Academic Journal
Cellular senescence and inflammageing: from mechanisms to senotherapeutic interventions.
| Τίτλος: | Cellular senescence and inflammageing: from mechanisms to senotherapeutic interventions. |
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| Συγγραφείς: | Chmielewski PP; Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, 6a Chałubińskiego Street, 50-368, Wrocław, Poland. piotr.chmielewski@umw.edu.pl. |
| Πηγή: | Biogerontology [Biogerontology] 2026 Jul 23; Vol. 27 (4). Date of Electronic Publication: 2026 Jul 23. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 100930043 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-6768 (Electronic) Linking ISSN: 13895729 NLM ISO Abbreviation: Biogerontology Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Dordrecht ; Boston : Kluwer Academic, c2000- |
| Ιατρικοί όροι (MeSH): | Cellular Senescence*/drug effects , Cellular Senescence*/physiology , Senotherapeutics*/therapeutic use , Senotherapeutics*/pharmacology , Inflammation*/pathology , Inflammation*/drug therapy , Aging*/pathology, Humans ; Animals ; Senescence-Associated Secretory Phenotype |
| Περίληψη: | Cellular senescence is a context-dependent cellular state characterised by persistent cell-cycle arrest, epigenetic remodelling, metabolic reprogramming and acquisition of a senescence-associated secretory phenotype. Transient senescence contributes to embryogenesis, tissue repair and tumour suppression, whereas persistent senescent cell populations accumulate with advancing age across multiple tissues, in part owing to declining immune-mediated clearance and intrinsic resistance to apoptosis, thereby promoting chronic systemic inflammation, tissue fibrosis, stem-cell dysfunction and propagation of secondary senescence. Experimental genetic and pharmacological evidence supports a contributory and in several contexts causal role for senescent cells in cardiovascular, metabolic, musculoskeletal, fibrotic and neurodegenerative disorders. These findings have accelerated the development of senotherapeutic strategies, including senolytics, senomorphics and immune-mediated clearance approaches, with early clinical studies showing preliminary evidence of functional benefit in idiopathic pulmonary fibrosis and diabetic kidney disease. However, clinical translation remains constrained by senescence heterogeneity, limited biomarker specificity and unresolved long-term safety concerns. Improved molecular, spatial and functional resolution of senescent states will be essential for developing biomarker-guided and tissue-specific interventions that preserve the beneficial functions of transient senescence while limiting its chronic deleterious effects. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. |
| References: | Nat Med. 2017 Jun;23(6):775-781. (PMID: 28436958) Mol Biol Cell. 2012 Jun;23(11):2066-75. (PMID: 22496421) Nat Aging. 2024 Jun;4(6):814-838. (PMID: 38627524) J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9. (PMID: 24833586) Science. 2016 Oct 28;354(6311):472-477. (PMID: 27789842) Aging Dis. 2022 Feb 1;13(1):103-128. (PMID: 35111365) Diabetes. 2015 Jul;64(7):2289-98. (PMID: 26106186) Cell Death Discov. 2025 Oct 6;11(1):431. (PMID: 41053058) Cell. 2017 Jun 1;169(6):1000-1011. (PMID: 28575665) Biochem Soc Trans. 2024 Aug 28;52(4):1661-1671. (PMID: 38940746) Lancet. 