Academic Journal
Establishing quality management system for biomonitoring laboratory network: based on element internal exposures in China national human biomonitoring.
| Τίτλος: | Establishing quality management system for biomonitoring laboratory network: based on element internal exposures in China national human biomonitoring. |
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| Συγγραφείς: | Song H; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Qiu T; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Lv Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Zhao F; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Lu Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Ji S; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Qu Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Ding L; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Song S; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Zhang M; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Sun Q; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Li Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Wang C; Chemical Analysis & Physical Testing Institute, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China., Wen S; Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, China., Zhang H; Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China., Ruan S; Chemical Analysis & Physical Testing Institute, Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong, China., Tang L; Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei, China., Zhu Y; Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China., Zhu Y; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Cao Z; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Lin S; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China., Zheng Y; School of Public Health, Qingdao University, Qingdao, Shandong, China., Qu W; Center for Water and Health, Key Laboratory of the Public Health Safety, Ministry of Education, Department of Environment Health, School of Public Health, Fudan University, Shanghai, China. Electronic address: wdqu@fudan.edu.cn., Shi X; China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China. Electronic address: shixm@chinacdc.cn. |
| Πηγή: | Environment international [Environ Int] 2026 Aug; Vol. 214, pp. 110408. Date of Electronic Publication: 2026 Jul 06. |
| Τύπος έκδοσης: | Journal Article |
| Γλώσσα: | English |
| Στοιχεία περιοδικού: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 7807270 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6750 (Electronic) Linking ISSN: 01604120 NLM ISO Abbreviation: Environ Int Subsets: MEDLINE |
| Imprint Name(s): | Publication: Original Publication: Oxford; Elmsford, N. Y., Pergamon Press. |
| Ιατρικοί όροι (MeSH): | Biological Monitoring*/methods , Biological Monitoring*/standards , Laboratories*/standards , Environmental Exposure*/analysis , Environmental Exposure*/statistics & numerical data , Environmental Monitoring*/methods , Environmental Monitoring*/standards , Environmental Pollutants*/blood , Environmental Pollutants*/urine, Metals, Heavy/blood ; Metals, Heavy/urine ; Metalloids/blood ; Metalloids/urine ; Humans ; China ; Quality Control |
| Περίληψη: | Objective: To build a multi-center laboratory network in the China National Human Biomonitoring (CNHBM) program and deliver high-quality datasets supporting national human biomonitoring exposure assessment and public health policy-making. Methods: A systematic Quality Management System (QMS) framework was established, encompassing laboratory network building, standardized policies, resource allocation, and a rigorous Quality Evaluation System (QES). Applicant laboratories underwent interlaboratory comparison investigations (ICI) using identical test samples. Certified network laboratories implemented strict standard operating procedures, analyzed reference materials and program-specific blinded Quality Control (QC) pools, and performed incurred sample reanalysis throughout the analytical process. Results: Through ICI, four laboratories were certified for heavy metals and metalloids (HMMs) analysis. Throughout the measurement of 21,701 blood and 21,704 urine samples, internal quality control (IQC) demonstrated high precision (CV% generally <15%, >80% within the reference range), and the median relative percentage difference (RPD) in sample reanalysis was below 5%. External quality control (EQC) using CNHBM-specific QC pools confirmed excellent inter-laboratory comparability, with overall coefficients of variation for key HMMs maintained below 15%. Conclusion: This study presents the first successful implementation of an integrated QMS framework for a national biomonitoring program in China. The framework effectively harmonized multi-laboratory data production, yielding a high-quality, unified national dataset for exposure assessment and public health policy-making, and provides a replicable model for large-scale environmental health surveillance initiatives. (Copyright © 2026 The Authors. Published by Elsevier Ltd.. All rights reserved.) |
| Competing Interests: | Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. |
| Contributed Indexing: | Keywords: China national human biomonitoring (CNHBM); Heavy metals and metalloids (HMMs); Interlaboratory comparison investigations (ICI); Quality evaluation system (QES); Quality management system (QMS) |
| Substance Nomenclature: | 0 (Metals, Heavy) 0 (Metalloids) 0 (Environmental Pollutants) |
| Entry Date(s): | Date Created: 20260710 Date Completed: 20260729 Latest Revision: 20260729 |
| Update Code: | 20260730 |
| DOI: | 10.1016/j.envint.2026.110408 |
| PMID: | 42431008 |
| Βάση Δεδομένων: | MEDLINE |
| ISSN: | 1873-6750 |
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| DOI: | 10.1016/j.envint.2026.110408 |