Academic Journal
Προβολή σε EDS
Συνδεδεμένο Πλήρες Κείμενο

Concurrent Four-Dimensional Dynamic MRA and Perfusion Imaging Using Dual-Module Arterial Spin Labeling MRI With Stack-Of-Stars Golden-Angle Radial Acquisition.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Concurrent Four-Dimensional Dynamic MRA and Perfusion Imaging Using Dual-Module Arterial Spin Labeling MRI With Stack-Of-Stars Golden-Angle Radial Acquisition.
Συγγραφείς: Zhao T; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA., Tang J; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA., Moum SJ; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., He Y; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA., Huang Z; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA., Khan A; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Shaibani A; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Medical Imaging, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Yan L; Department of Radiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.; Department of Biomedical Engineering, Northwestern University, Evanston, Illinois, USA.
Πηγή: NMR in biomedicine [NMR Biomed] 2026 Sep; Vol. 39 (9), pp. e70359.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley Country of Publication: England NLM ID: 8915233 Publication Model: Print Cited Medium: Internet ISSN: 1099-1492 (Electronic) Linking ISSN: 09523480 NLM ISO Abbreviation: NMR Biomed Subsets: MEDLINE
Imprint Name(s): Publication: Chichester : Wiley
Original Publication: London : Heyden & Son, 1988-
Ιατρικοί όροι (MeSH): Magnetic Resonance Angiography*/methods , Imaging, Three-Dimensional*/methods , Arteries*/diagnostic imaging , Spin Labels* , Perfusion Imaging*, Brain/blood supply ; Brain/diagnostic imaging ; Cerebrovascular Circulation ; Perfusion Magnetic Resonance Imaging ; Animals ; Humans
Περίληψη: Arterial spin labeling (ASL) has been used for perfusion imaging and non-contrast enhanced dynamic MR angiography (MRA), and both have become favorable for clinical diagnosis and treatment planning of cerebrovascular diseases. Separate sequences are typically required to obtain brain vascular hemodynamics and downstream perfusion information. However, concurrent dynamic MRA and perfusion imaging within a single acquisition can provide spatially co-registered macrovascular and microvascular maps to enhance diagnostic confidence and efficiency. In this work, we developed a dual-module ASL technique to concurrently obtain four-dimensional (4D) MRA and cerebral perfusion images from a single scan. Specifically, pseudo-continuous ASL (pCASL) and pulsed ASL (PASL) modules were integrated and encoded with a 3D stack-of-stars golden-angle radial acquisition. 4D MRA and perfusion contrasts were generated through pair-wise subtractions. Sparsity-constrained image reconstruction was used in generating 4D MRA and perfusion images from different portions of radial k-space data. Both numerical simulationsL.  and in vivo experiments were performed to demonstrate technical feasibility. Both time-resolved MRA with high spatiotemporal resolution and perfusion-weighted images with good contrast were successfully obtained from a single scan using the proposed dual-module ASL technique. The performance of the proposed technique was compared against the reference 4D MRA technique in terms of vascular delineation and blood flow dynamics, and the conventional pCASL perfusion imaging with 3D GRASE for cerebral blood flow (CBF) measurement. The dual-module ASL showed comparable performance in depicting arterial blood flow dynamics and gray matter CBF quantification (p = 0.73) to the reference 4D MRA and 3D GRASE pCASL, respectively. These results indicate the feasibility of the proposed technique for concurrent 4D MRA and perfusion imaging from a single scan, which could be a potentially powerful imaging tool for the detailed characterization of dynamic blood flow patterns through the cerebrovascular structure and downstream perfusion.
(© 2026 The Author(s). NMR in Biomedicine published by John Wiley & Sons Ltd.)