2018 Jan 27;391(10118):319-328. (PMID: 29146124) Nat Cell Biol. 2008 Jul;10(7):825-36. (PMID: 18516091) J Cell Biol. 2011 Feb 21;192(4):547-56. (PMID: 21321098) Annu Rev Pathol. 2010;5:99-118. (PMID: 20078217) Cell. 2019 Oct 31;179(4):813-827. (PMID: 31675495) Ann N Y Acad Sci. 2007 Nov;1119:97-111. (PMID: 18056959) Cell. 2013 Jun 6;153(6):1194-217. (PMID: 23746838) J Cell Biol. 2016 Nov 7;215(3):325-334. (PMID: 27799366) Aging Cell. 2010 Oct;9(5):667-84. (PMID: 20701600) Aging Cell. 2020 Apr;19(4):e13142. (PMID: 32233024) Cell Metab. 2019 Jul 2;30(1):129-142.e4. (PMID: 31155496) Exp Gerontol. 2004 May;39(5):687-99. (PMID: 15130663) Nature. 2011 Nov 02;479(7372):232-6. (PMID: 22048312) Trends Cell Biol. 2018 Jun;28(6):436-453. (PMID: 29477613) Biogerontology. 2020 Dec;21(6):773-786. (PMID: 32776262) Cell. 2023 Jan 19;186(2):243-278. (PMID: 36599349) Cell Cycle. 2008 Sep 1;7(17):2769-73. (PMID: 18728386) J Neuroinflammation. 2021 Jan 22;18(1):32. (PMID: 33482879) PLoS One. 2013 Sep 11;8(9):e74535. (PMID: 24040275) Mol Cells. 2022 Sep 30;45(9):603-609. (PMID: 36058888) Nature. 2009 Jul 16;460(7253):392-5. (PMID: 19587680) J Nanobiotechnology. 2024 Aug 24;22(1):508. (PMID: 39182069) PLoS One. 2012;7(9):e45069. (PMID: 22984612) Biogerontology. 2018 Dec;19(6):447-459. (PMID: 30054761) EBioMedicine. 2019 Sep;47:446-456. (PMID: 31542391) JACC Basic Transl Sci. 2024 Apr 08;9(4):522-534. (PMID: 38680957) J Intern Med. 2020 Nov;288(5):518-536. (PMID: 32686219) Front Cell Dev Biol. 2022 May 18;10:882211. (PMID: 35663390) Aging Cell. 2022 Jan;21(1):e13521. (PMID: 34894056) PLoS Biol. 2020 Jan 16;18(1):e3000599. (PMID: 31945054) Nat Med. 2015 Dec;21(12):1424-35. (PMID: 26646499) Mech Ageing Dev. 2007 Jan;128(1):83-91. (PMID: 17118425) Nat Rev Drug Discov. 2025 Jan;24(1):57-71. (PMID: 39548312) Cell Cycle. 2010 Jan 15;9(2):389-97. (PMID: 20046100) Oncotarget. 2017 Apr 21;8(38):64520-64533. (PMID: 28969091) Aging Cell. 2015 Aug;14(4):497-510. (PMID: 25902704) Nat Aging. 2024 Nov;4(11):1562-1581. (PMID: 39266768) Subcell Biochem. 2023;102:271-311. (PMID: 36600137) Mech Ageing Dev. 2022 Mar;202:111618. (PMID: 34990647) Exp Cell Res. 1965 Mar;37:614-36. (PMID: 14315085) J Am Coll Cardiol. 2022 Mar 1;79(8):837-847. (PMID: 35210039) Aging Cell. 2012 Apr;11(2):345-9. (PMID: 22321662) Nat Med. 2018 Aug;24(8):1246-1256. (PMID: 29988130) Nature. 2020 Jul;583(7814):127-132. (PMID: 32555459) Nature. 2009 Oct 22;461(7267):1071-8. (PMID: 19847258) Nat Med. 2019 Dec;25(12):1822-1832. (PMID: 31806905) Semin Cell Dev Biol. 2020 May;101:104-110. (PMID: 31879264) Sci Rep. 2023 Jul 28;13(1):12240. (PMID: 37507448) Biogerontology. 2026 Apr 20;27(3):. (PMID: 42008063) Cardiovasc Res. 2022 Jun 22;118(7):1713-1727. (PMID: 34142149) Int J Mol Sci. 2026 Apr 01;27(7):. (PMID: 41977388) Cell Death Dis. 2020 Oct 28;11(10):925. (PMID: 33116117) Transl Neurodegener. 2024 Feb 20;13(1):10. (PMID: 38378788) Nat Metab. 2021 Oct;3(10):1290-1301. (PMID: 34663974) Nat Med. 2016 Jan;22(1):78-83. (PMID: 26657143) Ageing Res Rev. 2024 Jan;93:102141. (PMID: 38030088) J Cell Biol. 2018 Jan 2;217(1):65-77. (PMID: 29114066) Front Cell Neurosci. 2020 Feb 11;14:16. (PMID: 32116562) Aging Cell. 2016 Jun;15(3):428-35. (PMID: 26711051) Aging Cell. 2019 Feb;18(1):e12848. (PMID: 30462359) Adv Biol (Weinh). 2024 Sep;8(9):e2400079. (PMID: 38935557) Biochim Biophys Acta Mol Basis Dis. 2019 Oct 1;1865(10):2618-2632. (PMID: 31251987) Proc Natl Acad Sci U S A. 2015 Nov 17;112(46):E6301-10. (PMID: 26578790) Wounds. 