Academic Journal
A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory.
| Τίτλος: | A TREK-1/AQP4/TRPA1/BDNF Signaling Axis Is Associated With Astrocytic Volume Transients, Synaptic Plasticity, and Spatial Memory. |
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| Συγγραφείς: | Drew VJ; Center for Memory and Glioscience, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Woo J; Department of Neuroscience, Division of Bio-Medical Science & Technology, Korea University of Science and Technology (UST), Seoul, Republic of Korea., Lee JM; Center for Memory and Glioscience, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Koh W; Center for Memory and Glioscience, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Won J; Center for Memory and Glioscience, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Lee JH; Center for Memory and Glioscience, Institute for Basic Science (IBS), Daejeon, Republic of Korea., Lee CJ; Center for Memory and Glioscience, Institute for Basic Science (IBS), Daejeon, Republic of Korea. |
| Πηγή: | Glia [Glia] 2026 Sep; Vol. 74 (9), pp. e70195. |
| Τύπος έκδοσης: | Journal Article; Research Support, Non-U.S. Gov't |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8806785 Publication Model: Print Cited Medium: Internet ISSN: 1098-1136 (Electronic) Linking ISSN: 08941491 NLM ISO Abbreviation: Glia Subsets: MEDLINE |
| Imprint Name(s): | Publication: New York, NY : Wiley-Liss Original Publication: New York : Alan R. Liss, Inc., c1988- |
| Ιατρικοί όροι (MeSH): | Astrocytes*/metabolism , Astrocytes*/drug effects , Brain-Derived Neurotrophic Factor*/metabolism , Neuronal Plasticity*/physiology , Neuronal Plasticity*/drug effects , TRPA1 Cation Channel*/metabolism , Potassium Channels, Tandem Pore Domain*/metabolism , Spatial Memory*/physiology , Spatial Memory*/drug effects , Aquaporin 4*/metabolism, Signal Transduction/physiology ; Hippocampus/metabolism ; Hippocampus/cytology ; Animals ; Male ; Cell Size ; Rats, Sprague-Dawley |
| Περίληψη: | Astrocytes, known for their support roles, are emerging as active participants in synaptic plasticity and cognitive functions. Astrocytes actively regulate synaptic plasticity and memory through dynamic volume transients. Our previous research identified several key molecules, including TREK-1, TRPA1, and Best1 ion channels, as well as the gliotransmitter BDNF, as critical components of astrocytic volume transients. However, the precise mechanisms by which these volume transients influence synaptic plasticity and memory remain poorly understood. In this study, we investigate the roles of TREK-1 and TRPA1 in astrocytic volume dynamics and their downstream effects. Our findings, based on intrinsic optical signal imaging, electrophysiology, and behavioral assays, support a model in which neuronal stimulation induces astrocytic swelling, initiated by K+ uptake through TREK-1 channels and regulated by Ca2+ influx via TRPA1 channels. This swelling is closely associated with short- and long-term potentiation (LTP), and exogenous BDNF restores LTP under conditions of calcium sequestration during astrocytic calcium clamping experiments. Disruption of ion channels associated with astrocytic volume transients leads to significant impairments in spatial memory, as demonstrated by deficits in object-place recognition and passive avoidance tasks. Moreover, these channels contribute to the regulation of synaptic plasticity. These findings implicate astrocytic volume transients and BDNF as pivotal modulators of synaptic plasticity and memory, as well as potential therapeutic targets for addressing memory dysfunctions. (© 2026 The Author(s). GLIA published by Wiley Periodicals LLC.) |
| References: | Sci Rep. 2016 Sep 19;6:33694. (PMID: 27640722) Neuroscience. 2016 May 26;323:43-61. (PMID: 25862587) Exp Neurobiol. 2019 Feb;28(1):30-42. (PMID: 30853822) Neuron. 2020 Nov 25;108(4):691-706.e10. (PMID: 32905785) Neuron. 2016 Nov 23;92(4):873-887. (PMID: 27746130) J Physiol. 2020 Oct;598(20):4555-4572. (PMID: 32706443) Neuron. 2003 Sep 11;39(6):975-90. (PMID: 12971897) Biol Psychiatry. 2022 Apr 15;91(8):740-752. (PMID: 34952697) J Neurophysiol. 2008 Dec;100(6):3264-74. (PMID: 18842955) J Neurosci. 1991 May;11(5):1458-69. (PMID: 1851222) Glia. 2002 Feb;37(2):114-23. (PMID: 11754210) Science. 2010 Nov 5;330(6005):790-6. (PMID: 20929730) Mol Psychiatry. 2018 Apr;23(4):1021-1030. (PMID: 29565042) Nature. 2016 Oct 6;538(7623):99-103. (PMID: 27680698) Prog Neurobiol. 1996 Jun;49(3):185-214. (PMID: 8878303) Nature. 2021 Dec;600(7890):686-689. (PMID: 34819666) Vitam Horm. 2017;104:153-195. (PMID: 28215294) Proc Natl Acad Sci U S A. 2004 Jul 13;101(28):10380-5. (PMID: 15240889) Cell. 2012 Sep 28;151(1):25-40. (PMID: 23021213) Neuron. 1992 Dec;9(6):1081-8. (PMID: 1463608) Exp Neurobiol. 2018 Jun;27(3):155-170. (PMID: 30022867) Nature. 2010 Jan 14;463(7278):232-6. (PMID: 20075918) Mol Med. 2021 Oct 15;27(1):127. (PMID: 34654365) Mol Psychiatry. 2022 Feb;27(2):873-885. (PMID: 34642458) J Neurosci. 2008 Jan 2;28(1):264-78. (PMID: 18171944) Dev Biol. 2002 Apr 15;244(2):305-18. (PMID: 11944939) J Neurosci. 2013 Jun 12;33(24):10143-53. (PMID: 23761909) Cell Rep. 2018 Aug 7;24(6):1550-1561. (PMID: 30089265) Front Cell Neurosci. 2018 Sep 27;12:319. (PMID: 30319359) Neuropsychopharmacol Rep. 2021 Dec;41(4):485-495. (PMID: 34529365) Neuron. 1996 Jun;16(6):1137-45. (PMID: 8663990) Front Integr Neurosci. 2016 Feb 24;10:8. (PMID: 26941623) Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8856-60. (PMID: 7568031) Curr Opin Neurobiol. 2023 Jun;80:102706. (PMID: 36931116) J Lipid Atheroscler. 2024 May;13(2):122-138. (PMID: 38826183) Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr;387(4):303-12. (PMID: 24402080) Neural Regen Res. 2022 Apr;17(4):705-716. (PMID: 34472455) |
| Grant Information: | IBS-R001-D2 |
| Contributed Indexing: | Keywords: AQP4; BDNF; TREK‐1; TRPA1; astrocytic volume transient; spatial memory; synaptic plasticity |
| Substance Nomenclature: | 0 (Brain-Derived Neurotrophic Factor) 0 (TRPA1 Cation Channel) 0 (Potassium Channels, Tandem Pore Domain) 0 (potassium channel protein TREK-1) 0 (Aquaporin 4) 0 (Trpa1 protein, rat) |
| Entry Date(s): | Date Created: 20260716 Date Completed: 20260716 Latest Revision: 20260813 |
| Update Code: | 20260814 |
| PubMed Central ID: | PMC13373336 |
| DOI: | 10.1002/glia.70195 |
| PMID: | 42458823 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1098-1136 |
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| DOI: | 10.1002/glia.70195 |