Academic Journal
Discovery of new α-pyrone derivative with α-glucosidase inhibitory activity from the fungus Acremonium persicinum.
| Title: | Discovery of new α-pyrone derivative with α-glucosidase inhibitory activity from the fungus Acremonium persicinum. |
|---|---|
| Authors: | Tu Y; State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China., Zhang B; State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.; University of Chinese Academy of Sciences, Beijing, PR China., Bao M; State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.; University of Chinese Academy of Sciences, Beijing, PR China., Ji M; State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China.; University of Chinese Academy of Sciences, Beijing, PR China., Liu L; State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology, Chinese Academy of Sciences, Beijing, PR China. liul@im.ac.cn.; University of Chinese Academy of Sciences, Beijing, PR China. liul@im.ac.cn. |
| Source: | The Journal of antibiotics [J Antibiot (Tokyo)] 2026 Oct; Vol. 79 (10), pp. 621-625. Date of Electronic Publication: 2026 Jul 15. |
| Publication Type: | Journal Article |
| Language: | English |
| Journal Info: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1469 (Electronic) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2009- : London : Nature Publishing Group Original Publication: Tokyo, Japan Antibiotics Research Assn. |
| MeSH Terms: | Acremonium*/chemistry , Acremonium*/metabolism , Glycoside Hydrolase Inhibitors*/pharmacology , Glycoside Hydrolase Inhibitors*/chemistry , Glycoside Hydrolase Inhibitors*/isolation & purification , Pyrones*/pharmacology , Pyrones*/chemistry , Pyrones*/isolation & purification, alpha-Glucosidases/metabolism ; Magnetic Resonance Spectroscopy ; Spectrometry, Mass, Electrospray Ionization ; Molecular Docking Simulation ; Molecular Structure ; Kinetics |
| Abstract: | One new α-pyrone derivative, acremopyrone A (1) was isolated from the soil-derived fungus Acremonium persicinum 3.2858. The structure of 1 was elucidated by comprehensive spectroscopic analysis including nuclear magnetic resonance (NMR) and high-resolution electrospray ionization mass spectrometry (HRESIMS). Compound 1 showed significant inhibitory activity against α-glucosidase. Enzyme kinetic analysis revealed a mixed-type mode of inhibition, which was further supported by molecular docking studies. (© 2026. The Author(s), under exclusive licence to the Japan Antibiotics Research Association.) |
| Competing Interests: | Compliance with ethical standards. Conflict of interest: The authors declare no competing interests. |
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| Grant Information: | 32022002 National Natural Science Foundation of China (National Science Foundation of China) |
| Substance Nomenclature: | 0 (Glycoside Hydrolase Inhibitors) 0 (Pyrones) EC 3.2.1.20 (alpha-Glucosidases) |
| Entry Date(s): | Date Created: 20260714 Date Completed: 20260927 Latest Revision: 20261008 |
| Update Code: | 20261008 |
| DOI: | 10.1038/s41429-026-00946-8 |
| PMID: | 42449146 |
| Database: | MEDLINE |
| ISSN: | 1881-1469 |
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| DOI: | 10.1038/s41429-026-00946-8 |