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Clinical features associated with Pseudomonas aeruginosa colonization in children under 2 years of age: a retrospective study of Cystic Fibrosis Registry.

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Title: Clinical features associated with Pseudomonas aeruginosa colonization in children under 2 years of age: a retrospective study of Cystic Fibrosis Registry.
Authors: Ocak E; Department of Pediatric Pulmonology, Ministry of Health Ankara City Hospital, Ankara, Türkiye., Cinel G; Department of Pediatric Pulmonology, Ministry of Health Ankara City Hospital, Ankara, Türkiye., Tuğcu GD; Department of Pediatric Pulmonology, Ministry of Health Ankara City Hospital, Ankara, Türkiye., Polat SE; Department of Pediatric Pulmonology, Ministry of Health Ankara City Hospital, Ankara, Türkiye., Tural DA; Department of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Özsezen B; Department of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Yalçın E; Department of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Kiper N; Department of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Şen V; Department of Pediatric Pulmonology, Faculty of Medicine, Dicle University, Diyarbakır, Türkiye., Şen HS; Department of Chest Diseases, Faculty of Medicine, Dicle University, Diyarbakır, Türkiye., Altıntaş DU; Department of Pediatric Allergy and Immunology, Faculty of Medicine, Çukurova University, Adana, Türkiye., Kılınç AA; Department of Pediatric Pulmonology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Türkiye., Çokuğraş H; Department of Pediatric Pulmonology, Cerrahpaşa Faculty of Medicine, İstanbul University-Cerrahpaşa, İstanbul, Türkiye., Yazan H; Department of Pediatric Pulmonology, Faculty of Medicine, Bezmialem Vakıf University, İstanbul, Türkiye., Ünal G; Department of Pediatric Pulmonology, Meram Medicine Faculty, Necmettin Erbakan University, Konya, Türkiye., Yılmaz Aİ; Department of Pediatric Pulmonology, Meram Medicine Faculty, Necmettin Erbakan University, Konya, Türkiye., Irmak I; Department of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Damadoğlu E; Department of Chest Diseases, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Öztürk GK; Department of Pediatric Pulmonology, Faculty of Medicine, Ege University, İzmir, Türkiye., Demir E; Department of Pediatric Pulmonology, Faculty of Medicine, Ege University, İzmir, Türkiye., Başaran E; Department of Pediatric Pulmonology, Faculty of Medicine, Akdeniz University, Antalya, Türkiye., Bingöl A; Department of Pediatric Pulmonology, Faculty of Medicine, Akdeniz University, Antalya, Türkiye., Sapan N; Department of Pediatric Allergy and Immunology, Faculty of Medicine, Bursa Uludağ University, Bursa, Türkiye., Canıtez Y; Department of Pediatric Allergy and Immunology, Faculty of Medicine, Bursa Uludağ University, Bursa, Türkiye., Asfuroğlu P; Department of Pediatric Pulmonology, Faculty of Medicine, Gazi University, Ankara, Türkiye., Aslan AT; Department of Pediatric Pulmonology, Faculty of Medicine, Gazi University, Ankara, Türkiye., Harmancı K; Department of Pediatric Allergy and Immunology, Faculty of Medicine, Osmangazi University, Eskişehir, Türkiye., Hangül M; Department of Pediatric Pulmonology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye., Köse M; Department of Pediatric Pulmonology, Faculty of Medicine, Erciyes University, Kayseri, Türkiye., Özdemir A; Department of Pediatric Pulmonology, Ministry of Health Mersin City Hospital, Mersin, Türkiye., Özcan G; Department of Pediatric Pulmonology, Faculty of Medicine, Ankara University, Ankara, Türkiye., Çobanoğlu N; Department of Pediatric Pulmonology, Faculty of Medicine, Ankara University, Ankara, Türkiye., Aydın ZGG; Department of Pediatric Infectious Diseases, Faculty of Medicine, Karadeniz Technical University, Trabzon, Türkiye., Keskin Ö; Department of Pediatric Allergy and Immunology, Faculty of Medicine, Gaziantep University, Gaziantep, Türkiye., Yüksel H; Department of Pediatric Allergy and Immunology, Faculty of Medicine, Celal Bayar University, Manisa, Türkiye., Özdoğan Ş; Department of Pediatric Pulmonology, Şişli Hamidiye Etfal Research and Training Hospital, İstanbul, Türkiye., Topal E; Department of Pediatric Allergy, Faculty of Medicine, İnönü University, Malatya, Türkiye., Çaltepe G; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, Ondokuz Mayıs University, Samsun, Türkiye., Can D; Department of Pediatric Pulmonology, Faculty of Medicine, Balıkesir University, Balıkesir, Türkiye., Korkmaz P; Department of Chest Diseases, Faculty of Medicine, Ege University, Izmir, Türkiye., Kılıç M; Department of Pediatric Pulmonology, Faculty of Medicine, Ege University, İzmir, Türkiye., Eyüboğlu TŞ; Department of Pediatric Pulmonology, Faculty of Medicine, Gazi University, Ankara, Türkiye., Pekcan S; Department of Pediatric Pulmonology, Meram Medicine Faculty, Necmettin Erbakan University, Konya, Türkiye., Çakır E; Department of Pediatric Pulmonology, Faculty of Medicine, İstinye University, İstanbul, Türkiye., Emiralioğlu N; Department of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Özçelik U; Department of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye., Doğru D; Department of Pediatric Pulmonology, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Source: The Turkish journal of pediatrics [Turk J Pediatr] 2026 Jun 30; Vol. 68 (3), pp. 439-449. Date of Electronic Publication: 2026 Jun 30.
