Academic Journal
Relationship between miRNAs dysregulation and the metastatic process associated with epithelial-mesenchymal transition in oral squamous cell carcinoma: A systematic review.
| Τίτλος: | Relationship between miRNAs dysregulation and the metastatic process associated with epithelial-mesenchymal transition in oral squamous cell carcinoma: A systematic review. |
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| Συγγραφείς: | Lemos FLM; Department of Oral Pathology, School of Dentistry, Federal University of Pará, Av. Augusto Correa 01, Belém, PA, Brazil. Electronic address: leticiamalemos@gmail.com., Guimarães LHDS; Department of Oral Pathology, School of Dentistry, Federal University of Pará, Av. Augusto Correa 01, Belém, PA, Brazil. Electronic address: lena.guimaraes@ics.ufpa.br., Fagundes NCF; Mike Petryk School of Dentistry, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, 5488 Edmonton Clinic Health Academy, 11405 87 Ave NW, Edmonton, AB T6G 1C9, Canada. Electronic address: nf1@ualberta.ca., Pinheiro JJV; Department of Oral Pathology, School of Dentistry, Federal University of Pará, Av. Augusto Correa 01, Belém, PA, Brazil. Electronic address: joaopinheiro@ufpa.br., da Silva Kataoka MS; Department of Oral Pathology, School of Dentistry, Federal University of Pará, Av. Augusto Correa 01, Belém, PA, Brazil. Electronic address: skataoka@ufpa.br., Alves Júnior SM; Department of Oral Pathology, School of Dentistry, Federal University of Pará, Av. Augusto Correa 01, Belém, PA, Brazil. Electronic address: sergioalves@ufpa.br. |
| Πηγή: | Archives of oral biology [Arch Oral Biol] 2026 Oct; Vol. 190, pp. 106696. Date of Electronic Publication: 2026 Jul 15. |
| Τύπος έκδοσης: | Journal Article; Systematic Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Pergamon Press Country of Publication: England NLM ID: 0116711 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1506 (Electronic) Linking ISSN: 00039969 NLM ISO Abbreviation: Arch Oral Biol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Pergamon Press Original Publication: Oxford, New York [etc.] Pergamon Press. |
| Ιατρικοί όροι (MeSH): | MicroRNAs*/genetics , MicroRNAs*/metabolism , Epithelial-Mesenchymal Transition*/genetics , Mouth Neoplasms*/pathology , Mouth Neoplasms*/genetics , Carcinoma, Squamous Cell*/genetics , Carcinoma, Squamous Cell*/pathology, Neoplasm Metastasis/genetics ; Humans ; Gene Expression Regulation, Neoplastic ; Lymphatic Metastasis |
| Περίληψη: | Objectives: This systematic review aimed to evaluate the relationship between miRNAs dysregulation and the occurrence of the metastatic process associated with EMT in OSCC. Designing: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Searches were conducted in the PubMed, Web of Science, LILACS, Scopus, Embase, Google Scholar, and EBSCO Teses databases. No restrictions on year or language were applied. The review protocol was developed and registered in the PROSPERO database (University of York, York, United Kingdom) under registration number CRD42024531676. Results: Eighteen studies were included in this review. A total of 17 miRNAs involved in the regulatory mechanism of EMT were identified, of which five were upregulated and twelve downregulated in OSCC tissues. Furthermore, eight deregulated miRNAs showed a significant association with lymph node metastasis, and four showed a significant correlation with distant metastasis. Conclusion: Despite the complex regulatory mechanisms of these molecules, the studies included in this review highlight the potential of miRNAs as targets for diagnosis and therapy in the clinical management of OSCC. However, further studies with larger sample sizes are needed to validate these findings. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Oral Squamous Cell Carcinoma; epithelial-mesenchymal transition; microRNAs; neoplastic metastasis |
| Substance Nomenclature: | 0 (MicroRNAs) |
| Entry Date(s): | Date Created: 20260721 Date Completed: 20260812 Latest Revision: 20260812 |
| Update Code: | 20260813 |
| DOI: | 10.1016/j.archoralbio.2026.106696 |
| PMID: | 42480174 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1879-1506 |
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| DOI: | 10.1016/j.archoralbio.2026.106696 |