Academic Journal
Detection of metastasis in myxoid liposarcoma: WB-MRI versus CT-CAP.
| Τίτλος: | Detection of metastasis in myxoid liposarcoma: WB-MRI versus CT-CAP. |
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| Συγγραφείς: | Khurram R; Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK. ruhaidk@gmail.com., Chua E; Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK., Sait MS; Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK., Rajakulasingam R; Department of Radiology, Royal National Orthopaedic Hospital, Brockley Hill, Stanmore, Middlesex, HA7 4LP, UK. |
| Πηγή: | Skeletal radiology [Skeletal Radiol] 2026 Nov; Vol. 55 (11), pp. 2791-2800. Date of Electronic Publication: 2026 Jul 24. |
| Τύπος έκδοσης: | Journal Article; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Verlag Country of Publication: Germany NLM ID: 7701953 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-2161 (Electronic) Linking ISSN: 03642348 NLM ISO Abbreviation: Skeletal Radiol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Berlin : Springer Verlag Original Publication: Berlin, New York, Springer International. |
| Ιατρικοί όροι (MeSH): | Liposarcoma, Myxoid*/diagnostic imaging , Liposarcoma, Myxoid*/pathology , Liposarcoma, Myxoid*/secondary , Magnetic Resonance Imaging*/methods , Tomography, X-Ray Computed*/methods , Whole Body Imaging*/methods , Bone Neoplasms*/diagnostic imaging , Bone Neoplasms*/secondary , Neoplasm Metastasis*/diagnostic imaging, Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/secondary ; Pelvis/diagnostic imaging ; Humans ; Female ; Middle Aged ; Retrospective Studies ; Male ; Neoplasm Staging ; Adult ; Aged |
| Περίληψη: | Objective: To describe the incidence and distribution of skeletal and extraskeletal metastases in myxoid liposarcoma (MLS) on staging whole-body MRI (WB-MRI) and CT chest, abdomen, and pelvis (CT-CAP), to inform initial staging protocols. Materials and Methods: Retrospective review of staging WB-MRI and CT-CAP performed within 60 days in 57 histologically proven MLS cases at a quaternary sarcoma center (October 2018 to August 2022). Findings were classified by consensus as normal, indeterminate, or metastasis (bone, lung, and soft tissue). Primary tumor characteristics were compared between metastatic and nonmetastatic cases. Results: Fifty-seven patients (25 female, 32 male; mean age 46 years) comprised 55 new diagnoses and two recurrences. Median WB-MRI to CT-CAP interval was 0 days (IQR 0 to 8). Among new diagnoses, WB-MRI classified 76% as normal, 13% indeterminate, and 11% metastatic; CT-CAP proportions were 82%, 11%, and 7%. All bone metastases and indeterminate osseous lesions on WB-MRI were occult on CT-CAP or outside the CT field of view (FOV). All extrapulmonary soft tissue lesions within the CT FOV were seen on both. Small pulmonary nodules (< 5 mm) were seen only on CT. All metastases occurred in deep tumors; mean maximum dimension and volume were significantly larger with metastases (19.3 vs. 10.6 cm, p = 0.035; 1566 vs. 399 cm3, p = 0.007). Conclusion: Osseous metastases and indeterminate lesions were more frequent on WB-MRI than CT-CAP, whereas extrapulmonary soft tissue metastases were seen on both within the CT FOV. CT chest retained value for small pulmonary nodules. These findings support prospective evaluation of WB-MRI plus CT chest for initial staging in MLS. (© 2026. The Author(s), under exclusive licence to International Skeletal Society (ISS).) |
| Competing Interests: | Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Conflict of interest: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Computed tomography; Liposarcoma; Metastasis; Myxoid; Staging; Whole-body MRI |
| Entry Date(s): | Date Created: 20260724 Date Completed: 20260914 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1007/s00256-026-05307-y |
| PMID: | 42498840 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1432-2161 |
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| DOI: | 10.1007/s00256-026-05307-y |