Academic Journal
Tyrosinase inhibition mechanism of kojic acid-phenylpiperazine derivatives and their anti-browning effect on fresh-cut apples.
| Τίτλος: | Tyrosinase inhibition mechanism of kojic acid-phenylpiperazine derivatives and their anti-browning effect on fresh-cut apples. |
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| Συγγραφείς: | Zhao Y; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, 561113, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guian New Area, 561113, China., Zhang J; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, 561113, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guian New Area, 561113, China., Huang Y; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, 561113, China; School of Pharmaceutical Sciences, Guizhou Medical University, Guian New Area, 561113, China., Peng Z; Clinical Trails Center, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China. Electronic address: pengzhiyun1986@163.com., Wang G; State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine, Engineering Research Center for the Development and Application of Ethnic Medicine and TCM (Ministry of Education), Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and TCM, Guizhou Medical University, Guian New Area, 561113, China. Electronic address: wanggch123@163.com. |
| Πηγή: | Food chemistry [Food Chem] 2026 Oct 01; Vol. 525 (Pt 2), pp. 150421. Date of Electronic Publication: 2026 Jul 14. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 7702639 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7072 (Electronic) Linking ISSN: 03088146 NLM ISO Abbreviation: Food Chem Subsets: MEDLINE |
| Imprint Name(s): | Publication: Barking : Elsevier Applied Science Publishers Original Publication: Barking, Eng., Applied Science Publishers. |
| Ιατρικοί όροι (MeSH): | Monophenol Monooxygenase*/antagonists & inhibitors , Monophenol Monooxygenase*/chemistry , Enzyme Inhibitors*/chemistry , Enzyme Inhibitors*/pharmacology , Piperazines*/chemistry , Piperazines*/pharmacology , Pyrones*/chemistry , Pyrones*/pharmacology , Malus*/chemistry , Malus*/enzymology , Fungal Proteins*/chemistry , Fungal Proteins*/antagonists & inhibitors , Plant Proteins*/chemistry , Plant Proteins*/antagonists & inhibitors, Fruit/chemistry ; Fruit/enzymology ; Maillard Reaction/drug effects ; Food Preservation/methods ; Humans ; Animals ; Mice ; Kinetics ; Molecular Docking Simulation ; Molecular Structure |
| Περίληψη: | Tyrosinase, a rate-limiting enzyme in the enzymatic browning reaction, is a key target for fresh food preservation. Fifteen novel kojic acid-phenylpiperazine derivatives (4a-4o) were synthesized and structurally characterized by 1H NMR, 13C NMR and HRMS. In vitro assays showed most derivatives had stronger tyrosinase inhibitory activity than kojic acid (IC (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Anti-browning agent; Kojic acid; Piperazine; Tyrosinase inhibitor |
| Substance Nomenclature: | EC 1.14.18.1 (Monophenol Monooxygenase) 6K23F1TT52 (kojic acid) 0 (Enzyme Inhibitors) 0 (Piperazines) 0 (Pyrones) J9225CBI7D (phenylpiperazine) 0 (Fungal Proteins) 0 (Plant Proteins) |
| Entry Date(s): | Date Created: 20260717 Date Completed: 20260906 Latest Revision: 20260906 |
| Update Code: | 20260906 |
| DOI: | 10.1016/j.foodchem.2026.150421 |
| PMID: | 42468424 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-7072 |
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| DOI: | 10.1016/j.foodchem.2026.150421 |