2017 Jun;29(6):168-174. (PMID: 28682291) EBioMedicine. 2018 Oct;36:18-28. (PMID: 30279143) Mech Ageing Dev. 2020 Jul;189:111263. (PMID: 32461143) N Engl J Med. 2017 Sep 21;377(12):1119-1131. (PMID: 28845751) Trends Cell Biol. 2020 Oct;30(10):777-791. (PMID: 32800659) Nat Cell Biol. 2015 Sep;17(9):1205-17. (PMID: 26280535) Exp Gerontol. 2016 Dec 15;86:97-105. (PMID: 26924669) Nat Commun. 2017 Feb 23;8:14532. (PMID: 28230051) Sci Adv. 2023 Dec 8;9(49):eadh4990. (PMID: 38064565) Sci Aging Knowledge Environ. 2005 Feb 02;2005(5):re1. (PMID: 15689603) Exp Gerontol. 2005 Oct;40(10):813-9. (PMID: 16154306) Nature. 2018 Oct;562(7728):578-582. (PMID: 30232451) Ageing Res Rev. 2024 Apr;96:102273. (PMID: 38492810) Int J Mol Sci. 2025 Sep 05;26(17):. (PMID: 40943559) J Gerontol A Biol Sci Med Sci. 2021 Oct 13;76(11):1895-1905. (PMID: 33406219) Nat Rev Mol Cell Biol. 2024 Dec;25(12):958-978. (PMID: 38654098) Mol Cell. 2010 Oct 22;40(2):179-204. (PMID: 20965415) Nat Neurosci. 2019 May;22(5):719-728. (PMID: 30936558) Nat Commun. 2017 Jun 13;8:15691. (PMID: 28608850) Nat Commun. 2025 Sep 30;16(1):8732. (PMID: 41027926) Aging Cell. 2021 Apr;20(4):e13338. (PMID: 33711211) Aging Cell. 2021 Feb;20(2):e13296. (PMID: 33470505) Dev Cell. 2014 Dec 22;31(6):722-33. (PMID: 25499914) Cell Rep. 2018 Jan 23;22(4):930-940. (PMID: 29386135) Exp Cell Res. 1976 Jun;100(1):147-52. (PMID: 1278253) Nature. 2006 Nov 30;444(7119):633-7. (PMID: 17136093) Aging Cell. 2018 Apr;17(2):. (PMID: 29392820) Exp Mol Med. 2025 Jul;57(7):1482-1491. (PMID: 40634753) Arch Toxicol. 2024 Aug;98(8):2393-2408. (PMID: 38744709) J Intern Med. 2013 May;273(5):429-36. (PMID: 23600398) Aging Cell. 2020 Dec;19(12):e13270. (PMID: 33166065) Front Cell Dev Biol. 2021 Aug 12;9:722205. (PMID: 34458273) Ageing Res Rev. 2021 Nov;71:101458. (PMID: 34500043) Cell. 2013 Nov 21;155(5):1104-18. (PMID: 24238962) FEBS J. 2023 Mar;290(5):1203-1211. (PMID: 35904466) Geroscience. 2021 Dec;43(6):2809-2833. (PMID: 34601706) Cell Metab. 2019 May 7;29(5):1061-1077.e8. (PMID: 30612898) Nat Rev Mol Cell Biol. 2021 Feb;22(2):75-95. (PMID: 33328614) Exp Cell Res. 1961 Dec;25:585-621. (PMID: 13905658) Nat Rev Mol Cell Biol. 2014 Jul;15(7):482-96. (PMID: 24954210) Am J Physiol Lung Cell Mol Physiol. 2015 Nov 15;309(10):L1124-37. (PMID: 26386121) Metab Brain Dis. 2021 Jun;36(5):815-827. (PMID: 33599945) Pharmaceuticals (Basel). 2025 Jan 25;18(2):. (PMID: 40005976) Nature. 2016 Feb 11;530(7589):184-9. (PMID: 26840489) Cancer Prev Res (Phila). 2012 Apr;5(4):536-43. (PMID: 22262811) Aging Cell. 2019 Jun;18(3):e12945. (PMID: 30920115) Biochem Res Int. 2012;2012:951574. (PMID: 22924132) Aging Dis. 2024 Jun 2;16(4):1853-1877. (PMID: 38913049) Nat Cell Biol. 2013 Aug;15(8):978-90. (PMID: 23770676) |
| Contributed Indexing: | Keywords: Biomarkers of senescence; Cellular senescence; Geroscience; Inflammageing; Senescence-associated secretory phenotype (SASP); Senolytics; Senotherapeutics |
| Substance Nomenclature: | 0 (Senotherapeutics) |
| Entry Date(s): | Date Created: 20260723 Date Completed: 20260723 Latest Revision: 20260923 |
| Update Code: | 20260923 |
| PubMed Central ID: | PMC13396041 |
| DOI: | 10.1007/s10522-026-10477-2 |
| PMID: | 42489778 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1573-6768 |
|---|---|
| DOI: | 10.1007/s10522-026-10477-2 |