinary Bladder Neoplasms*/mortality , Urinary Bladder Neoplasms*/pathology , Urinary Bladder Neoplasms*/therapy , Urinary Bladder Neoplasms*/surgery , Cystectomy*/methods , Neoadjuvant Therapy*/trends , Neoadjuvant Therapy*/statistics & numerical data , Neoadjuvant Therapy*/methods , Antineoplastic Combined Chemotherapy Protocols*/therapeutic use, Japan/epidemiology ; Chemotherapy, Adjuvant/trends ; Chemotherapy, Adjuvant/statistics & numerical data ; Deoxycytidine/analogs & derivatives ; Deoxycytidine/administration & dosage ; Cisplatin/administration & dosage ; Humans ; Female ; Retrospective Studies ; Male ; Aged ; Neoplasm Invasiveness ; Middle Aged ; Neoplasm Staging ; Gemcitabine |
| Περίληψη: | Objectives: To characterize the temporal changes in perioperative systemic treatment patterns and postoperative mortality among Japanese patients with stage II-III muscle-invasive bladder cancer (MIBC) undergoing radical cystectomy (RC) from 2013 to 2024. Methods: This retrospective observational cohort study assessed neoadjuvant chemotherapy (NAC) and adjuvant therapy (AT) relative to RC. Treatment patterns (NAC + RC + AT, NAC + RC, RC + AT, and RC alone), NAC regimen selection, and 30- and 90-day postoperative mortality were evaluated across three periods (2013-2017, 2018-2021, and 2022-2024). Analyses were descriptive. Results: Among 5 208 patients, the use of NAC + RC increased from 31.4% in 2013-2017 to 50.4% in 2022-2024, and the use of NAC + RC + AT increased from 8.7% to 22.4%. RC alone decreased from 46.3% to 21.4%. Reduced-dose gemcitabine + cisplatin (GC) and gemcitabine + carboplatin were frequently used and remained common throughout the study period. In 2022-2024, 18.8% of patients received adjuvant nivolumab; most had received NAC beforehand (242/270). The 30- and 90-day mortality remained low regardless of the increase in NAC use (30-day: ≤ 0.2% with NAC vs. ≤ 1.5% without; 90-day: ≤ 1.4% with NAC vs. ≤ 3.3% without). Conclusions: Perioperative systemic therapy for MIBC in Japan has intensified over the past decade, with increased adoption of NAC and adjuvant nivolumab. Dose-modified GC and carboplatin-based regimens have remained commonly used throughout the study period. Even with increased NAC use, postoperative mortality has remained low. (© 2026 Astra Zeneca K.K. The Author(s). International Journal of Urology published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Urological Association.) |
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| Grant Information: | AstraZeneca K.K. |
| Contributed Indexing: | Keywords: cystectomy; database; neoadjuvant therapy; retrospective studies; urinary bladder neoplasms |
| Substance Nomenclature: | 0W860991D6 (Deoxycytidine) 0 (Gemcitabine) Q20Q21Q62J (Cisplatin) |
| Entry Date(s): | Date Created: 20260725 Date Completed: 20260725 Latest Revision: 20260728 |
| Update Code: | 20260729 |
| PubMed Central ID: | PMC13401184 |
| DOI: | 10.1111/iju.70565 |
| PMID: | 42499313 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1442-2042 |
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| DOI: | 10.1111/iju.70565 |