Academic Journal
Exopolysaccharide-mediated silver oxide nanoparticles from Bacillus cereus GV7: green synthesis, characterization, and antimicrobial, antibiofilm, antioxidant, and anticancer activities.
| Τίτλος: | Exopolysaccharide-mediated silver oxide nanoparticles from Bacillus cereus GV7: green synthesis, characterization, and antimicrobial, antibiofilm, antioxidant, and anticancer activities. |
|---|---|
| Συγγραφείς: | Maheswari P; Department of Microbiology, Ayya Nadar Janaki Ammal College, Tamil Nadu, 626 124, Sivakasi, India., Venkatesan S; Department of Microbiology, PSG College of Arts and Science, Coimbatore, 641 014, Tamil Nadu, India., Gurusamy V; Department of Microbiology, Ayya Nadar Janaki Ammal College, Tamil Nadu, 626 124, Sivakasi, India., Sakthivel V; PG and Research Department of Botany, Saraswathi Narayanan College, Madurai, 625 022, Tamil Nadu, India., Sankaralingam S; PG and Research Department of Botany, Saraswathi Narayanan College, Madurai, 625 022, Tamil Nadu, India., Narayanaswamy K; Department of Microbiology, PSG College of Arts and Science, Coimbatore, 641 014, Tamil Nadu, India. krishnaveni.n@psgcas.ac.in. |
| Πηγή: | Archives of microbiology [Arch Microbiol] 2026 Jul 21; Vol. 208 (10). Date of Electronic Publication: 2026 Jul 21. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0410427 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-072X (Electronic) Linking ISSN: 03028933 NLM ISO Abbreviation: Arch Microbiol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin, New York, Springer-Verlag. |
| Ιατρικοί όροι (MeSH): | Bacillus cereus*/metabolism , Bacillus cereus*/isolation & purification , Bacillus cereus*/chemistry , Antioxidants*/pharmacology , Antioxidants*/metabolism , Antioxidants*/chemistry , Antineoplastic Agents*/pharmacology , Antineoplastic Agents*/metabolism , Antineoplastic Agents*/chemistry , Silver Compounds*/pharmacology , Silver Compounds*/metabolism , Silver Compounds*/chemistry , Polysaccharides, Bacterial*/metabolism , Polysaccharides, Bacterial*/chemistry , Oxides*/metabolism , Oxides*/chemistry , Oxides*/pharmacology , Metal Nanoparticles*/chemistry , Anti-Infective Agents*/pharmacology , Anti-Infective Agents*/chemistry , Anti-Infective Agents*/metabolism, Biofilms/drug effects ; Geologic Sediments/microbiology ; Anti-Bacterial Agents/pharmacology ; Humans ; Microbial Sensitivity Tests ; Cell Line, Tumor ; Silver |
| Περίληψη: | Exopolysaccharide-mediated silver nanoparticles (EPS-Ag (© 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Anticancer; Antimicrobial; Antioxidant; Biosynthesis; Exopolysaccharide; Silver oxide nanoparticles |
| Substance Nomenclature: | 0 (Antioxidants) 0 (Antineoplastic Agents) 0 (Silver Compounds) 897WUN6G6T (disilver oxide) 0 (Polysaccharides, Bacterial) 0 (Oxides) 0 (Anti-Bacterial Agents) 0 (Anti-Infective Agents) 3M4G523W1G (Silver) |
| Entry Date(s): | Date Created: 20260721 Date Completed: 20260721 Latest Revision: 20260721 |
| Update Code: | 20260721 |
| DOI: | 10.1007/s00203-026-05070-7 |
| PMID: | 42479063 |
| Βάση Δεδομένων: | MEDLINE |
| FullText | Links: – Type: other Url: https://resolver.ebsco.com:443/public/rma-ftfapi/ejs/direct?AccessToken=49A0B63F0210EAA523CA&Show=Object Text: Availability: 0 CustomLinks: – Url: https://dx.doi.org/doi:10.1007/s00203-026-05070-7 Name: EDS - Springer Nature Journals (s7799221) Category: fullText Text: View record at Springer |
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| Header | DbId: cmedm DbLabel: MEDLINE An: 42479063 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Exopolysaccharide-mediated silver oxide nanoparticles from Bacillus cereus GV7: green synthesis, characterization, and antimicrobial, antibiofilm, antioxidant, and anticancer activities. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Maheswari+P%22">Maheswari P</searchLink>; Department of Microbiology, Ayya Nadar Janaki Ammal College, Tamil Nadu, 626 124, Sivakasi, India.<br /><searchLink fieldCode="AU" term="%22Venkatesan+S%22">Venkatesan S</searchLink>; Department of Microbiology, PSG College of Arts and Science, Coimbatore, 641 014, Tamil Nadu, India.<br /><searchLink fieldCode="AU" term="%22Gurusamy+V%22">Gurusamy V</searchLink>; Department of Microbiology, Ayya Nadar Janaki Ammal College, Tamil Nadu, 626 124, Sivakasi, India.<br /><searchLink fieldCode="AU" term="%22Sakthivel+V%22">Sakthivel V</searchLink>; PG and Research Department of Botany, Saraswathi Narayanan College, Madurai, 625 022, Tamil Nadu, India.<br /><searchLink fieldCode="AU" term="%22Sankaralingam+S%22">Sankaralingam S</searchLink>; PG and Research Department of Botany, Saraswathi Narayanan College, Madurai, 625 022, Tamil Nadu, India.<br /><searchLink fieldCode="AU" term="%22Narayanaswamy+K%22">Narayanaswamy K</searchLink>; Department of Microbiology, PSG College of Arts and Science, Coimbatore, 641 014, Tamil Nadu, India. krishnaveni.n@psgcas.ac.in. