Academic Journal
Voice disturbances in Parkinson's disease and essential tremor: A cross-sectional acoustic comparison.
| Τίτλος: | Voice disturbances in Parkinson's disease and essential tremor: A cross-sectional acoustic comparison. |
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| Συγγραφείς: | Gasca-Salas C; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain; University CEU-San Pablo, Madrid, Spain. Electronic address: cgascasalas@outlook.com., Montero Pizarro OG; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain; PhD Program in Health Sciences, University of Alcalá de Henares. Alcalá de Henares, Madrid, Spain., Šimek M; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, 160 00, Czech Republic., Jiménez-Castellanos T; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Trompeta C; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain; PhD Program in Health Sciences, University of Alcalá de Henares. Alcalá de Henares, Madrid, Spain., Del Toro-Pérez C; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Máñez J; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Ruiz-Yanzi A; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Matarazzo M; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Martínez-Fernández R; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Sanabria J; ENT Department Fundación Jiménez Díaz, Madrid, Spain., Obika S; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Natera-Villalba E; HM CINAC (Centro Integral de Neurociencias Abarca Campal), Hospital Universitario HM Puerta Del Sur, HM Hospitales, Madrid, Spain; Instituto de Investigación Sanitaria HM Hospitales, Madrid, Spain., Rusz J; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Technická 2, 160 00, Czech Republic; Department of Neurology and Centre of Clinical Neuroscience, First Faculty of Medicine, Charles University, Prague, Czech Republic. |
| Πηγή: | Parkinsonism & related disorders [Parkinsonism Relat Disord] 2026 Sep; Vol. 150, pp. 108423. Date of Electronic Publication: 2026 Jul 09. |
| Τύπος έκδοσης: | Journal Article; Observational Study; Comparative Study |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: England NLM ID: 9513583 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5126 (Electronic) Linking ISSN: 13538020 NLM ISO Abbreviation: Parkinsonism Relat Disord Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Kidlington, Oxford, U.K. ; Tarrytown, NY : Elsevier Science, c1995- |
| Ιατρικοί όροι (MeSH): | Parkinson Disease*/complications , Parkinson Disease*/physiopathology , Essential Tremor*/complications , Essential Tremor*/physiopathology , Voice Disorders*/etiology , Voice Disorders*/physiopathology , Voice Disorders*/diagnosis , Speech Acoustics*, Humans ; Female ; Cross-Sectional Studies ; Male ; Aged ; Middle Aged |
| Περίληψη: | Background: Dysphonia is frequent in Parkinson's disease (PD) and essential tremor (ET), the most prevalent movement disorder entities. Direct comparisons of acoustic speech features between them are scarce. This study aimed to establish an objective basis for distinguishing these forms of pathological speech. Methods: We performed an observational cross-sectional study with 33 PD patients, 32 ET patients, and 38 healthy controls (HC). We assessed subjective voice impairment using the Voice Handicap Index (VHI) and objective voice parameters with a sustained phonation vocal task. Clinical severity was evaluated using established scales. Results: Compared to HC, ET patients exhibited higher jitter, shimmer and modulation depth of frequency tremor. And lower harmonics-to-noise ratio. PD patients showed higher shimmer and lower first spectral moment of mean long-term average spectra, cepstral peak prominence, and harmonics-to-noise ratio. In the comparison between patients, ET subjects had higher modulation depth of frequency tremor than PD. PD and ET patients scored higher than HC in total VHI and its subscores. Functional subscore was higher in PD than in ET. Significant correlations were found between acoustic parameters and VHI, especially in the ET group, with the strongest correlation for LTAS first spectral moment with VHI-emotional (r = 0.56,P = 0.002). Conclusion: While ET and PD patients overlap in acoustic voice abnormalities that affect voice quality, a higher extent of frequency tremor was distinctive for ET. Both cohorts reported a higher subjective impact of voice tremor in comparison with HC. Acoustic parameters seemed to align more with patient reported outcomes in ET than in PD. (Copyright © 2026 Elsevier Ltd. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jan Rusz reports financial support was provided by Ministry of Health of the Czech Republic. Co-author reports speaker honoraria from Insightec, Palex, Medtronic, Orion, Esteve, Zambon and Bial outside the submitted work and a grant/research funding from Instituto de Salud Carlos III, Madrid, Spain for health research projects (PI21 Proyectos de investigación en salud, AES 2021). - R.F.M. Co-author received contracts or grants from the International Parkinson and Movement Disorders Society (MDS Podcast), and Michael J Fox Foundation (Grant ID: 16,451); payment or honoraria for lectures, presentations, speakers bureaus, or educational events from Zambon, Bial, Insightec, International Parkinson and Movement Disorders Society, Sociedad Española de Neurología. Stock: Biogen. - M.M. Co-author has received financial support from Zambon, Bial, Esteve, and Insightec to attend scientific meetings, speaker honoraria from Palex, and grants from Sociedad Española de Neurología and Asociación Madrileña de Neurología. - E.N.V. Co-author received the following grants: Osaka University Support for Pioneering Research Initiated by the Next Generation (JST SPRING, Grant Number JPMJSP2138), Awarded 2023-2024. Osaka University Scholarship for Overseas Research Activities, Awarded 2023. JSPS Overseas Challenge Program for Young Researchers, Awarded 2023. Research Fellow of Japan Society for the Promotion of Science, Awarded 2024. - O.S. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: Acoustic analysis; Essential tremor; Parkinson's disease; Voice |
| Entry Date(s): | Date Created: 20260713 Date Completed: 20260904 Latest Revision: 20260914 |
| Update Code: | 20260915 |
| DOI: | 10.1016/j.parkreldis.2026.108423 |
| PMID: | 42442096 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-5126 |
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| DOI: | 10.1016/j.parkreldis.2026.108423 |