Academic Journal
rK39-Negative Visceral Leishmaniasis with Renal Complications from Eastern Uttar Pradesh, India: A Case-Based Clinico-Entomological Investigation Suggesting Possible Local Transmission.
| Τίτλος: | rK39-Negative Visceral Leishmaniasis with Renal Complications from Eastern Uttar Pradesh, India: A Case-Based Clinico-Entomological Investigation Suggesting Possible Local Transmission. |
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| Συγγραφείς: | Maurya SK; Molecular Arthropod Research Lab (MARL), ICMR-Regional Medical Research Centre, Gorakhpur, India., Kumar A; State Health Department, Maharajganj, India., Kumar N; Molecular Arthropod Research Lab (MARL), ICMR-Regional Medical Research Centre, Gorakhpur, India., Dwivedi GR; Microbiology Lab, VRDL, ICMR-Regional Medical Research Centre, Gorakhpur, India., Mishra N; Molecular Arthropod Research Lab (MARL), ICMR-Regional Medical Research Centre, Gorakhpur, India. nalini10mishra@gmail.com. |
| Πηγή: | Acta parasitologica [Acta Parasitol] 2026 Jul 13; Vol. 71 (4). Date of Electronic Publication: 2026 Jul 13. |
| Τύπος έκδοσης: | Journal Article; Case Reports |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 9301947 Publication Model: Electronic Cited Medium: Internet ISSN: 1896-1851 (Electronic) Linking ISSN: 12302821 NLM ISO Abbreviation: Acta Parasitol Subsets: MEDLINE |
| Imprint Name(s): | Publication: 2019- : Cham : Springer International Publishing Original Publication: Warszawa : Witold Stefanski Institute Of Parasitology |
| Ιατρικοί όροι (MeSH): | Leishmaniasis, Visceral*/transmission , Leishmaniasis, Visceral*/complications , Leishmaniasis, Visceral*/diagnosis , Leishmaniasis, Visceral*/parasitology , Leishmaniasis, Visceral*/drug therapy , Leishmania donovani*/isolation & purification , Phlebotomus*/parasitology, Phosphorylcholine/analogs & derivatives ; Phosphorylcholine/therapeutic use ; Antiprotozoal Agents/therapeutic use ; Insect Vectors/parasitology ; Male ; Humans ; India ; Animals ; Middle Aged |
| Περίληψη: | Purpose: The Government of India has made significant progress toward the elimination of visceral leishmaniasis (Kala-azar); however, sporadic cases continue to emerge, threatening the achievement of the elimination target. We report one confirmed case of Kala-azar from the Maharajganj district of Eastern Uttar Pradesh, an area with limited previous documentation of indigenous transmission. Methods: A 60-year-old male with no travel history (Bihar, Nepal), presenting with fever, splenomegaly, and anaemia. He tested negative by rK39, confirming by bone marrow aspirate demonstrated intracellular amastigotes of Leishmania donovani an indigenous case from Maharajganj. The patient developed acute renal impairment (serum creatinine 5.6 mg/dL). Miltefosine therapy was initiated but discontinued due to haematuria. Results: The detection of the competent vector in close proximity to the patient's residence provides supportive entomological evidence for local transmission. Due to the limited scale of sampling, vector density could not be estimated; however, the confirmed presence of Phlebotomus argentipes indicates ecological suitability for transmission. Conclusion: These cases highlight the importance of maintaining robust surveillance, early diagnosis, and rapid treatment, especially for detecting indigenous transmission in regions nearing elimination. Continued vigilance is essential to achieve and sustain the elimination of Kala-azar in India. (© 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG.) |
| Competing Interests: | Declarations. Conflict of interest: The authors declare no conflict of interest. Informed Consent: has been taken from the patient and/or their legal representative for the publication of anonymized clinical details and images was secured. The research integrity Committee of ICMR-RMRC Gorakhpur granted publication approval for the same. |
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| Contributed Indexing: | Keywords: Phlebotomus argentipes; Epidemiology; India; Kala-azar; Miltefosine; Sandfly; Visceral leishmaniasis |
| Substance Nomenclature: | 53EY29W7EC (miltefosine) 107-73-3 (Phosphorylcholine) 0 (Antiprotozoal Agents) |
| Entry Date(s): | Date Created: 20260713 Date Completed: 20260713 Latest Revision: 20260822 |
| Update Code: | 20260822 |
| DOI: | 10.1007/s11686-026-01338-6 |
| PMID: | 42440159 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1896-1851 |
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| DOI: | 10.1007/s11686-026-01338-6 |