Academic Journal
Perfluorooctanoic acid and cancer incidence: an updated investigation of a cohort in the mid-Ohio Valley.
| Τίτλος: | Perfluorooctanoic acid and cancer incidence: an updated investigation of a cohort in the mid-Ohio Valley. |
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| Συγγραφείς: | Hofmann JN; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States. Electronic address: hofmannjn@mail.nih.gov., Tan Y; Rollins School of Public Health, Emory University, Atlanta, GA, United States., Barry V; Rollins School of Public Health, Emory University, Atlanta, GA, United States., Taylor A; Information Management Services, Inc., Calverton, MD, United States., Winquist A; Mercer School of Medicine, Columbus, GA, United States., Hyer M; Information Management Services, Inc., Calverton, MD, United States., Graubard BI; Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States., Steenland K; Rollins School of Public Health, Emory University, Atlanta, GA, United States., Silverman DT; Occupational and Environmental Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States. |
| Πηγή: | Environment international [Environ Int] 2026 Aug; Vol. 214, pp. 110405. Date of Electronic Publication: 2026 Jul 10. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: Original Publication: Oxford; Elmsford, N. Y., Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Caprylates*/blood , Fluorocarbons*/blood , Neoplasms*/epidemiology , Neoplasms*/chemically induced , Environmental Exposure*/statistics & numerical data , Environmental Pollutants*/blood, Ohio/epidemiology ; Testicular Neoplasms/epidemiology ; Humans ; Incidence ; Male ; Female ; Cohort Studies ; Middle Aged ; Adult ; Aged |
| Περίληψη: | Background: Perfluorooctanoic acid (PFOA) has been classified as a human carcinogen based partly on limited epidemiologic evidence of increased kidney and testicular cancer risk. We conducted an updated analysis of cancer incidence in a high PFOA-exposed cohort of community members and workers in the mid-Ohio Valley with follow-up extended by approximately 10 years on average and linkage to the Virtual Pooled Registry-Cancer Linkage System to better characterize risk of malignancies of a priori interest and to explore risk of other cancers. Methods: Based on estimates of annual serum PFOA concentrations during 1952-2020, we evaluated associations between cumulative PFOA exposure and site-specific cancer incidence through 2020 among 32,050 participants (28,398 community members and 3,652 workers). Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models adjusted for potential confounding factors. Results: In the overall study population, we observed positive associations with kidney and testicular cancers. Associations with kidney cancer for high PFOA exposure were most pronounced among younger community members (≤60 years: HR Conclusions: Our findings in this high PFOA-exposed cohort provide additional epidemiologic evidence of increased kidney and testicular cancer risk, as well as new evidence of associations with thyroid and pancreatic cancers. These findings have important implications regarding our understanding of the carcinogenic potential of PFOA and the cancer burden related to this ubiquitous environmental contaminant. (Published by Elsevier Ltd.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Substance Nomenclature: | 0 (Caprylates) 0 (Fluorocarbons) 947VD76D3L (perfluorooctanoic acid) 0 (Environmental Pollutants) |
| Entry Date(s): | Date Created: 20260713 Date Completed: 20260729 Latest Revision: 20260729 |
| Update Code: | 20260730 |
| DOI: | 10.1016/j.envint.2026.110405 |
| PMID: | 42442238 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-6750 |
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| DOI: | 10.1016/j.envint.2026.110405 |