Academic Journal
An injectable thiolated alginate/oxidized dextran hydrogel with curcumin-copper nanoparticles for corneal neovascularization after alkali burn.
| Τίτλος: | An injectable thiolated alginate/oxidized dextran hydrogel with curcumin-copper nanoparticles for corneal neovascularization after alkali burn. |
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| Συγγραφείς: | Bei Z; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Ye L; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China; Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Optometry and Vision Sciences, West China Hospital, Sichuan University, Chengdu, 610041, China., Liang S; Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China; Breast center, West China Hospital, Sichuan University, Chengdu, 610041, China., Tong Q; Department of Cardiovascular Surgery, West China Hospital, Med-X Center for Materials, Sichuan University, Chengdu, 610041, China., Li X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Li J; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Yu X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Wei Y; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Liang X; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Yang T; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China., Yang Y; Research Laboratory of Plastic and Burns Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China., Liu L; Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, 610041, China; Laboratory of Optometry and Vision Sciences, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: b.q15651@hotmail.com., Qian Z; Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. Electronic address: anderson-qian@163.com. |
| Πηγή: | Carbohydrate polymers [Carbohydr Polym] 2026 Sep 15; Vol. 388, pp. 125565. Date of Electronic Publication: 2026 Jun 17. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE |
| Imprint Name(s): | Publication: <1992-> : Barking : Elsevier Applied Science Publishers Original Publication: London [Eng.] : Applied Science Publishers, c1981- |
| Ιατρικοί όροι (MeSH): | Curcumin*/chemistry , Curcumin*/administration & dosage , Curcumin*/pharmacology , Alginates*/chemistry , Dextrans*/chemistry , Corneal Neovascularization*/drug therapy , Corneal Neovascularization*/chemically induced , Corneal Neovascularization*/pathology , Burns, Chemical*/drug therapy , Hydrogels*/chemistry , Hydrogels*/administration & dosage , Copper*/chemistry , Copper*/administration & dosage , Metal Nanoparticles*/chemistry , Metal Nanoparticles*/administration & dosage, Oxidative Stress/drug effects ; Antioxidants/chemistry ; Antioxidants/administration & dosage ; Sulfhydryl Compounds/chemistry ; Nanoparticles/chemistry ; Animals ; Rats ; Rats, Sprague-Dawley ; Male ; Drug Liberation |
| Περίληψη: | Corneal neovascularization (CoNV) is a major cause of visual impairment and presents significant challenges in corneal transplantation. Current treatments are limited by side effects, poor bioavailability, and the need for frequent administration. Curcumin, a natural polyphenol with potent anti-inflammatory, antioxidant, and anti-angiogenic properties, shows promise for CoNV therapy but suffers from low water solubility and rapid clearance. To address these limitations, we developed an injectable self-healing hydrogel incorporating curcumin-copper nanoparticles (CurNPs) within a thiolated alginate (SH-Alg) and oxidized dextran (ODex) matrix. This hydrogel provides localized and sustained drug release, enhancing curcumin bioavailability while minimizing systemic exposure. Its self-healing property ensures mechanical stability and consistent therapeutic delivery. In an alkali burn-induced rat model of CoNV, the OS/CurNPs (ODex/SH-Alg/CurNPs) hydrogel significantly reduced oxidative stress and inhibited corneal neovascularization, demonstrating superior antioxidant and anti-angiogenic efficacy. These results highlight the potential of this hydrogel system as a minimally invasive strategy for treating CoNV and other oxidative stress-related corneal disorders. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Alkali burn; Injectable hydrogel; Oxidative stress; Oxidized dextran; Sodium alginate |
| Substance Nomenclature: | IT942ZTH98 (Curcumin) 0 (Alginates) 0 (Dextrans) 0 (Hydrogels) 789U1901C5 (Copper) 0 (Antioxidants) 0 (Sulfhydryl Compounds) |
| Entry Date(s): | Date Created: 20260723 Date Completed: 20260723 Latest Revision: 20260723 |
| Update Code: | 20260724 |
| DOI: | 10.1016/j.carbpol.2026.125565 |
| PMID: | 42493130 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-1344 |
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| DOI: | 10.1016/j.carbpol.2026.125565 |