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Phytochemicals as Natural Therapeutics Against Helicobacter pylori: A Comprehensive Review.

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Τίτλος: Phytochemicals as Natural Therapeutics Against Helicobacter pylori: A Comprehensive Review.
Συγγραφείς: Shah SAR; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan. ali.raza@imbb.uol.edu.pk., Jamil H; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Mustafa I; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Sharif S; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Zahid Z; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Yasir A; Institute of Molecular Biology and Biotechnology (IMBB), The University of Lahore, Lahore, Pakistan., Nayila I; Department of Pharmacy, The University of Lahore, Sargodha Campus, Sargodha, Pakistan.
Πηγή: Current microbiology [Curr Microbiol] 2026 Jul 23; Vol. 83 (9). Date of Electronic Publication: 2026 Jul 23.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer International Country of Publication: United States NLM ID: 7808448 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-0991 (Electronic) Linking ISSN: 03438651 NLM ISO Abbreviation: Curr Microbiol Subsets: MEDLINE
Imprint Name(s): Original Publication: New York, Springer International.
Ιατρικοί όροι (MeSH): Helicobacter pylori*/drug effects , Helicobacter pylori*/physiology , Phytochemicals*/pharmacology , Phytochemicals*/therapeutic use , Phytochemicals*/chemistry , Helicobacter Infections*/drug therapy , Helicobacter Infections*/microbiology , Anti-Bacterial Agents*/pharmacology , Anti-Bacterial Agents*/therapeutic use , Anti-Bacterial Agents*/chemistry, Biofilms/drug effects ; Plants, Medicinal/chemistry ; Humans ; Drug Resistance, Bacterial
Περίληψη: Helicobacter pylori is considered as a high-priority pathogen by World Health Organization which causes chronic gastritis and peptic ulcer disease and gastric carcinoma. The organism uses several methods to establish its disease-causing ability through urease production CagA protein synthesis biofilm development and ongoing gastric tissue damage. The rising rates of antibiotic resistance have decreased the success rate of standard treatment methods that use proton pump inhibitors and other eradication protocols. The plant-based compounds provide immunomodulatory properties together with gastro-protective benefits which will help improve treatment results while reducing the risks that come with antibiotic resistance. Phytochemicals from medicinal plants have developed into effective natural treatments against H. pylori because they contain various mechanisms to combat the bacteria. To achieve a review study, academic databases such as PubMed, Web of Science, Scopus, and Google Scholar were searched to cover all the available literature. The anti-H. pylori activity of compounds from Curcuma longa, Zingiber officinale, Allium sativum, and Camellia sinensis stems from their ability to block bacterial attachment while they impede biofilm development and decrease the production of pathogenic factors and their effects on host immune systems. The overview presents scientific evidence which shows that phytochemicals have therapeutic value because they serve as natural treatments that help fight antibiotic resistance while improving H. pylori treatment methods.
(© 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Competing Interests: Declarations. Competing interests: The authors declare no competing interests. Consent to Participate: All authors are equally participated in prepration of this article. Consent for Publication: All authors are agree and have full support for publication of this study. Ethical Approval: Not required. AI Declaration: The authors declared that they use AI and Chat GPT for the improvement of illustrations, English language and grammar used in this manuscript.
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Substance Nomenclature: 0 (Phytochemicals)
0 (Anti-Bacterial Agents)
Entry Date(s): Date Created: 20260723 Date Completed: 20260723 Latest Revision: 20260723
Update Code: 20260724
DOI: 10.1007/s00284-026-05078-8
PMID: 42493637
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1432-0991
DOI:10.1007/s00284-026-05078-8