Academic Journal
The perineurium integrates leptin with its sympathetic outflow to protect against obesity.
| Τίτλος: | The perineurium integrates leptin with its sympathetic outflow to protect against obesity. |
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| Συγγραφείς: | Sarker G; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Haberman E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Chandran A; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Monfeuga T; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Maroteau C; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Lundh S; Department of Pathology and Imaging, Global Drug Discovery, Novo Nordisk, Måløv, Denmark., Oliveira DS; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Raimondi A; Experimental Imaging Centre, IRCCS San Raffaele Scientific Institute, Milan, Italy., Ziegler K; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany., Gomes T; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal., Cordeiro TN; Instituto de Tecnologia Química e Biológica António Xavier, ITQB NOVA, Lisbon, Portugal., Parekh K; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Schmid E; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Fernández-Sanmartín P; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain., Griebel A; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany., Martinez-Sanchez N; Oxford Centre for Diabetes, Endocrinology and Metabolism, Oxford, UK., Arús BA; Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Dresden, Germany.; Medizinische Fakultät and University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.; Department of Functional Imaging in Surgical Oncology, National Center for Tumor Diseases (NCT/UCC), Dresden, Germany.; German Cancer Research Center (DKFZ), Heidelberg, Germany., Cheung SW; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Zhu Y; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Shaked M; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Knowles SCL; Department of Biology, University of Oxford, Oxford, UK., Engelhardt SH; Institute of Pharmacology and Toxicology, Technical University Munich (TUM), Munich, Germany., Iannacone M; Vita-Salute San Raffaele University, Milan, Italy.; Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy., Scherer PE; Touchstone Diabetes Center, The University of Texas Southwestern Medical Center, Dallas, TX, USA., López M; Neurobesity Group, Department of Physiology, Center for Research in Molecular Medicine and Chronic Diseases (CiMUS), Universidade de Santiago de Compostela, Santiago, Spain., Toledo EM; Research and Development, Novo Nordisk Research Centre Oxford, Oxford, UK., Domingos AI; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. ana.domingos@dpag.ox.ac.uk. |
| Πηγή: | Nature metabolism [Nat Metab] 2026 Jul; Vol. 8 (7), pp. 1563-1582. Date of Electronic Publication: 2026 Jul 13. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Berlin : Springer Nature, [2019]- |
| Ιατρικοί όροι (MeSH): | Leptin*/metabolism , Obesity*/metabolism , Obesity*/prevention & control , Obesity*/genetics , Peripheral Nerves*/metabolism , Sympathetic Nervous System*, Receptors, Leptin/metabolism ; Receptors, Leptin/genetics ; Receptors, Adrenergic, beta-2/genetics ; Receptors, Adrenergic, beta-2/metabolism ; Ganglia, Sympathetic/metabolism ; Animals ; Male ; Mice ; Energy Metabolism ; Humans ; Mice, Knockout ; Thermogenesis |
| Περίληψη: | The regulatory mechanism of leptin's afferent action in the brain is contingent upon the efferent sympathetic innervation of white and brown adipose tissues. Nonetheless, the peripheral regulation governing the afferent-efferent balance remains ambiguous. Here we show the enriched expression of both leptin receptor (Lepr) and β (© 2026. The Author(s).) |
| Competing Interests: | Competing interests: A.C., T.M., C.M., S.L. and E.M.T. work for Novo Nordisk. E.M.T., T.M. and S.L. are minor stock owners as part of an employee-offering programme. G.S. received project funding from a Novo Nordisk Postdoctoral fellowship. M.L. serves as scientific director of Gazella Biotech ( https://gazellabiotech.com/ ). The other authors declare no competing interests. |
| Σχόλια: | Erratum in: Nat Metab. 2026 Sep;8(9):2038. doi: 10.1038/s42255-026-01605-w.. (PMID: 42581328) |
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| Grant Information: | United Kingdom WT_ Wellcome Trust |
| Substance Nomenclature: | 0 (Leptin) 0 (Receptors, Leptin) 0 (Receptors, Adrenergic, beta-2) 0 (ADRB2 protein, mouse) 0 (leptin receptor, mouse) |
| Entry Date(s): | Date Created: 20260713 Date Completed: 20260724 Latest Revision: 20260923 |
| Update Code: | 20260923 |
| PubMed Central ID: | PMC13400315 |
| DOI: | 10.1038/s42255-026-01555-3 |
| PMID: | 42443582 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 2522-5812 |
|---|---|
| DOI: | 10.1038/s42255-026-01555-3 |