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Correlation of Transcutaneous pCO2 and Capillary pCO2 in Newborn Patients Depending on Gestational Age: A Secondary Data Analysis.

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Τίτλος: Correlation of Transcutaneous pCO2 and Capillary pCO2 in Newborn Patients Depending on Gestational Age: A Secondary Data Analysis.
Συγγραφείς: Olivier L; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany., Lauterbach Oprea C; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Stollenwerk A; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Pfannschmidt V; Chair of Embedded Software (Computer Science 11), RWTH Aachen University, Aachen, Germany., Orlikowsky T; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany., Schoberer M; Division of Neonatology, Department of Pediatric and Adolescent Medicine, Uniklinik RWTH Aachen, Aachen, Germany.
Πηγή: Pediatric pulmonology [Pediatr Pulmonol] 2026 Jul; Vol. 61 (7), pp. e71733.
Τύπος έκδοσης: Journal Article
Γλώσσα: English
Στοιχεία περιοδικού: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8510590 Publication Model: Print Cited Medium: Internet ISSN: 1099-0496 (Electronic) Linking ISSN: 10990496 NLM ISO Abbreviation: Pediatr Pulmonol Subsets: MEDLINE
Imprint Name(s): Publication: <2005-> : Hoboken, NJ : Wiley-Liss
Original Publication: [Philadelphia, PA] : W.B. Saunders, [c1985-
Ιατρικοί όροι (MeSH): Carbon Dioxide*/blood , Blood Gas Monitoring, Transcutaneous*/methods , Gestational Age* , Capillaries*, Humans ; Infant, Newborn ; Female ; Male ; Intensive Care Units, Neonatal ; Infant, Premature ; Partial Pressure ; Infant, Extremely Premature ; Cohort Studies
Περίληψη: Introduction: Transcutaneous monitoring of CO2 partial pressure (tcpCO2) provides continuous information about the CO2 partial pressure in the blood (pCO2). However, the deviation of tcpCO2 from pCO2 is variable. Our aim was to assess whether this deviation depends on gestational age in the first postnatal week.
Methods: Single-center secondary data cohort study at a Tertiary Care NICU. 116 neonates undergoing tcpCO2 monitoring were included. A linear mixed-effects model was used to analyze the difference between tcpCO2 and capillary pCO2 (ΔpCO2) in the first postnatal week.
Results: 926 simultaneous measurements were included. The evaluation of the linear mixed-effects model revealed a significant effect of gestational age on ΔpCO2. Median [interquartile 1; interquartile 3] ΔpCO2 was significantly higher for extremely preterm infants (< 28 weeks) with 7.6 [2.4; 13.9] mmHg compared to 3.1 [-1.0; 6.4] mmHg for very preterm (28-31 + 6 weeks), 0.6 [-4.6; 4.7] mmHg for late preterm (32-36 + 6 weeks) and -0.5 [-4.8; 4.7] mmHg for term infants (≥ 37 weeks). There were no significant differences in ΔpCO2 between patients born at 23 to 25 compared to 26 and 27 completed weeks of gestation. In multivariable analysis, gestational age, early-onset bacterial infection and capillary pCO2 were independently associated with ΔpCO2, whereas birth weight was not.
Conclusions: The gestational age has a significant directed effect on the accuracy of transcutaneous CO2 monitoring in preterm neonates and can-together with other known influence factors-be used to improve the non-invasive pCO2 estimation.
(© 2026 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC.)
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Grant Information: 031L0303 BMFTR
Contributed Indexing: Keywords: carbon dioxide; neonatal intensive care unit; neonate; premature infants; transcutaneous blood gas monitoring; transcutaneous capnometry
Substance Nomenclature: 142M471B3J (Carbon Dioxide)
Entry Date(s): Date Created: 20260713 Date Completed: 20260713 Latest Revision: 20260813
Update Code: 20260814
PubMed Central ID: PMC13358317
DOI: 10.1002/ppul.71733
PMID: 42438310
Βάση Δεδομένων: MEDLINE
Περιγραφή
ISSN:1099-0496
DOI:10.1002/ppul.71733