Academic Journal
Evaluation of electrophysiological biomarkers in the Amazonian fish Hyphessobrycon heterorhabdus after menthol exposure.
| Τίτλος: | Evaluation of electrophysiological biomarkers in the Amazonian fish Hyphessobrycon heterorhabdus after menthol exposure. |
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| Συγγραφείς: | da Cruz do Nascimento YJ; Laboratório de Ecotoxicologia and Laboratório de Pesquisa em Monitoramento Ambiental Marinho, Universidade Federal do Pará, Belém, PA, Brazil. yurejefferson54@gmail.com.; Programa de Pós-Graduação em Farmacologia e Bioquímica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil. yurejefferson54@gmail.com., Moutinho DS; Laboratório de Ecotoxicologia and Laboratório de Pesquisa em Monitoramento Ambiental Marinho, Universidade Federal do Pará, Belém, PA, Brazil.; Programa de Pós-Graduação em Ecologia, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil., Cantanhêde-Magno S; Laboratório de Ecotoxicologia and Laboratório de Pesquisa em Monitoramento Ambiental Marinho, Universidade Federal do Pará, Belém, PA, Brazil., Hamoy M; Laboratório de Farmacologia e Toxicologia de Produtos Naturais, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil., Amado LL; Laboratório de Ecotoxicologia and Laboratório de Pesquisa em Monitoramento Ambiental Marinho, Universidade Federal do Pará, Belém, PA, Brazil.; Programa de Pós-Graduação em Farmacologia e Bioquímica, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, PA, Brazil. |
| Πηγή: | Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology [J Comp Physiol B] 2026 Aug; Vol. 196 (4), pp. 523-533. Date of Electronic Publication: 2026 Jul 20. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 8413200 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-136X (Electronic) Linking ISSN: 01741578 NLM ISO Abbreviation: J Comp Physiol B Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin ; New York : Springer-Verlag, [c1984- |
| Ιατρικοί όροι (MeSH): | Menthol*/toxicity , Characidae*/physiology , Water Pollutants, Chemical*/toxicity, Heart Rate/drug effects ; Animals ; Biomarkers ; Electromyography ; Electrocardiography |
| Περίληψη: | Electrophysiology is an emerging approach in the context of environmental toxicology, where it represents a non-invasive biomarker that has been little studied in tropical fish. In this study, we evaluated electrocardiographic (ECG) and electromyographic (EMG) responses in Hyphessobrycon heterorhabdus, a native Amazonian species considered a promising biological model for ecotoxicological studies, and Menthol was selected as the pharmacological model for methodological validation in this species. Fish were exposed to 30 mg L- 1 for three minutes and subsequently transferred to clean water to assess recovery. The ECG showed a reduction in heart rate and an increase in the wave intervals in fish exposed to menthol. The EMG recorded the occurrence of transient muscle spasms before a progressive decrease in contraction strength as anesthesia deepened. After recovery, both ECG and EMG tracings returned to baseline conditions, indicating the reversibility of menthol-induced anesthesia. Thus, electrophysiological markers in H. heterorhabdus proved to be effective tools for detecting short-term physiological changes and supports their application in studies involving environmental stressors or chemical exposures. (© 2026. The Author(s).) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no competing interests. |
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| Contributed Indexing: | Keywords: Amazon; Ecotoxicology; Natural anesthetics; Physiological parameters; Sublethal effects |
| Substance Nomenclature: | 1490-04-6 (Menthol) 0 (Biomarkers) 0 (Water Pollutants, Chemical) |
| Entry Date(s): | Date Created: 20260720 Date Completed: 20260825 Latest Revision: 20260828 |
| Update Code: | 20260828 |
| PubMed Central ID: | PMC13506553 |
| DOI: | 10.1007/s00360-026-01694-9 |
| PMID: | 42474497 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1432-136X |
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| DOI: | 10.1007/s00360-026-01694-9 |