Acute lower leg transcutaneous electrical nerve stimulation increases leg blood flow and exercise capacity in patients with peripheral arterial disease.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος:	Acute lower leg transcutaneous electrical nerve stimulation increases leg blood flow and exercise capacity in patients with peripheral arterial disease.
Συγγραφείς:	Pellinger TK; Department of Physical Therapy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA., Neighbors CB; Sentara Center for Healthcare Simulation and Immersive Learning, Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA., Hefta JC; Department of Physical Therapy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA., Luo PH; Department of Physical Therapy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA., Suarez CB; Department of Physical Therapy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA., Varlas ET; Department of Physical Therapy, University of Maryland Eastern Shore, Princess Anne, Maryland, USA., Simmons GH; Department of Medical Pharmacology & Physiology, University of Missouri, Columbia, Missouri, USA., Wong BJ; Department of Kinesiology & Health, Georgia State University, Atlanta, Georgia, USA.
Πηγή:	Experimental physiology [Exp Physiol] 2026 Oct; Vol. 111 (10), pp. 4296-4302. Date of Electronic Publication: 2026 Jul 21.
Τύπος έκδοσης:	Journal Article; Randomized Controlled Trial
Γλώσσα:	English
Στοιχεία περιοδικού:	Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 9002940 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-445X (Electronic) Linking ISSN: 09580670 NLM ISO Abbreviation: Exp Physiol Subsets: MEDLINE
Imprint Name(s):	Publication: Cambridge, Eng : Wiley-Blackwell Original Publication: Cambridge ; New York, NY, USA : Published for the Physiological Society by Cambridge University Press, c1990-
Ιατρικοί όροι (MeSH):	Exercise/physiology , Exercise Tolerance/physiology , Leg/blood supply , Leg/physiopathology , Peripheral Arterial Disease/diagnosis , Peripheral Arterial Disease/physiopathology , Peripheral Arterial Disease/therapy , Regional Blood Flow/physiology , Transcutaneous Electric Nerve Stimulation*/methods, Ankle Brachial Index/methods ; Intermittent Claudication/diagnosis ; Intermittent Claudication/physiopathology ; Intermittent Claudication/therapy ; Popliteal Artery/physiopathology ; Walking/physiology ; Aged ; Female ; Humans ; Male ; Middle Aged
Περίληψη:	We tested the hypothesis that two different durations of lower leg transcutaneous electrical nerve stimulation (TENS) increase post-TENS popliteal artery blood flow (PABF), popliteal vascular conductance (PVC), and 6-min walk distance (6MWD) in patients with peripheral artery disease (PAD). Seven subjects (5 male, 2 female) with PAD (67.9 ± 7.4 years; claudication: ankle-brachial index (ABI) <0.90) participated in three randomized treatment sessions: control or bilateral TENS (3.0 Hz burst mode, 250 µs) for either 15 or 45 min. PABF (Doppler ultrasound) was measured before and after treatment. 6MWD and time/distance to claudication onset were measured 25 min post-treatment during each session. PABF, PVC and 6MWD increased after both 15 and 45 min of TENS (P < 0.05, post-TENS vs. pre-TENS baseline/control). Our preliminary results suggest that as little as 15 min of lower leg TENS increases leg blood flow and exercise capacity in individuals with PAD. (© 2026 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.)
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Grant Information:	GR100269 Community Foundation of the Eastern Shore
Contributed Indexing:	Keywords: claudication; electric stimulation therapy; six‐minute walk test
Entry Date(s):	Date Created: 20260721 Date Completed: 20261001 Latest Revision: 20261005
Update Code:	20261006
PubMed Central ID:	PMC13394253
DOI:	10.1113/EP093618
PMID:	42479759
Βάση Δεδομένων:	MEDLINE

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ISSN:	1469-445X
DOI:	10.1113/EP093618