Academic Journal
Immune-Endocrine crosstalk in hypertensive overweight men: Dysregulation of IL-17 and IL-40-mediated inflammatory pathways.
| Τίτλος: | Immune-Endocrine crosstalk in hypertensive overweight men: Dysregulation of IL-17 and IL-40-mediated inflammatory pathways. |
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| Συγγραφείς: | Ibrahim RK; Department of Biology, College of Education, Aliraqia University, Baghdad, Iraq., Mahmmod HM; Department of Biology, College of Education, Aliraqia University, Baghdad, Iraq., Majeed ME; College of Health and Medical Techniques/Al-Dour, Northern Technical University, Iraq. |
| Πηγή: | The Egyptian journal of immunology [Egypt J Immunol] 2026 Jul; Vol. 33 (3), pp. 1-8. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Modern Commercial Press Country of Publication: Egypt NLM ID: 9816016 Publication Model: Print Cited Medium: Print ISSN: 1110-4902 (Print) Linking ISSN: 11104902 NLM ISO Abbreviation: Egypt J Immunol Subsets: MEDLINE |
| Imprint Name(s): | Original Publication: Cairo : Modern Commercial Press |
| Ιατρικοί όροι (MeSH): | Hypertension*/immunology , Hypertension*/blood , Interleukin-17*/blood , Interleukin-17*/immunology , Overweight*/immunology , Overweight*/blood , Inflammation*/immunology, Tumor Necrosis Factor-alpha/blood ; Biomarkers/blood ; Humans ; Male ; Adult ; Middle Aged ; Case-Control Studies ; Blood Pressure |
| Περίληψη: | Hypertension belongs to the category of serious health concerns among overweight people that are frequently attributed to chronic low-grade inflammation. The present study investigated the significance of the selected pro-inflammatory cytokines interleukin-17 (IL-17), interleukin-40 (IL-40), and tumor necrosis factor-alpha (TNF- α) as the markers of inflammation in non-smoking overweight men with hypertension. This case control study included 70 adult men (40 hypertensive and 30 age matched controls). Anthropometric parameters, arterial blood pressure, lipid profile, liver enzymes, renal function markers, aldosterone, cortisone, and serum cytokines were investigated. The concentrations of cytokines were determined through the enzyme-linked immunosorbent assay procedures. Body weight, body mass index, systolic and diastolic blood pressure, among hypertensive participants, were significantly higher in the cases than the controls (p≤0.01). Hypertensive subjects had significantly high serum concentrations of TNF-α, IL-17 and IL-40, which are indicators of a strong pro-inflammatory condition. Also, hypertensive patients were characterized by dyslipidemia and raised liver enzyme activity, raised aldosterone and cortisone levels, and slight but significant rises in serum creatinine. The results indicated that hypertension among overweight non-smoking men is interrelated with immune response, metabolic dysregulation as well as endocrine dysregulation. It is interesting to note that IL-40 was also a candidate novel inflammatory biomarker in addition to the previously known cytokines, TNF- α and IL- 17. The study findings revealed that the inflammatory and immune-endocrine pathways could be a new chance in the early management and detection of obesity-related hypertension. (Copyright© by the Egyptian Association of Immunologists.) |
| Substance Nomenclature: | 0 (Interleukin-17) 0 (Tumor Necrosis Factor-alpha) 0 (Biomarkers) |
| Entry Date(s): | Date Created: 20260713 Date Completed: 20260713 Latest Revision: 20260713 |
| Update Code: | 20260714 |
| DOI: | 10.55133/eji.330301 |
| PMID: | 42440348 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1110-4902 |
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| DOI: | 10.55133/eji.330301 |