Academic Journal
Prevalence, incidence and prognostic impact of GLIM-Defined malnutrition in systemic sclerosis: A longitudinal cohort study.
| Τίτλος: | Prevalence, incidence and prognostic impact of GLIM-Defined malnutrition in systemic sclerosis: A longitudinal cohort study. |
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| Συγγραφείς: | Jiang B; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore; Duke- NUS Medical School, National University of Singapore, Singapore., Saffari SE; Department of Neurology, National Neuroscience Institute, Singapore., Noviani M; Duke- NUS Medical School, National University of Singapore, Singapore; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore., Teng GG; Alexandra Hospital, Department of Medicine, Division of Rheumatology, National University Health System, Singapore., Lim XR; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore., Ng SA; Duke- NUS Medical School, National University of Singapore, Singapore; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore., Santosa A; Division of Rheumatology, Department of Medicine, National University Hospital, Singapore., Hong C; Duke- NUS Medical School, National University of Singapore, Singapore; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore., Low AH; Duke- NUS Medical School, National University of Singapore, Singapore; Department of Rheumatology and Immunology, Singapore General Hospital, Singapore. Electronic address: Andrealow@duke-nus.edu.sg., Salazar E; Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore; Duke- NUS Medical School, National University of Singapore, Singapore. Electronic address: Ennaliza.salazar@singhealth.com.sg. |
| Πηγή: | Clinical nutrition ESPEN [Clin Nutr ESPEN] 2026 Oct; Vol. 75, pp. 103606. Date of Electronic Publication: 2026 Jul 22. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101654592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4577 (Electronic) Linking ISSN: 24054577 NLM ISO Abbreviation: Clin Nutr ESPEN Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: [Oxford] : Elsevier Ltd., [2015]- |
| Ιατρικοί όροι (MeSH): | Scleroderma, Systemic*/complications , Scleroderma, Systemic*/mortality , Scleroderma, Systemic*/epidemiology , Malnutrition*/epidemiology , Malnutrition*/diagnosis , Malnutrition*/etiology , Malnutrition*/mortality, Singapore/epidemiology ; Humans ; Male ; Female ; Middle Aged ; Prevalence ; Longitudinal Studies ; Incidence ; Prognosis ; Risk Factors ; Adult ; Aged ; Proportional Hazards Models ; Nutritional Status ; Nutrition Assessment |
| Περίληψη: | Background and Aims: Malnutrition is a known complication in systemic sclerosis (SSc), yet longitudinal data using standardised diagnostic criteria in Asian populations are limited. We aimed to determine the prevalence and incidence of malnutrition, identify risk factors for its development and evaluate its association with mortality in the SSc cohort using the Global Leadership Initiative on Malnutrition (GLIM) criteria. Methods: Patients aged 18 years and above, fulfilling the 2013 American College of Rheumatology/European Alliance of Associations for Rheumatology or 1980 ACR classification criteria for SSc who were consecutively recruited into the Singapore Systemic Sclerosis Cohort (SCORE) between January 2008 and December 2020 were eligible for inclusion. Patients were included if they had at least one baseline assessment and ≥6 months of follow-up. Patients with follow-up of less than 6 months were excluded. Malnutrition was defined using the GLIM criteria. Demographics, clinical, serological, treatment and mortality data were collected. Cox proportional hazards regression was used to assess predictors of incident malnutrition and factors associated with mortality. Results: Among 341 patients with SSc, baseline malnutrition was 14.4%, with an incidence rate of 16.83 per 1000 person-years. No baseline clinical variables were significantly associated with the development of malnutrition. In contrast, increasing age [HR 1.04 (95% CI: 1.01-1.08), p = 0.005], disease duration [HR 0.99 (95% CI: 0.99-1.00), p = 0.001], and malnutrition [HR 2.76 (95% CI: 1.25-6.10), p = 0.012] were independently associated with increased mortality among patients with SSc. Conclusion: Despite a relatively low incidence, GLIM-defined malnutrition had a strong independent association with mortality in SSc. These findings are of prognostic value and support the integration of routine screening and standardized malnutrition diagnosis in SSc care in Asian populations. (Copyright © 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Conflict of interest AHLL reports a relationship with Boehringer-Ingelheim that includes consulting or advisory, funding grants, speaking and lecture fees and travel reimbursement; and a relationship with Novartis Pharmaceuticals that includes speaking and lecture fees and travel reimbursement. The other authors declare that they have no known competing financial interests or personal relationship that could influenced the work reported in this paper. |
| Contributed Indexing: | Keywords: Asia; GLIM; Malnutrition; Nutrition assessment; Scleroderma |
| Entry Date(s): | Date Created: 20260722 Date Completed: 20260923 Latest Revision: 20260923 |
| Update Code: | 20260923 |
| DOI: | 10.1016/j.clnesp.2026.103606 |
| PMID: | 42486400 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2405-4577 |
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| DOI: | 10.1016/j.clnesp.2026.103606 |