Academic Journal
Fetal myogenesis chromatin state and CpG from the open alliance markers and their intersection with adult muscle and gastrointestinal genetics.
| Τίτλος: | Fetal myogenesis chromatin state and CpG from the open alliance markers and their intersection with adult muscle and gastrointestinal genetics. |
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| Συγγραφείς: | Cheng X; Department of Stomatology, Hangzhou Linping District Women & Children Hospital, 359 Renmin Avenue, Linping District, Hangzhou 31100, China.; Outpatient Medical Center, Linping Branch, Women's Hospital, School of Medicine, Zhejiang University, 359 Renmin Avenue, Linping District, Hangzhou 31100, China., Wu C; Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, Zhejiang University, N1 Shangcheng Avenue, Yiwu 32200, China., Yang X; Department of Obstetrics, the Fourth Affiliated Hospital of School of Medicine, Zhejiang University, N1 Shangcheng Avenue, Yiwu 32200, China., Liu R; Center for Reproductive Medicine, the Fourth Affiliated Hospital of School of Medicine, Zhejiang University, N1 Shangcheng Avenue, Yiwu 32200, China. |
| Πηγή: | Human molecular genetics [Hum Mol Genet] 2026 Jun 06; Vol. 35 (14). |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Oxford, England ; New York : IRL Press at Oxford University Press, c1992- |
| Ιατρικοί όροι (MeSH): | Muscle Development*/genetics , Chromatin*/genetics , Chromatin*/metabolism , CpG Islands*/genetics , Gastrointestinal Tract*/metabolism, DNA Methylation/genetics ; Epigenesis, Genetic/genetics ; Quantitative Trait Loci/genetics ; Gene Regulatory Networks/genetics ; Fetus/metabolism ; Muscle, Skeletal/metabolism ; Humans ; Female ; Genome-Wide Association Study ; Gene Expression Regulation, Developmental ; Adult |
| Περίληψη: | Background: Epigenetic inheritance links fetal chromatin organization and CpG methylation to lifelong tissue phenotypes. We tested the Fetal Chromatin-CpG Developmental Blueprint (FCCD-B) model, proposing that fetal chromatin states shaped by maternal nutrient and transcription factor networks establish regulatory programs preserved in adult traits. Methods: We integrated 21 970 fetal single-cell transcriptomes with chromatin accessibility data, including 130 myogenic cells. Adult GWAS datasets included 1614 appendicular lean mass (ALM) loci and 445 grip strength loci. Fine-mapping, colocalization, and gene regulatory networks were inferred using GRNBoost2, Enformer, and Basenji, alongside virtual-cell simulations of nutrient and stress perturbations. Results: ALM and grip strength showed strong genetic correlation (rg = 0.49; Z = 26). Fine-mapping identified 1355 high-confidence ALM loci (median PIP = 0.91). A total of 2935 shared GWAS-eQTL variants overlapped fetal chromatin, with 70-88% accessibility preserved in endothelial and cardiomyocyte lineages. A SMAD3-centered TGF-β network (50 targets) was identified. Simulations showed that vitamin D, folate, and oxidative stress increased myofibril index (+0.141), epithelial regeneration (+0.035), and combined effects (+0.147). Conclusion: Persistent fetal chromatin and CpG architectures encode regulatory programs linking maternal environment to adult phenotypes, supporting the FCCD-B model as a predictive framework for developmental epigenetics. (© The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.) |
| Contributed Indexing: | Keywords: Chromatin remodeling; DNA methylation; Developmental gene regulation; Epigenesis; Myogenesis |
| Substance Nomenclature: | 0 (Chromatin) |
| Entry Date(s): | Date Created: 20260714 Date Completed: 20260715 Latest Revision: 20260714 |
| Update Code: | 20260715 |
| DOI: | 10.1093/hmg/ddag062 |
| PMID: | 42447329 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1460-2083 |
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| DOI: | 10.1093/hmg/ddag062 |