Academic Journal
Maternal alcohol exposure and atopic dermatitis in offspring: A scoping review protocol.
| Τίτλος: | Maternal alcohol exposure and atopic dermatitis in offspring: A scoping review protocol. |
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| Συγγραφείς: | D'Souza PR; Department of Psychiatry, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India., D'Souza PR; Department of Pediatric Nursing, Rohilkhand College of Nursing, Bareilly, Uttar Pradesh, India. |
| Πηγή: | PloS one [PLoS One] 2026 Jul 21; Vol. 21 (7), pp. e0354140. Date of Electronic Publication: 2026 Jul 21 (Print Publication: 2026). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: San Francisco, CA : Public Library of Science |
| Ιατρικοί όροι (MeSH): | Dermatitis, Atopic*/etiology , Dermatitis, Atopic*/epidemiology , Maternal Exposure*/adverse effects , Alcohol Drinking*/adverse effects , Prenatal Exposure Delayed Effects*, Humans ; Female ; Pregnancy ; Scoping Reviews as Topic ; Fetal Alcohol Spectrum Disorders |
| Περίληψη: | Maternal alcohol use is a modifiable, yet significant public health concern, causing fetal alcohol syndrome and neurodevelopmental disorders. Research has predominantly focused on the neurodevelopmental consequences of maternal alcohol consumption, but growing evidence suggests that these effects may extend to the developing immune system, potentially increasing the risk of allergic and inflammatory conditions such as atopic dermatitis in offspring, which remains underexplored. This scoping review aims to map the available literature on the association between maternal alcohol exposure (preconception and pregnancy) and atopic dermatitis in offspring, including exposure patterns, outcome measures, and hypothesized biological mechanisms. The protocol follows Joanna Briggs Institute methodology with PEO framework (Population: offspring, Exposure: maternal alcohol use, Outcome: atopic dermatitis), and has been registered prospectively on the Open Science Framework (DOI: 10.17605/OSF.IO/EWGPB). A comprehensive search of electronic databases (PubMed, Scopus, Embase, CINAHL, Web of Science) and grey literature sources will be conducted from inception through the final search date. Two independent reviewers will screen titles, abstracts and full texts, with disagreements resolved by consensus or third-reviewer arbitration. Peer-reviewed original research articles in English reporting maternal alcohol use and diagnosed atopic dermatitis in offspring will be included. Data extraction will comprise study characteristics, exposure timing and measurement, outcome diagnostic criteria and age of assessment, key findings, and reported biological mechanisms. The preliminary findings will be validated through consultation with clinical stakeholders, including experts in allergy medicine, paediatricians, dermatologists, psychiatrists and obstetricians, to maximise the review's relevance and to identify practical implications for antenatal care and paediatric dermatology. Results will be presented through narrative synthesis, following PRISMA-ScR guidelines, to identify evidence gaps and inform future research and policy. (Copyright: © 2026 D’Souza, D’Souza. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.) |
| Competing Interests: | The authors have declared that no competing interests exist. |
| Entry Date(s): | Date Created: 20260721 Date Completed: 20260721 Latest Revision: 20260726 |
| Update Code: | 20260726 |
| PubMed Central ID: | PMC13387542 |
| DOI: | 10.1371/journal.pone.0354140 |
| PMID: | 42479743 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1932-6203 |
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| DOI: | 10.1371/journal.pone.0354140 |