Publication Type: Journal Article
Language: English
Journal Info: Publisher: Hacettepe University, Institute of Child Health Country of Publication: Turkey NLM ID: 0417505 Publication Model: Electronic Cited Medium: Internet ISSN: 2791-6421 (Electronic) Linking ISSN: 00414301 NLM ISO Abbreviation: Turk J Pediatr Subsets: MEDLINE
Imprint Name(s): Publication: Ankara : Hacettepe University, Institute of Child Health
Original Publication: Ankara : Hacettepe Medical Center
MeSH Terms: Cystic Fibrosis*/microbiology , Cystic Fibrosis*/complications , Cystic Fibrosis*/genetics , Pseudomonas aeruginosa*/isolation & purification , Pseudomonas Infections*/epidemiology , Pseudomonas Infections*/diagnosis, Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Humans ; Retrospective Studies ; Female ; Infant ; Male ; Registries ; Cross-Sectional Studies ; Infant, Newborn
Abstract: Background: Respiratory colonization with Pseudomonas aeruginosa is associated with increased morbidity and mortality in cystic fibrosis (CF) patients. This study aims to assess the clinical characteristics and associated factors of CF infants under two years of age with P. aeruginosa colonization in Türkiye.
Method: Of the 1637 patients registered in the Cystic Fibrosis Registry of Türkiye in 2019, 284 patients under two years of age were included in this retrospective cross-sectional study. Patients were classified into two groups: those with P. aeruginosa colonization (Group 1) and those without (Group 2). Cystic fibrosis transmembrane conductance regulator (CFTR) gene functions were categorized according to CFTR mutation functional class.
Results: Twenty-three patients (8.1%) were categorized as Group 1 and 262 participants (91.9%) were classified as Group 2. Infants with P. aeruginosa colonization (Group 1) were more likely to have minimal CFTR function compared with those without colonization (87% vs. 39.8%, p = 0.017). In addition, both Staphylococcus aureus colonization (47.8% vs. 7.3%, p < 0.001) and methicillin-resistant S. aureus positivity (17.4% vs. 6.1%, p = 0.042) were observed more commonly in Group 1. There were no statistical differences between the groups in terms of age at diagnosis, gender, mean z-scores of weight and height, newborn screening test positivity, sweat chloride test results, and pancreatic insufficiency (p > 0.05). Univariate logistic regression analysis did not identify significant associated factors for P. aeruginosa colonization.
Conclusions: Our findings suggest that minimal CFTR function and S. aureus colonization are associated with P. aeruginosa colonization in CF patients under two years of age. Further studies are needed to investigate associated factors for early P. aeruginosa colonization, eradication treatment effectiveness, and longitudinal outcomes of in CF patients under two years of age.
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Contributed Indexing: Keywords: Cystic fibrosis; Pseudomonas aeruginosa; children; colonization; registry
Substance Nomenclature: 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator)
Entry Date(s): Date Created: 20260724 Date Completed: 20260724 Latest Revision: 20260724
Update Code: 20260725
DOI: 10.24953/turkjpediatr.2026.7593
PMID: 42497434
Database: MEDLINE
Description
ISSN:2791-6421
DOI:10.24953/turkjpediatr.2026.7593