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The impact of microbial metabolites on host chromatin and epigenetic regulation.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: The impact of microbial metabolites on host chromatin and epigenetic regulation.
Συγγραφείς: Kabir T; Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA., Lawler ZK; Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA., Gates LA; Department of Biochemistry, Case Western Reserve University, Cleveland, OH, USA. lag156@case.edu.
Πηγή: Nature metabolism [Nat Metab] 2026 Aug; Vol. 8 (8), pp. 1638-1651. Date of Electronic Publication: 2026 Jul 21.
Τύπος έκδοσης: Journal Article; Review
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Imprint Name(s): Original Publication: Berlin : Springer Nature, [2019]-
Ιατρικοί όροι (MeSH): Chromatin*/metabolism , Chromatin*/genetics , Bacteria*/metabolism , Epigenesis, Genetic* , Microbiota*, Histones/metabolism ; Humans ; Protein Processing, Post-Translational ; Animals ; Histone Code
Περίληψη: The chemical diversity of histone post-translational modifications (PTMs), or histone marks, has been greatly expanded with the discovery of understudied and emerging modifications. The microbiome and microbial metabolites have been identified as crucial regulators of these novel PTMs, many of which have key roles in gene regulation. Thus, select histone marks represent a mechanism of host-microbe interaction via chromatin. This Perspective details the emerging roles of histone marks in gene regulation and host physiology. We discuss how these PTMs are regulated by microbial metabolism and the molecular mechanisms of how these microbiota-dependent histone PTMs affect host gene expression. We also highlight examples of the functional roles of these histone marks in physiology and disease, with a focus on the intestine and associated tissues. Understanding the mechanistic link between the microbiota and the host epigenome, particularly emerging histone marks, provides new avenues of how microbial metabolites influence host physiology.
(© 2026. Springer Nature Limited.)
Competing Interests: Competing interests: The authors declare no competing interests.
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Grant Information: R00GM1433550 U.S. Department of Health & Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health)
Substance Nomenclature: 0 (Chromatin)
0 (Histones)
Entry Date(s): Date Created: 20260721 Date Completed: 20260820 Latest Revision: 20260820
Update Code: 20260820
DOI: 10.1038/s42255-026-01577-x
PMID: 42481690
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2522-5812
DOI:10.1038/s42255-026-01577-x