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%220410427%22">Archives of microbiology</searchLink> [Arch Microbiol] 2026 Jul 21; Vol. 208 (10). <i>Date of Electronic Publication: </i>2026 Jul 21. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: Language Label: Language Group: Lang Data: English – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer-Verlag%22">Springer-Verlag </searchLink><i>Country of Publication: </i>Germany <i>NLM ID: </i>0410427 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1432-072X (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2203028933%22">03028933 </searchLink><i>NLM ISO Abbreviation: </i>Arch Microbiol <i>Subsets: </i>MEDLINE – Name: PublisherInfo Label: Imprint Name(s) Group: PubInfo Data: <i>Original Publication</i>: Berlin, New York, Springer-Verlag. – Name: SubjectMESH Label: MeSH Terms Group: Su Data: <searchLink fieldCode="MM" term="%22Bacillus+cereus%22">Bacillus cereus*</searchLink>/<searchLink fieldCode="MM" term="%22Bacillus+cereus+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Bacillus+cereus%22">Bacillus cereus*</searchLink>/<searchLink fieldCode="MM" term="%22Bacillus+cereus+isolation+%26+purification%22">isolation & purification</searchLink> <br /><searchLink fieldCode="MM" term="%22Bacillus+cereus%22">Bacillus cereus*</searchLink>/<searchLink fieldCode="MM" term="%22Bacillus+cereus+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Antioxidants%22">Antioxidants*</searchLink>/<searchLink fieldCode="MM" term="%22Antioxidants+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Antioxidants%22">Antioxidants*</searchLink>/<searchLink fieldCode="MM" term="%22Antioxidants+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Antioxidants%22">Antioxidants*</searchLink>/<searchLink fieldCode="MM" term="%22Antioxidants+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Antineoplastic+Agents%22">Antineoplastic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Antineoplastic+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Antineoplastic+Agents%22">Antineoplastic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Antineoplastic+Agents+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Antineoplastic+Agents%22">Antineoplastic Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Antineoplastic+Agents+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Silver+Compounds%22">Silver Compounds*</searchLink>/<searchLink fieldCode="MM" term="%22Silver+Compounds+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Silver+Compounds%22">Silver Compounds*</searchLink>/<searchLink fieldCode="MM" term="%22Silver+Compounds+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Silver+Compounds%22">Silver Compounds*</searchLink>/<searchLink fieldCode="MM" term="%22Silver+Compounds+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Polysaccharides%2C+Bacterial%22">Polysaccharides, Bacterial*</searchLink>/<searchLink fieldCode="MM" term="%22Polysaccharides%2C+Bacterial+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Polysaccharides%2C+Bacterial%22">Polysaccharides, Bacterial*</searchLink>/<searchLink fieldCode="MM" term="%22Polysaccharides%2C+Bacterial+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Oxides%22">Oxides*</searchLink>/<searchLink fieldCode="MM" term="%22Oxides+metabolism%22">metabolism</searchLink> <br /><searchLink fieldCode="MM" term="%22Oxides%22">Oxides*</searchLink>/<searchLink fieldCode="MM" term="%22Oxides+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Oxides%22">Oxides*</searchLink>/<searchLink fieldCode="MM" term="%22Oxides+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Metal+Nanoparticles%22">Metal Nanoparticles*</searchLink>/<searchLink fieldCode="MM" term="%22Metal+Nanoparticles+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Anti-Infective+Agents%22">Anti-Infective Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Anti-Infective+Agents+pharmacology%22">pharmacology</searchLink> <br /><searchLink fieldCode="MM" term="%22Anti-Infective+Agents%22">Anti-Infective Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Anti-Infective+Agents+chemistry%22">chemistry</searchLink> <br /><searchLink fieldCode="MM" term="%22Anti-Infective+Agents%22">Anti-Infective Agents*</searchLink>/<searchLink fieldCode="MM" term="%22Anti-Infective+Agents+metabolism%22">metabolism</searchLink><br /><searchLink fieldCode="MH" term="%22Biofilms%22">Biofilms</searchLink>/<searchLink fieldCode="MH" term="%22Biofilms+drug+effects%22">drug effects</searchLink> ; <searchLink fieldCode="MH" term="%22Geologic+Sediments%22">Geologic Sediments</searchLink>/<searchLink fieldCode="MH" term="%22Geologic+Sediments+microbiology%22">microbiology</searchLink> ; <searchLink fieldCode="MH" term="%22Anti-Bacterial+Agents%22">Anti-Bacterial Agents</searchLink>/<searchLink