References: Magn Reson Med. 2002 Jun;47(6):1202-10. (PMID: 12111967)
Top Magn Reson Imaging. 2004 Feb;15(1):10-27. (PMID: 15057170)
N Engl J Med. 2007 Jun 28;356(26):2704-12. (PMID: 17596605)
Magn Reson Med. 2000 May;43(5):682-90. (PMID: 10800033)
Eur Radiol. 2018 Nov;28(11):4871-4881. (PMID: 29737389)
Diagn Interv Imaging. 2013 Dec;94(12):1211-23. (PMID: 23850321)
NMR Biomed. 2015 Jul;28(7):767-91. (PMID: 26010775)
Magn Reson Med. 2015 Jan;73(1):102-16. (PMID: 24715426)
Magn Reson Med. 2018 Feb;79(2):867-878. (PMID: 28480537)
J Neurosci Methods. 2018 Feb 1;295:10-19. (PMID: 29196191)
NMR Biomed. 2016 Mar;29(3):264-74. (PMID: 26676386)
Magn Reson Med. 1998 Sep;40(3):383-96. (PMID: 9727941)
Magn Reson Med. 2026 Feb;95(2):787-802. (PMID: 40955094)
Magn Reson Med. 2014 Sep;72(3):707-17. (PMID: 24142845)
Magn Reson Med. 1992 Jan;23(1):37-45. (PMID: 1734182)
Magn Reson Med. 2004 Apr;51(4):661-7. (PMID: 15065237)
Top Magn Reson Imaging. 2017 Apr;26(2):83-90. (PMID: 28277457)
Magn Reson Med. 2025 Feb;93(2):615-629. (PMID: 39344291)
NMR Biomed. 2020 Aug;33(8):e4319. (PMID: 32424992)
Magn Reson Med. 2018 May;79(5):2676-2684. (PMID: 28913838)
NMR Biomed. 2016 Jun;29(6):776-86. (PMID: 27074149)
Magn Reson Med. 2023 May;89(5):1853-1870. (PMID: 36533868)
Acta Neurol Belg. 2022 Jun;122(3):763-780. (PMID: 34553337)
Radiology. 2010 Jul;256(1):270-9. (PMID: 20574100)
Magn Reson Med. 2008 Dec;60(6):1488-97. (PMID: 19025913)
J Cereb Blood Flow Metab. 2018 Sep;38(9):1391-1417. (PMID: 28816594)
Magn Reson Med. 2018 Jul;80(1):286-293. (PMID: 29193380)
Magn Reson Med. 2013 Jan;69(1):71-81. (PMID: 22378141)
Magn Reson Med. 1995 Sep;34(3):293-301. (PMID: 7500865)
Proc Natl Acad Sci U S A. 1992 Jan 1;89(1):212-6. (PMID: 1729691)
Prim Care. 2004 Mar;31(1):95-109. (PMID: 15110161)
Radiology. 2015 Jun;275(3):772-82. (PMID: 25742194)
Neuroradiology. 2004 Dec;46(12):955-72. (PMID: 15580489)
Magn Reson Med. 2024 Oct;92(4):1568-1583. (PMID: 38767321)
Front Mol Neurosci. 2018 Sep 20;11:335. (PMID: 30294259)
Magn Reson Med. 2017 Oct;78(4):1342-1351. (PMID: 27774656)
NMR Biomed. 2021 Jul;34(7):e4519. (PMID: 33939218)
J Magn Reson Imaging. 2022 Jul;56(1):45-62. (PMID: 35396897)
Magn Reson Med. 2022 Nov;88(5):2021-2042. (PMID: 35983963)
Magn Reson Med. 2019 Jan;81(1):182-194. (PMID: 30024066)
Magn Reson Imaging. 2012 Jul;30(6):869-77. (PMID: 22521994)
Curr Opin Neurol. 2009 Aug;22(4):348-55. (PMID: 19491678)
Magn Reson Med Sci. 2020 Dec 1;19(4):294-309. (PMID: 31761840)
Grant Information: R01NS118019 National Institute of Health (NIH); RF1NS139370 National Institute of Health (NIH); R01AG072490 United States AG NIA NIH HHS; RF1AG072490 National Institute of Health (NIH); R01 NS118019 United States NS NINDS NIH HHS; RF1 AG072490 United States AG NIA NIH HHS; A20201411S BrightFocus Foundation; R01 AG072490 United States AG NIA NIH HHS; RF1 NS139370 United States NS NINDS NIH HHS
Contributed Indexing: Keywords: arterial spin labeling (ASL); bSSFP; cerebral blood flow (CBF); dynamic MR angiography (MRA); golden‐angle radial; perfusion
Substance Nomenclature: 0 (Spin Labels)
Entry Date(s): Date Created: 20260723 Date Completed: 20260723 Latest Revision: 20260823
Update Code: 20260823
PubMed Central ID: PMC13392063
DOI: 10.1002/nbm.70359
PMID: 42487211
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1099-1492
DOI:10.1002/nbm.70359