Academic Journal
The Role of Tissue Resident Memory Cells in Immunodermatological Disorders.
| Τίτλος: | The Role of Tissue Resident Memory Cells in Immunodermatological Disorders. |
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| Συγγραφείς: | De A; Department of Dermatology, Calcutta National Medical College and Hospital, Kolkata, India., Chakraborty D; Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA., Desai S; Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.; Innovative Dermatology, Plano, Texas, USA., Göncü EK; Department of Dermatology, Bahçeşehir University School of Medicine, Istanbul, Turkey.; Charité-Universitätsmedizin Berlin, Institute of Allergology, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Allergology and Immunology, Berlin, Germany., Damodaran SS; Department of Dermatology, Mayo Clinic, Rochester, Minnesota, USA., Cherrez-Ojeda I; Respiralab Research Group, Guayaquil, Ecuador.; Espiritu Santo University (UEES), Grupo Hospitalario Clínica Kennedy Sección Delta, Guayaquil, Ecuador., Pinter A; Department of Dermatology, Venereology and Allergology, University Hospital Frankfurt, Frankfurt, Germany. |
| Πηγή: | International journal of dermatology [Int J Dermatol] 2026 Oct; Vol. 65 (10), pp. 2028-2037. Date of Electronic Publication: 2026 Jul 20. |
| Τύπος έκδοσης: | Journal Article; Review |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Blackwell Science Country of Publication: England NLM ID: 0243704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-4632 (Electronic) Linking ISSN: 00119059 NLM ISO Abbreviation: Int J Dermatol Subsets: MEDLINE |
| Imprint Name(s): | Publication: Oxford : Blackwell Science Original Publication: Philadelphia, Lippincott. |
| Ιατρικοί όροι (MeSH): | Vitiligo*/immunology , Psoriasis*/immunology , Dermatitis, Atopic*/immunology , Memory T Cells*/immunology , Skin*/immunology , Skin*/cytology , Skin*/pathology , Immunologic Memory*, CD8-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/immunology ; Humans ; Animals |
| Περίληψη: | Tissue-resident memory T cells (TRMs) are a distinct memory T-cell subset that permanently reside in tissues such as the skin. In chronic immune-mediated dermatoses, including psoriasis, atopic dermatitis, and vitiligo, TRMs are implicated in site-specific "disease memory," contributing to persistence and relapse at previously affected sites. This review synthesizes emerging concepts on TRMs in chronic inflammatory skin diseases and discusses clinical and translational implications, including TRM-targeted therapies. Original human, animal, or in vitro studies evaluating TRMs in the pathogenesis or persistence of dermatologic diseases were included. In psoriasis, CD8+ TRMs (CD69+CD103+) persisted in clinically healed skin. For atopic dermatitis, both CD4+ and CD8+ TRMs are implicated in maintaining Th2/Th22 inflammation. In vitiligo, autoreactive CD8+ TRMs at lesional margins mediate melanocyte destruction. Across dermatological diseases, TRMs share three core features: persistence in previously affected skin after clinical resolution, rapid reactivation by diverse triggers (stress, autoantigens, allergens, or cytokines) leading to site-specific recurrence, and relative resistance to conventional therapies. Together, these properties provide a unifying framework linking tissue immune memory to the chronic, relapsing nature of inflammatory skin diseases. However, the dominant TRM pathways vary by disease, reflecting differences in immune polarization and antigen specificity. Targeting TRMs represents a promising strategy for disease control and serves as a biomarker of residual disease or flare. (© 2026 the International Society of Dermatology.) |