fieldCode="MH" term="%22Anti-Bacterial+Agents+pharmacology%22">pharmacology</searchLink> ; <searchLink fieldCode="MH" term="%22Humans%22">Humans</searchLink> ; <searchLink fieldCode="MH" term="%22Microbial+Sensitivity+Tests%22">Microbial Sensitivity Tests</searchLink> ; <searchLink fieldCode="MH" term="%22Cell+Line%2C+Tumor%22">Cell Line, Tumor</searchLink> ; <searchLink fieldCode="MH" term="%22Silver%22">Silver</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Exopolysaccharide-mediated silver nanoparticles (EPS-Ag<subscript>2</subscript>ONPs) were successfully biosynthesized using purified EPS from the marine sediment Bacillus cereus GV7. Among fourteen screened isolates, GV7 demonstrated the highest EPS production (83.7 ± 0.02 µg/mL) and was selected for Nanoparticle (NP) synthesis. EPS-Ag<subscript>2</subscript>ONPs were successfully synthesized under alkaline conditions, indicated by a characteristic colour change and subsequently UV-Vis spectroscopic analysis revealed a characteristic SPR peak at 424 nm. Further characterization using FTIR, SEM, EDX, XRD and AFM analysis confirmed the successful formation of spherical, well-dispersed, crystalline cubic Ag₂ONPs. SEM analysis revealed particle sizes ranging from 20 to 70 nm, whereas AFM analysis showed an average particle height of 5.09 nm. In this synthesis, EPS served as both a reducing and stabilizing agent. To our knowledge, no previous study has reported the biogenic synthesis of Ag<subscript>2</subscript>ONP using marine sediment-associated B. cereus GV7. Furthermore, the biosynthesized EPS-Ag<subscript>2</subscript>ONPs exhibited broad-spectrum antimicrobial efficacy against pathogenic microbes, with MIC values varied between 31.25 and 500 µg/mL. Significant antibiofilm activity was observed, with a maximum inhibition up to 84.54%, demonstrating effective disruption of biofilm formation. Dose-dependent antioxidant activity was demonstrated across DPPH, ABTS, FRAP, H₂O₂ scavenging, and total antioxidant capacity assays. Cytotoxicity evaluation against MG-63 human osteosarcoma cells by MTT assay revealed an IC<subscript>50</subscript> value of 12.22 µg/mL, indicative of strong anticancer potential. These findings collectively signify EPS-Ag<subscript>2</subscript>ONPs from B. cereus GV7 as a promising multifunctional nanomaterial with potential biomedical applications.<br /> (© 2026. 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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00203-026-05070-7 Languages: – Code: eng Text: English Subjects: – SubjectFull: Biofilms drug effects Type: general – SubjectFull: Geologic Sediments microbiology Type: general – SubjectFull: Anti-Bacterial Agents pharmacology Type: general – SubjectFull: Humans Type: general – SubjectFull: Microbial Sensitivity Tests Type: general – SubjectFull: Cell Line, Tumor Type: general – SubjectFull: Silver Type: general – SubjectFull: Bacillus cereus metabolism Type: general – SubjectFull: Bacillus cereus isolation & purification Type: general – SubjectFull: Bacillus cereus chemistry Type: general – SubjectFull: Antioxidants pharmacology Type: general – SubjectFull: Antioxidants metabolism Type: general – SubjectFull: Antioxidants chemistry Type: general – SubjectFull: Antineoplastic Agents pharmacology Type: general – SubjectFull: Antineoplastic Agents metabolism Type: general – SubjectFull: Antineoplastic Agents chemistry Type: general – SubjectFull: Silver Compounds pharmacology Type: general – SubjectFull: Silver Compounds metabolism Type: general – SubjectFull: Silver Compounds chemistry Type: general – SubjectFull: Polysaccharides, Bacterial metabolism Type: general – SubjectFull: Polysaccharides, Bacterial chemistry Type: general – SubjectFull: Oxides metabolism Type: general – SubjectFull: Oxides chemistry Type: general – SubjectFull: Oxides pharmacology Type: general – SubjectFull: Metal Nanoparticles chemistry Type: general – SubjectFull: Anti-Infective Agents pharmacology Type: general – SubjectFull: Anti-Infective Agents chemistry Type: general – SubjectFull: Anti-Infective Agents metabolism Type: general Titles: – TitleFull: Exopolysaccharide-mediated silver oxide nanoparticles from Bacillus cereus GV7: green synthesis, characterization, and antimicrobial, antibiofilm, antioxidant, and anticancer activities. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Maheswari P – PersonEntity: Name: NameFull: Venkatesan S – PersonEntity: Name: NameFull: Gurusamy V – PersonEntity: Name: NameFull: Sakthivel V – PersonEntity: Name: NameFull: Sankaralingam S – PersonEntity: Name: NameFull: Narayanaswamy K IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 07 Text: 2026 Jul 21 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1432-072X Numbering: – Type: volume Value: 208 – Type: issue Value: 10 Titles: – TitleFull: Archives of microbiology Type: main |
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