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Patient characteristics, vital signs and tcpCO2 dynamics significantly influence tcpCO2 accuracy in extremely preterm infants: an observational study.

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Τίτλος: Patient characteristics, vital signs and tcpCO2 dynamics significantly influence tcpCO2 accuracy in extremely preterm infants: an observational study.
Συγγραφείς: Olivier L; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany., Lauterbach Oprea C; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Stollenwerk A; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Pfannschmidt V; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Orlikowsky T; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany., Schoberer M; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany.
Πηγή: Frontiers in pediatrics [Front Pediatr] 2026 Jul 02; Vol. 14, pp. 1878177. Date of Electronic Publication: 2026 Jul 02 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE
Imprint Name(s): Original Publication: Lausanne : Frontiers Media SA, [2013]-
Περίληψη: Purpose: The estimation of the partial pressure of carbon dioxide (pCO2) is of interest in extremely premature infants. Neonatal intensive care units use transcutaneous pCO2 monitoring (tcpCO2) as a trend parameter and continuous estimate of pCO2. Our objective was to identify candidate influence factors on the accuracy of tcpCO2 in extremely premature infants in their first week of life.
Methods: In a retrospective cohort study, linear mixed-effects models were used to analyze the influence of patient characteristics, vital signs and tcpCO2 dynamics on the difference of tcpCO2 and capillary pCO2 as reference (ΔpCO2). Candidate parameters identified in univariate analyses were incorporated into multivariable models to confirm their effect on ΔpCO2.
Results: 500 measurements from 29 extremely preterm infants were analyzed. Postnatal age, mean fraction of inspired oxygen, tcpCO2, capillary pCO2, last tcpCO2 and last ΔpCO2 were positively associated with ΔpCO2, while gestational age and hemoglobin were negatively associated with ΔpCO2.
Conclusion: These candidate parameters may be used to enhance the non-invasive estimation of pCO2 from tcpCO2 in the future.
Trial Registration: German Clinical Trials Register (DRKS00033228, first registered 29 August 2024, https://drks.de/search/en/trial/DRKS00033228/details).
(© 2026 Olivier, Lauterbach Oprea, Stollenwerk, Pfannschmidt, Orlikowsky and Schoberer.)
Competing Interests: The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Contributed Indexing: Keywords: extremely premature infant; neonatal intensive care unit; neonates; tcPCO2; transcutaneous CO2
Entry Date(s): Date Created: 20260717 Date Completed: 20260717 Latest Revision: 20260717
Update Code: 20260718
PubMed Central ID: PMC13372894
DOI: 10.3389/fped.2026.1878177
PMID: 42465207
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2296-2360
DOI:10.3389/fped.2026.1878177