| References: | J Allergy Clin Immunol. 2023 Dec;152(6):1520-1540. (PMID: 37562754) Genomics. 2024 Jul;116(4):110870. (PMID: 38821220) J Dermatol. 2020 May;47(5):e210-e211. (PMID: 32124480) J Invest Dermatol. 2021 Jan;141(1):182-184.e1. (PMID: 32464150) J Invest Dermatol. 2023 Jun;143(6):1097-1100.e8. (PMID: 36581094) J Clin Invest. 2021 Jan 4;131(1):. (PMID: 32931481) Eur J Immunol. 2025 Jun;55(6):e51820. (PMID: 40534582) Annu Rev Immunol. 2024 Jun;42(1):317-345. (PMID: 38941605) Nat Immunol. 2023 Aug;24(8):1308-1317. (PMID: 37365384) J Exp Med. 2021 Apr 5;218(4):. (PMID: 33755718) J Invest Dermatol. 2026 Jan;146(1):165-174.e3. (PMID: 40441294) Front Immunol. 2023 Apr 19;14:1148359. (PMID: 37153617) Chin Med J (Engl). 2025 May 20;138(10):1175-1183. (PMID: 40066785) Front Oncol. 2022 Jan 14;11:819505. (PMID: 35096624) Arthritis Rheumatol. 2021 Jul;73(7):1220-1232. (PMID: 33452865) J Immunol. 2009 May 1;182(9):5296-305. (PMID: 19380776) Clin Immunol. 2022 Dec;245:109183. (PMID: 36371067) Sci Transl Med. 2020 Nov 18;12(570):. (PMID: 33208504) J Invest Dermatol. 2025 Aug;145(8):2082-2085.e6. (PMID: 39947280) Contact Dermatitis. 2017 Apr;76(4):218-227. (PMID: 27873334) J Invest Dermatol. 2020 Jul;140(7):1442-1445.e4. (PMID: 31883960) J Eur Acad Dermatol Venereol. 2023 Oct;37(10):2016-2027. (PMID: 37262309) J Invest Dermatol. 2021 Oct;141(10):2426-2435.e5. (PMID: 33845077) Sci Immunol. 2021 Jan 22;6(55):. (PMID: 33483337) Int J Dermatol. 2025 Dec;64(12):2247-2256. (PMID: 40660423) Sci Transl Med. 2018 Jul 18;10(450):. (PMID: 30021889) J Invest Dermatol. 2020 Apr;140(4):806-815.e5. (PMID: 31518559) J Invest Dermatol. 2018 Feb;138(2):355-364. (PMID: 28927891) Allergy. 2024 Jan;79(1):52-64. (PMID: 37539746) J Invest Dermatol. 2008 May;128(5):1207-11. (PMID: 18200064) Br J Dermatol. 2019 Aug;181(2):410-412. (PMID: 30737771) J Dermatol Sci. 2019 Jul;95(1):21-27. (PMID: 31300254) Int J Dermatol. 2025 Feb;64(2):436-438. (PMID: 39090802) Allergol Int. 2025 Oct;74(4):641-643. (PMID: 40555600) Eur J Med Res. 2025 Jun 5;30(1):453. (PMID: 40474234) J Dermatol. 2023 May;50(5):710-714. (PMID: 36514908) Br J Dermatol. 2019 Jan;180(1):219-220. (PMID: 30120898) Lancet. 2021 Apr 3;397(10281):1301-1315. (PMID: 33812489) J Autoimmun. 2021 Feb;117:102574. (PMID: 33307312) Front Immunol. 2018 Nov 20;9:2692. (PMID: 30515169) Br J Dermatol. 2025 Jan 24;192(2):293-305. (PMID: 39503255) Immunity. 2014 Dec 18;41(6):886-97. (PMID: 25526304) J Invest Dermatol. 2021 Aug;141(8):1943-1953.e13. (PMID: 33610558) Front Immunol. 2020 May 19;11:775. (PMID: 32508808) J Invest Dermatol. 2020 May;140(5):1015-1025.e4. (PMID: 31715177) J Allergy Clin Immunol. 2024 Aug;154(2):355-374. (PMID: 38734386) Exp Dermatol. 2024 Jan;33(1):e14982. (PMID: 37994568) Immunol Rev. 2023 Jul;316(1):104-119. (PMID: 37144705) Clin Immunol. 2023 Nov;256:109805. (PMID: 37832861) Nat Immunol. 2013 Dec;14(12):1294-301. (PMID: 24162776) Cell Rep. 2020 Sep 1;32(9):108085. (PMID: 32877667) Clin Immunol. 2024 Sep;266:110328. (PMID: 39067676) J Immunol. 2014 Apr 1;192(7):3111-20. (PMID: 24610014) J Allergy Clin Immunol. 2020 Jun;145(6):1615-1628. (PMID: 32035984) Nature. 2010 Jul 1;466(7302):113-7. (PMID: 20596022) J Invest Dermatol. 2019 Apr;139(4):769-778. (PMID: 30423329) J Invest Dermatol. 2021 Jul;141(7):1707-1718.e9. (PMID: 33524368) |
| Contributed Indexing: | Keywords: alopecia areata; atopic dermatitis; psoriasis; skin disorders; tissue resident memory cells; vitiligo |
| Entry Date(s): | Date Created: 20260720 Date Completed: 20260911 Latest Revision: 20260913 |
| Update Code: | 20260913 |
| PubMed Central ID: | PMC13569271 |
| DOI: | 10.1111/ijd.70594 |
| PMID: | 42473984 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1365-4632 |
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| DOI: | 10.1111/ijd.70594 |