Academic Journal
Προβολή σε EDS

Patient characteristics, vital signs and tcpCO2 dynamics significantly influence tcpCO2 accuracy in extremely preterm infants: an observational study.

Λεπτομέρειες βιβλιογραφικής εγγραφής
Τίτλος: Patient characteristics, vital signs and tcpCO2 dynamics significantly influence tcpCO2 accuracy in extremely preterm infants: an observational study.
Συγγραφείς: Olivier L; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany., Lauterbach Oprea C; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Stollenwerk A; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Pfannschmidt V; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Orlikowsky T; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany., Schoberer M; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany.
Πηγή: Frontiers in pediatrics [Front Pediatr] 2026 Jul 02; Vol. 14, pp. 1878177. Date of Electronic Publication: 2026 Jul 02 (Print Publication: 2026).
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101615492 Publication Model: eCollection Cited Medium: Print ISSN: 2296-2360 (Print) Linking ISSN: 22962360 NLM ISO Abbreviation: Front Pediatr Subsets: PubMed not MEDLINE
Imprint Name(s): Original Publication: Lausanne : Frontiers Media SA, [2013]-
Περίληψη: Purpose: The estimation of the partial pressure of carbon dioxide (pCO2) is of interest in extremely premature infants. Neonatal intensive care units use transcutaneous pCO2 monitoring (tcpCO2) as a trend parameter and continuous estimate of pCO2. Our objective was to identify candidate influence factors on the accuracy of tcpCO2 in extremely premature infants in their first week of life.
Methods: In a retrospective cohort study, linear mixed-effects models were used to analyze the influence of patient characteristics, vital signs and tcpCO2 dynamics on the difference of tcpCO2 and capillary pCO2 as reference (ΔpCO2). Candidate parameters identified in univariate analyses were incorporated into multivariable models to confirm their effect on ΔpCO2.
Results: 500 measurements from 29 extremely preterm infants were analyzed. Postnatal age, mean fraction of inspired oxygen, tcpCO2, capillary pCO2, last tcpCO2 and last ΔpCO2 were positively associated with ΔpCO2, while gestational age and hemoglobin were negatively associated with ΔpCO2.
Conclusion: These candidate parameters may be used to enhance the non-invasive estimation of pCO2 from tcpCO2 in the future.
Trial Registration: German Clinical Trials Register (DRKS00033228, first registered 29 August 2024, https://drks.de/search/en/trial/DRKS00033228/details).
(© 2026 Olivier, Lauterbach Oprea, Stollenwerk, Pfannschmidt, Orlikowsky and Schoberer.)
Competing Interests: The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References: Neonatology. 2023;120(3):308-316. (PMID: 36996768)
Pediatrics. 2007 Feb;119(2):299-305. (PMID: 17272619)
J Clin Med. 2023 Sep 04;12(17):. (PMID: 37685823)
BMC Pediatr. 2005 Aug 10;5:30. (PMID: 16092957)
Ann Intern Med. 2007 Oct 16;147(8):573-7. (PMID: 17938396)
Pediatrics. 2010 Sep;126(3):443-56. (PMID: 20732945)
Crit Care Med. 2017 Aug;45(8):1317-1324. (PMID: 28538439)
J Invest Dermatol. 1998 Aug;111(2):320-6. (PMID: 9699737)
Am J Perinatol. 2014 May;31(5):435-40. (PMID: 23918520)
Front Biosci. 2008 Jan 01;13:1340-51. (PMID: 17981634)
Respir Care. 2016 Jan;61(1):90-7. (PMID: 26508771)
Adv Exp Med Biol. 1987;220:115-20. (PMID: 3118653)
J Perinatol. 2005 Jan;25(1):26-9. (PMID: 15496874)
Crit Care Med. 1997 Nov;25(11):1904-8. (PMID: 9366777)
Crit Care Res Pract. 2016;2016:8041967. (PMID: 27375901)
Acta Obstet Gynecol Scand. 1977;56(3):247-53. (PMID: 560099)
Semin Fetal Neonatal Med. 2009 Feb;14(1):21-7. (PMID: 18974027)
Intensive Care Med. 2017 Jan;43(1):91-93. (PMID: 26868920)
Am J Perinatol. 2017 Apr;34(5):480-485. (PMID: 27673754)
Front Pediatr. 2023 Jul 07;11:1213243. (PMID: 37484764)
Pediatrics. 2019 Feb;143(2):. (PMID: 30705140)
Masui. 2012 Jun;61(6):638-42. (PMID: 22746032)
Pediatrics. 2016 Jul;138(1):. (PMID: 27302979)
J Neural Transm (Vienna). 2020 Jan;127(1):1-8. (PMID: 31863172)
Front Pediatr. 2026 Mar 31;14:1794358. (PMID: 41988149)
J Physiol. 2011 Jun 15;589(Pt 12):3039-48. (PMID: 21521758)
J Perinatol. 2021 Feb;41(2):324-329. (PMID: 33033388)
Pediatrics. 2006 Oct;118(4):1654-9. (PMID: 17015558)
J Matern Fetal Neonatal Med. 2021 Aug;34(16):2660-2665. (PMID: 31588840)
Bull World Health Organ. 2001;79(4):373-4. (PMID: 11357217)
Respir Care. 2018 Jul;63(7):900-906. (PMID: 29717098)
Chest. 1991 May;99(5):1211-5. (PMID: 2019180)
Lancet. 2023 Oct 7;402(10409):1261-1271. (PMID: 37805217)
Pediatr Res. 2025 Dec 17;:. (PMID: 41407889)
Thorax. 2019 Feb;74(2):157-163. (PMID: 30209079)
Acta Paediatr. 2011 May;100(5):676-9. (PMID: 21244487)
Antioxidants (Basel). 2021 Sep 18;10(9):. (PMID: 34573122)
N Engl J Med. 2017 Feb 16;376(7):617-628. (PMID: 28199816)
Anesth Analg. 2007 Dec;105(6 Suppl):S48-S52. (PMID: 18048898)
Acute Crit Care. 2025 May;40(2):153-159. (PMID: 40494592)
Semin Neonatol. 2000 Nov;5(4):273-80. (PMID: 11032710)
Clin Microbiol Rev. 2014 Jan;27(1):21-47. (PMID: 24396135)
Early Hum Dev. 2009 Sep;85(9):549-55. (PMID: 19520525)
Sci Rep. 2022 Jun 14;12(1):9853. (PMID: 35701446)
JAMA. 2022 Jan 18;327(3):248-263. (PMID: 35040888)
Contributed Indexing: Keywords: extremely premature infant; neonatal intensive care unit; neonates; tcPCO2; transcutaneous CO2
Entry Date(s): Date Created: 20260717 Date Completed: 20260717 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13372894
DOI: 10.3389/fped.2026.1878177
PMID: 42465207
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:2296-2360
DOI:10.3389/fped.2026.1878177