Λεπτομέρειες βιβλιογραφικής εγγραφής
| Τίτλος: |
Single-cell atlas of the mouse ovary reveals molecular drivers of aging and senescence during the estropausal transition. |
| Συγγραφείς: |
Wang X; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Yang J; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Jin C; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Wang X; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Contreras D; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Devos M; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032., Kane MM; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032., Rosenfeld MG; Department of Medicine, University of California San Diego, La Jolla, CA 92093., Suh Y; Department of Obstetrics and Gynecology, Columbia University Irving Medical Center, New York, NY 10032.; Department of Genetics and Development, Columbia University Irving Medical Center, New York, NY 10032. |
| Πηγή: |
Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Jul 28; Vol. 123 (30), pp. e2600323123. Date of Electronic Publication: 2026 Jul 21. |
| Τύπος έκδοσης: |
Journal Article |
| Γλώσσα: |
English |
| Στοιχεία περιοδικού: |
Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE |
| Imprint Name(s): |
Original Publication: Washington, DC : National Academy of Sciences |
| Ιατρικοί όροι (MeSH): |
Ovary*/metabolism , Ovary*/cytology , Ovary*/physiology , Cellular Senescence*/genetics , Cellular Senescence*/physiology , Aging*/genetics , Aging*/physiology , Aging*/metabolism , Estrous Cycle*/physiology, Granulosa Cells/metabolism ; Animals ; Female ; Mice ; Single-Cell Analysis ; Transcriptome ; Single-Cell Gene Expression Analysis |
| Περίληψη: |
Reproductive aging in mice leads to estropause, characterized by estrous cycle irregularity and eventual cessation, yet its underlying mechanism remains unclear. Here, we present a comprehensive single-cell atlas of mouse ovaries across precisely defined reproductive stages-from young (regular cycling) through the estropausal transition (regular vs. irregular cycling) to post-estropause (acyclic)-and of ovary-specific senescent cells defined by high senescence-associated β-galactosidase activity. We mapped transcriptomic dynamics of ovarian aging and characterized the molecular features of ovarian senescent cells. Our analyses revealed that during the estropausal transition, irregularly cycling ovaries exhibited accelerated aging and cellular senescence features compared with regularly cycling counterparts, including increased transcriptional noise, altered conserved aging pathways such as oxidative phosphorylation and proteostasis, hormone dysregulation in granulosa cells, and elevated expression of the senescence marker Cdkn1a and senescence-associated secretory phenotype factors. This atlas delineates the cellular and molecular hallmarks of mouse ovarian aging and ovary-specific senescent cells, providing a resource for understanding the mechanisms underlying the estropausal transition. |
| Competing Interests: |
Competing interests statement:The authors declare no competing interest. |
| Grant Information: |
AG069750 HHS | NIH (NIH); DK127778 AG057433 AG061521 HL150521 AG055501 AG057341 AG057433 AG057706 AG057909 AG017242 HHS | NIH (NIH); GCRLE-1320 Global Consortium for Reproductive Longevity; N/A Simons Foundation (SF); PD25221 Glenn Foundation for Medical Research (GFMR) |
| Contributed Indexing: |
Keywords: aging; cellular senescence; estropausal transition; ovary; single-cell RNA-seq |
| Entry Date(s): |
Date Created: 20260721 Date Completed: 20260721 Latest Revision: 20260731 |
| Update Code: |
20260731 |
| PubMed Central ID: |
PMC13416851 |
| DOI: |
10.1073/pnas.2600323123 |
| PMID: |
42479833 |
| Βάση Δεδομένων: |
MEDLINE |